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Growth hormone response to clonidine in male patients with panic disorder untreated by antidepressants

Published online by Cambridge University Press:  09 July 2009

M. Schittecatte*
Affiliation:
Hôpital Vincent Van Gogh, Marchienne-au-Pont; Psychiatric Unit, Centre Hospitalier, Universitaire du Sart Tilman, Liège, Belgium
M. Ansseau
Affiliation:
Hôpital Vincent Van Gogh, Marchienne-au-Pont; Psychiatric Unit, Centre Hospitalier, Universitaire du Sart Tilman, Liège, Belgium
G. Charles
Affiliation:
Hôpital Vincent Van Gogh, Marchienne-au-Pont; Psychiatric Unit, Centre Hospitalier, Universitaire du Sart Tilman, Liège, Belgium
R. Machowski
Affiliation:
Hôpital Vincent Van Gogh, Marchienne-au-Pont; Psychiatric Unit, Centre Hospitalier, Universitaire du Sart Tilman, Liège, Belgium
P. papart
Affiliation:
Hôpital Vincent Van Gogh, Marchienne-au-Pont; Psychiatric Unit, Centre Hospitalier, Universitaire du Sart Tilman, Liège, Belgium
W. Pichot
Affiliation:
Hôpital Vincent Van Gogh, Marchienne-au-Pont; Psychiatric Unit, Centre Hospitalier, Universitaire du Sart Tilman, Liège, Belgium
J. Wilmotte
Affiliation:
Hôpital Vincent Van Gogh, Marchienne-au-Pont; Psychiatric Unit, Centre Hospitalier, Universitaire du Sart Tilman, Liège, Belgium
*
1 Address for correspondence: Dr M. Schittecatte, Hôpital Vincent Van Gogh, 55, Rue de l'hôpital, B–6030, Marchienne-au-Pont, Belgium.

Synopsis

We report a non-significantly higher growth hormone (GH) response to intravenous clonidine administration (150 μg) in 10 male patients with panic disorder who had never received antidepressant therapy than in 10 matched controls. These results are consistent with data suggesting a normal or increased adrenergic receptor sensitivity in panic disorder patients.

