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Correlates of cerebral event-related slow potentials and psychopathology

Published online by Cambridge University Press:  09 July 2009

S. A. Bachneff  and
F. Engelsmann
S. A. Bachneff*
Affiliation:
Department of Psychiatry, McGill University, Montreal, Quebec, Canada
F. Engelsmann
Affiliation:
Department of Psychiatry, McGill University, Montreal, Quebec, Canada
*
1Address for correspondence: Dr Svetlozar A. Bachneff, 22 Sunnyside Avenue, Westmount H3Y 1C2, Quebec, Canada.
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Synopsis

The study explored associations between the cerebral event-related slow potentials (ERSP) and psychiatric symptoms and syndromes as reflected by the Present State Examination (PSE) in 36 randomly selected psychiatric in-patients. Independent raters measured the readiness potential (RP), contingent negative variation (CNV) and post-imperative negative variation (PINV) in terms of their amplitude and duration. The 360 individual PSE items were grouped into units of analysis (UA) and further collapsed into groups of units of analysis (GUA). Canonical correlations were computed between two sets of variables (psychological and electrophysiological). Kendall's rank-order correlation was used as the main statistical approach. Some psychotic signs were associated with increased PINV amplitude. Obsessive thoughts, ideas of reference and verbal hallucinations correlated with longer PINV duration. Hopelessness and suicidal thoughts (affect-laden thoughts) as well as first-rank Schneiderian symptoms (FRS) were negatively correlated with CNV amplitude. The results support the hypothesis that CNV and PINV, alone or in combination, can be used to indicate the presence or absence of identifiable psychiatric symptoms and syndromes. The implications of electrophysiological correlates of psychopathology for psychiatric nosology and for the validity of psychiatric symptoms and syndromes were discussed

Type
Research Article
Information
Psychological Medicine , Volume 13 , Issue 4 , November 1983 , pp. 763 - 770
Copyright
Copyright © Cambridge University Press 1983

