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Prefrontal cortical thinning links to negative symptoms in schizophrenia via the ENIGMA consortium

Published online by Cambridge University Press:  26 May 2017

E. Walton ,
D. P. Hibar ,
T. G. M. van Erp ,
S. G. Potkin ,
R. Roiz-Santiañez ,
B. Crespo-Facorro ,
P. Suarez-Pinilla ,
N. E. M. van Haren ,
S. M. C. de Zwarte  and
R. S. Kahn
...Show all authors
E. Walton
Affiliation:
Department of Psychology, Georgia State University, Atlanta, GA 30302, USA Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, Fetscherstr. 74, 01307 Dresden, Germany Department of Psychology, Institute of Psychology, Psychiatry and Neuroscience, King's College London, London, SE5 8AF, UK
D. P. Hibar
Affiliation:
Imaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging & Informatics, University of Southern California, Marina del Rey, CA, USA
T. G. M. van Erp
Affiliation:
Department of Psychiatry and Human Behavior, University of California, Irvine, California
S. G. Potkin
Affiliation:
Department of Psychiatry and Human Behavior, University of California, Irvine, California
R. Roiz-Santiañez
Affiliation:
Department of Psychiatry, University Hospital Marqués de Valdecilla, School of Medicine, University of Cantabria–IDIVAL, Avda. Valdecilla s/n, 39008, Santander, Spain Cibersam (Centro Investigación Biomédica en Red Salud Mental), Avda. Valdecilla s/n, 39008, Santander, Spain
B. Crespo-Facorro
Affiliation:
Department of Psychiatry, University Hospital Marqués de Valdecilla, School of Medicine, University of Cantabria–IDIVAL, Avda. Valdecilla s/n, 39008, Santander, Spain Cibersam (Centro Investigación Biomédica en Red Salud Mental), Avda. Valdecilla s/n, 39008, Santander, Spain
P. Suarez-Pinilla
Affiliation:
Department of Psychiatry, University Hospital Marqués de Valdecilla, School of Medicine, University of Cantabria–IDIVAL, Avda. Valdecilla s/n, 39008, Santander, Spain Cibersam (Centro Investigación Biomédica en Red Salud Mental), Avda. Valdecilla s/n, 39008, Santander, Spain
N. E. M. van Haren
Affiliation:
Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands
S. M. C. de Zwarte
Affiliation:
Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands
R. S. Kahn
Affiliation:
Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands
W. Cahn
Affiliation:
Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands
N. T. Doan
Affiliation:
NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, University of Oslo, P.O. Box 4956 Nydalen, 0424 Oslo, Norway
K. N. Jørgensen
Affiliation:
NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, University of Oslo, P.O. Box 4956 Nydalen, 0424 Oslo, Norway Department of Psychiatric Research, Diakonhjemmet Hospital, P.O. Box 85 Vinderen, 0319 Oslo, Norway
T. P. Gurholt
Affiliation:
NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, University of Oslo, P.O. Box 4956 Nydalen, 0424 Oslo, Norway
I. Agartz
Affiliation:
NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, University of Oslo, P.O. Box 4956 Nydalen, 0424 Oslo, Norway Department of Psychiatric Research, Diakonhjemmet Hospital, P.O. Box 85 Vinderen, 0319 Oslo, Norway Department of Clinical Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden
O. A. Andreassen
Affiliation:
NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, University of Oslo, P.O. Box 4956 Nydalen, 0424 Oslo, Norway NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, P.O. Box 4956 Nydalen, 0424, Oslo, Norway
L. T. Westlye
Affiliation:
NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, P.O. Box 4956 Nydalen, 0424, Oslo, Norway
I. Melle
Affiliation:
NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, University of Oslo, P.O. Box 4956 Nydalen, 0424 Oslo, Norway NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, P.O. Box 4956 Nydalen, 0424, Oslo, Norway
A. O. Berg
Affiliation:
NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, University of Oslo, P.O. Box 4956 Nydalen, 0424 Oslo, Norway
L. Morch-Johnsen
Affiliation:
NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, University of Oslo, P.O. Box 4956 Nydalen, 0424 Oslo, Norway Department of Psychiatric Research, Diakonhjemmet Hospital, P.O. Box 85 Vinderen, 0319 Oslo, Norway
A. Færden
Affiliation:
Division of Mental Health and Addiction, Oslo University Hospital, P.O. Box 4956 Nydalen, 0424, Oslo, Norway