Type
Brief Communication
Copyright
Copyright © Cambridge University Press 1992

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References

REFERENCES

Ansseau, M. (1985). Critères de diagnostic pour la recherche en psychiatrie. Acta Psychiatrica Belgica 85, 253324.Google Scholar
Ansseau, M., Scheyvaerts, M., Doumont, A., Poirrier, R., Legros, J. J. & Franck, G. (1984). Concurrent use of REM latency, dexamethasone suppression, clonidine and apomorphine tests as biological markers of endogenous depression: a pilot study. Psychiatry Research 12, 261272.CrossRefGoogle ScholarPubMed
Ansseau, M., von Frenkell, R., Cerfontaine, J.-L., Papart, P., Timsit-Berthier, M., Geenen, V. & Legros, J. J. (1988). Blunted response of growth hormone to clonidine and apomorphine in endogenous depression. British Journal of Psychiatry 153, 6571.CrossRefGoogle ScholarPubMed
Cameron, O. G., Smith, C. B., Hollingsworth, P. J., Nesse, R. M. & Curtis, G. C. (1984). Platelet alpha-2 adrenergic receptor binding and plasma catecholamines. Archives of General Psychiatry 41, 11441148.CrossRefGoogle ScholarPubMed
Charles, G. & Ansseau, M. (1987). Guide pour le diagnostic des troubles affectifs et de la schizophrénie. Acta Psychiatrica Belgica 87, 361516.Google Scholar
Charney, D. S. & Heninger, G. R. (1986). Abnormal regulation of noradrenergic function in panic disorders. Archives of General Psychiatry 43, 10421054.CrossRefGoogle ScholarPubMed
Corn, T., Thompson, C. & Checkley, S. A. (1984). Effects of desipramine treatment upon central adrenoceptor function in normal subjects. British Journal of Psychiatry 145, 139145.CrossRefGoogle ScholarPubMed
Eriksson, E. (1989). Neuroendocrine markers and CSF neurotransmitters and transmitter metabolites in patients with panic disorder. In Many Faces of Panic Disorder (ed. Achté, K., Tamminen, T. and Laaksonen, R.), pp. 3540. Psychiatrica Fennica Supplementum.Google Scholar
Eriksson, E., Carlsson, M., Nilsson, C. & Söderpalm, B. (1986). Does alprazolam, in contrast to diazapam, activate alpha-2 adrenoceptors involved in the regulation of rat growth hormone secretion? Life Sciences 38, 14911498.CrossRefGoogle Scholar
Eriksson, E., Modigh, K. & Jansson, J. O. (1988). Effects of sex steroids on growth hormone responses to clonidine and GHRH in reserpine pretreated rats. Journal of Neural Transmission 71, 99113.CrossRefGoogle ScholarPubMed
Ghigo, E., Bellone, E., Arvat, E., Mazza, E., Cella, S. G., Brambilla, F., Muller, E. E. & Camanni, F. (1990). Effects of alpha- and beta-adrenergic agonists and antagonists on growth hormone secretion in man. Journal of Neuroendocrinology 2, 473476.CrossRefGoogle ScholarPubMed
Hoehe, M., Valido, G. & Matussek, N. (1988). Growth hormone, noradrenaline, blood pressure and cortisol responses to clonidine in healthy male volunteers: dose response relations and reproducibility. Psychoneuroendocrinology 13, 409418.CrossRefGoogle ScholarPubMed
Hull, C. & Nie, N. H. (1981). SPSS Update 7–9. McGraw-Hill: New-York.Google Scholar
Ko, G. N., Elsworth, J. D., Roth, R. H., Rifkin, B. J., Leigh, H. & Redmond, E. Jr (1983). Panic-induced elevation of plasma MHPG levels in phobic-anxious patients: effects of clonidine and imipramine. Archives of General Psychiatry 40, 425430.CrossRefGoogle ScholarPubMed
Matussek, N., Ackenheil, M., Hippius, H., Muller, F., Schroder, H. T., Schultes, H. & Wasilewski, B. (1980). Effect of clonidine on growth hormone release in psychiatric patients and controls. Psychiatry Research 2, 2536.CrossRefGoogle ScholarPubMed
Nutt, D. J. (1986). Increased central alpha-2 adrenoceptor sensitivity in panic disorder. Psychopharmacology 90, 268269.CrossRefGoogle ScholarPubMed
Nutt, D. J. (1989). Altered central alpha-2 adrenoceptor sensitivity in panic disorder. Archives of General Psychiatry 46, 165169.CrossRefGoogle ScholarPubMed
Rapaport, M. H., Risch, S. C., Gillin, J. C., Golshan, S. & Janowski, D. S. (1989). Blunted growth hormone response to peripheral infusion of human growth hormone-releasing factor in patients with panic disorder. American Journal of Psychiatry 146, 9295.Google ScholarPubMed
Redmond, D. Jr & Huang, Y. (1979). Current concepts. II. New evidence for a locus ceruleus-norepinephrine connection with anxiety. Life Sciences 25, 21492162.CrossRefGoogle Scholar
Schittecatte, M., Charles, G., Depauw, Y., Mesters, P. & Wilmotte, J. (1988). Growth hormone response to clonidine in panic disorder patients. Psychiatry Research 23, 147151.CrossRefGoogle ScholarPubMed
Schittecatte, M., Charles, G., Machowski, R. & Wilmotte, J. (1989 a). Tricyclic wash-out and growth hormone response to clonidine. British Journal of Psychiatry 154, 858863.CrossRefGoogle ScholarPubMed
Schittecatte, M., Charles, G., Machowski, R. & Wilmotte, J. (1989 b). Growth hormone response to clonidine in untreated depressed patients. Psychiatry Research 29, 199206.CrossRefGoogle ScholarPubMed
Schittecatte, M., Charles, G., Machowski, R., Garcia-Valentin, J. & Wilmotte, J. (1991). Controversies about the clonidine test. In Biological Markers of Depression: State of the Art (ed. Ansseau, M., von Frenkell, R. and Franck, G.), pp. 5961. Excerpta Medica: International Congress Series, vol. 932.Google Scholar
Spitzer, R. L. & Endicott, J. (1978). Schedule for Affective Disorders and Shizophrenia: Lifetime Version. New York State Psychiatric Institute: New York.Google Scholar
Spitzer, R. L., Endicott, J. & Robins, E. (1977). Research Diagnostic Criteria (RDC) for a Selected Group of Functional Disorders, 3rd edn.New York State Psychiatric Institute: New York.Google Scholar
Theodorsson-Norheim, E. (1986). Kruskall Wallis test: Basic computer program to perform non-parametric one-way analysis of variance and multiple comparisons on ranks of several independent samples. Computer and Program in Biomedicine 23, 5762.CrossRefGoogle Scholar
Uhde, T. W., Vittone, B. J., Siever, L. J., Kaye, W. H. & Post, R. M. (1986). Blunted growth hormone response to clonidine in panic disorder patients. Biological Psychiatry 21, 10811085.CrossRefGoogle ScholarPubMed