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References

Abraham, P., McCallum, W. C. & Gourlay, J. (1976). The CNV and its relation to specific psychiatric syndromes. In The Responsive Brain (ed. McCallum, W. C.), pp. 144–153. John Wright: Bristol.CrossRefGoogle Scholar
Akiskal, H. S. & McKinney, W. T. (1975). Overview of recent research in depression. Archives of General Psychiatry 32, 285–305.CrossRefGoogle ScholarPubMed
Chouinard, G., Annable, L., Dubrovsky, B. & Dongier, M. (1975). Post-imperative negative variation in ambulatory schizophrenic patients. Comprehensive Psychiatry 16, 457–460.CrossRefGoogle Scholar
Chouinard, G., Annable, L. & Dongier, M. (1977). Differences in psychopathology of schizophrenic patients with normal and abnormal postimperative negative variation (PINV). Comprehensive Psychiatry 18, 83–87.CrossRefGoogle ScholarPubMed
Dongier, M. (1973). Clinical applications of the CNV. Event related slow potentials of the brain: their relations to behaviour. Electroencephalography and Clinical Neurophysiology Suppl. 33, 309–315.Google Scholar
Dongier, M., Dubrovsky, B. & Engelsmann, F. (1976). Event related slow potentials: recent data on clinical significance of CNV and PINV. Research Communications in Psychology, Psychiatry and Behaviour 1,91–104.Google Scholar
Dongier, M., Dubrovsky, B. & Englesmann, F. (1977). Event related slow potentials in psychiatry. In Psychopathology and Brain Dysfunction (ed. Shagass, C., Gershon, S. and Friedhoff, A. J.), pp. 339–352. Raven Press: New York.Google Scholar
Dubrovsky, B., Garcia-Rill, E., Tepper, E. & Vanagas, J. (1973).Some aspects of the methodology of recording slow potential changes. In Biological Diagnosis of Brain Disorders. The Future of Brain Sciences(ed.Bogoch, S.), pp. 300–309. Spectrum Publications: New York.Google Scholar
Engelsmann, F. & Dongier, M. (1977). Event related slow potentials of the brain: a prognostic tool in psychiatry.Paper presented on the 27th Annual Meeting of the Canadian Psychiatric Association,Saskatoon, Saskatchewan, Canada,09 1977.Google Scholar
Engelsmann, F., Dongier, M. & Reid, J. E. (1978). Cerebral event related slow potentials in antisocial personalities. In Human Aggression and Dangerousness (ed. Gaberge-Altmejd, D.), pp. 125–143. University of Montreal: Montreal.Google Scholar
International Classification of Diseases (ICDA-8th) (1969). Dominion Bureau of Statistics: Ottawa.Google Scholar
Knott, J. R. & Irwin, D. A. (1973). Anxiety, stress and the contingent negative variation. Archives of General Psychiatry 29, 538–541.CrossRefGoogle ScholarPubMed
Kopell, B. S. & Rosenbloom, M. J. (1976). Scalp-recorded potential correlates of psychological phenomena in men. In Advances in Psychological Assessment Vol. 3 (ed. McReynolds, P.), pp. 433–476. Science and Behaviour Books: Palo Alto, California.Google Scholar
Kornhuber, H. H. & Deecke, L. (1965). Hirnpotentialänderungen bei Wilkürbewegungen und passiven Bewegungen des Menschen: Bereitschaftspotential und reafferente Potentiale. Pflügers Archiv für die gesamte Physiologie des Menschen und der Tiere 284, 1–17.CrossRefGoogle Scholar
McCallum, W. C. & Abraham, P. (1973). The contingent negative variation in psychosis. In Event Related Slow Potentials of the Brain: Their Relations to Behaviour (ed. McCallum, W. C. and Knott, J. R.), pp. 329–335. Elsevier: Amsterdam.Google Scholar
McCallum, W. C. & Knott, J. R. (eds.) (1973). Event Related Slow Potentials of the Brain: Their Relations to Behaviour. Elsevier: Amsterdam.Google Scholar
McCallum, W. C. & Walter, W. G. (1968). The differential effects of distraction on the contingent negative variation in normal subjects and psychiatric patients. Electroencephalography and Clinical Neurophysiology 24, 593.Google ScholarPubMed
McSherry, J. W. (1973). Physiological origins. In Event Related Slow Potentials of the Brain: Their Relations to Behaviour (ed.McCallum, W. C. and Knott, J. R.), pp. 53–61. Elsevier: Amsterdam.Google Scholar
Nie, H. H., Hull, C. H., Jenkins, J. G., Steinbrenner, K. & Bent, D. H. (1975). Statistical Package for the Social Sciences (SPSS). McGraw-Hill: New York.Google Scholar
Picton, T. W. & Low, M. D. (1971). The CNV and semantic content of stimuli in the experimental paradigm: effects of feedback. Electroencephalography and Clinical Neurophysiology 31, 451–456.CrossRefGoogle ScholarPubMed
Small, J. G. & Small, I. F. (1971). Contingent negative variation (CNV) correlations with psychiatric diagnosis. Archives of General Psychiatry 25, 550–554.CrossRefGoogle ScholarPubMed
Spitzer, R. L. & Wilson, P. T. (1975). Nosology and the official psychiatric nomenclature: reliability of psychiatric diagnosis. In Comprehensive Textbook of Psychiatry (ed. Freedman, A. M., Kaplan, H. I. and Sadock, B. J.), pp. 826–845. Williams & Wilkins: Baltimore.Google Scholar
Straumanis, J. J., Shagass, C. & Overton, D. A. (1969). Problems associated with application of the contingent negative variation to psychiatric research. Journal of Nervous and Mental Disease 148,170–179.CrossRefGoogle ScholarPubMed
Tecce, J. J. (1971). Contingent negative variation and individual differences. A new approach in brain research. Archives of General Psychiatry 24, 1–16.CrossRefGoogle ScholarPubMed
Tecce, J. J. (1972). Contingent negative variation (CNV) and psychological processes in man. Psychological Bulletin 77, 73–108.CrossRefGoogle ScholarPubMed
Timsit-Berthier, M. (1973). La variation contingente négative et les maladies mentales. Thesis, Doctorate in biomedical sciences: University of Liège.Google Scholar
Timsit-Berthier, M., Delaunoy, J. & Rousseau, J. C. (1973). Slow potential changes in psychiatry. II. Motor potential. Electroencephalography and Clinical Neurophysiology 35, 363–367.CrossRefGoogle ScholarPubMed
Van Praag, H. M.(1980). Central monoamine metabolism in depressions. Comprehensive Psychiatry 21, 44–54.CrossRefGoogle ScholarPubMed
Van Praag, H. M., Korf, J., Lakke, J. P. W. F. & Schut, T. (1975). Dopamine metabolism in depressions, psychoses, and Parkinson's disease: the problem of the specificity of biological variables in behaviour disorders. Psychological Medicine, 5 138–146.CrossRefGoogle Scholar
Walter, W. G. (1965). Brain responses to semantic stimuli. Journal of Psychosomatic Research 9, 51–61.CrossRefGoogle ScholarPubMed
Walter, W. G. (1971). Physiological correlates of personality. Biological Psychiatry 3, 59–69.Google ScholarPubMed
Walter, W. G., Cooper, R., Aldridge, V. J., McCallum, W. C. & Winter, A. L. (1964). Contingent negative variation: an electrical sign of sensorimotor association and expectancy in the human brain. Nature 203, 380–384.CrossRefGoogle ScholarPubMed
Whybrow, P. C. & Mendels, M. B. (1969). Toward a biology of depression: some suggestions from neurophysiology. American Journal of Psychiatry 11, 1491–1500.CrossRefGoogle Scholar
Wing, J. K., Cooper, J. E. & Sartorius, N. (1968). Present State Examination (PSE). WHO: Geneva.Google Scholar
World Health Organization (1973). The International Pilot Study of Schizophrenia (IPSS). WHO: Geneva.Google Scholar
World Health Organization (1975). Schizophrenia: a Multinational Study. Public Health Papers No. 63, pp. 48–49. WHO: Geneva.Google Scholar