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Binding of yohimbine and imipramine to platelets in depressive illness

Published online by Cambridge University Press:  09 July 2009

L. Braddock ,
P. J. Cowen ,
J. M. Elliott ,
S. Fraser  and
K. Stump
L. Braddock
Affiliation:
University Department of Psychiatry and the MRC Unit of Clinical Pharmacology, Research Unit, Littlemore Hospital, Oxford
P. J. Cowen*
Affiliation:
University Department of Psychiatry and the MRC Unit of Clinical Pharmacology, Research Unit, Littlemore Hospital, Oxford
J. M. Elliott
Affiliation:
University Department of Psychiatry and the MRC Unit of Clinical Pharmacology, Research Unit, Littlemore Hospital, Oxford
S. Fraser
Affiliation:
University Department of Psychiatry and the MRC Unit of Clinical Pharmacology, Research Unit, Littlemore Hospital, Oxford
K. Stump
Affiliation:
University Department of Psychiatry and the MRC Unit of Clinical Pharmacology, Research Unit, Littlemore Hospital, Oxford
*
1Address for correspondence: Dr P. J. Cowen, Littlemore Hospital, Oxford OX4 4XN.
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Synopsis

Radioligand binding to intact platelets was carried out in antidepressant-free patients and the 1 mg dexamethasone suppression test (DST) was performed. There were no differences in binding characteristics between patients and controls for either [H]yohimbine or [H]imipramine. There were no differences in binding between patients classified as endogenous using the Newcastle Scale, compared with non-endogenous patients, and no difference between DST suppressors and non-suppressors. The severity of depression did not affect binding values. After 4–6 weeks antidepressant treatment [H]yohimbine binding was significantly reduced but [H]imipramine binding was unaffected.

Type
Research Article
Information
Psychological Medicine , Volume 16 , Issue 4 , November 1986 , pp. 765 - 773
Copyright
Copyright © Cambridge University Press 1986

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