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Continuation therapy with lithium and amitriptyline in unipolar depressive illness: a randomized, double-blind, controlled trial

Published online by Cambridge University Press:  09 July 2009

A. I. M. Glen ,
A. L. Johnson  and
M. Shepherd
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Synopsis

A detailed analysis of the results of a multi-centre clinical trial shows that, while the relapse rate following recovery from an operationally defined depressive illness was smaller among patients subsequently treated with either amitryptiline or lithium than with a placebo, there was no clinically significant difference between the prophylactic efficacy of the 2 antidepressants. An account is given of the relative adverse effects of the treatments, and the implications of the findings are discussed.

Type
Research Article
Information
Psychological Medicine , Volume 14 , Issue 1 , February 1984 , pp. 37 - 50
Copyright
Copyright © Cambridge University Press 1984

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