L. Flyckt
Affiliation:
Department of Clinical Neuroscience, Karolinska Institutet, Centre for Psychiatry Research, Norra Stationsgatan 69, 113 64 Stockholm, Sweden
H. Fatouros-Bergman
Affiliation:
Department of Clinical Neuroscience, Karolinska Institutet, Centre for Psychiatry Research, Norra Stationsgatan 69, 113 64 Stockholm, Sweden
E. G. Jönsson
Affiliation:
NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, University of Oslo, P.O. Box 4956 Nydalen, 0424 Oslo, Norway Department of Clinical Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden
R. Hashimoto
Affiliation:
Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, D3, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan Department of Psychiatry, Osaka University Graduate School of Medicine D3, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan
H. Yamamori
Affiliation:
Department of Psychiatry, Osaka University Graduate School of Medicine D3, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan
M. Fukunaga
Affiliation:
Division of Cerebral Integration, National Institute for Physiological Sciences, 38 Nishigonaka Myodaiji, Okazaki, Aichi, 444-8585, Japan
N. Jahanshad
Affiliation:
Imaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging & Informatics, University of Southern California, Marina del Rey, CA, USA
P. De Rossi
Affiliation:
NESMOS Department (Neurosciences, Mental Health and Sensory Functions), School of Medicine and Psychology, Sapienza University, Rome, Italy Department of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, 00179, Rome, Italy Department of Neurology and Psychiatry, Sapienza University of Rome, Rome, Italy
F. Piras
Affiliation:
Department of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, 00179, Rome, Italy Centro Fermi - Museo Storico della Fisica e Centro Studi e Ricerche “Enrico Fermi”, Rome, Italy
N. Banaj
Affiliation:
Department of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, 00179, Rome, Italy
G. Spalletta
Affiliation:
Department of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, 00179, Rome, Italy Beth K. and Stuart C. Yudofsky Division of Neuropsychiatry Menninger, Department of Psychiatry and Behavioral Sciences Baylor College of Medicine Houston, TX, USA
R. E. Gur
Affiliation:
Brain Behavior Laboratory, University of Pennsylvania, Philadelphia, PA 19104, USA
R. C. Gur
Affiliation:
Brain Behavior Laboratory, University of Pennsylvania, Philadelphia, PA 19104, USA
D. H. Wolf
Affiliation:
Brain Behavior Laboratory, University of Pennsylvania, Philadelphia, PA 19104, USA
T. D. Satterthwaite
Affiliation:
Brain Behavior Laboratory, University of Pennsylvania, Philadelphia, PA 19104, USA
L. M. Beard
Affiliation:
Brain Behavior Laboratory, University of Pennsylvania, Philadelphia, PA 19104, USA
I. E. Sommer
Affiliation:
Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands
S. Koops
Affiliation:
Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands
O. Gruber
Affiliation:
Department of Psychiatry and Psychotherapy, Center for Translational Research in Systems Neuroscience and Psychiatry, University Medical Center Göttingen, Von-Siebold-Str. 5, 37075 Göttingen, Germany
A. Richter
Affiliation:
Department of Psychiatry and Psychotherapy, Center for Translational Research in Systems Neuroscience and Psychiatry, University Medical Center Göttingen, Von-Siebold-Str. 5, 37075 Göttingen, Germany
B. Krämer
Affiliation:
Department of Psychiatry and Psychotherapy, Center for Translational Research in Systems Neuroscience and Psychiatry, University Medical Center Göttingen, Von-Siebold-Str. 5, 37075 Göttingen, Germany
S. Kelly
Affiliation:
Imaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging & Informatics, University of Southern California, Marina del Rey, CA, USA Trinity College, Dublin, Ireland
G. Donohoe
Affiliation:
Centre for Neuroimaging and Cognitive Genomics (NICOG), NCBES Galway Neuroscience Centre, National University of Ireland Galway, Galway, Ireland
C. McDonald
Affiliation:
Centre for Neuroimaging and Cognitive Genomics (NICOG), NCBES Galway Neuroscience Centre, National University of Ireland Galway, Galway, Ireland
D. M. Cannon
Affiliation:
Centre for Neuroimaging and Cognitive Genomics (NICOG), NCBES Galway Neuroscience Centre, National University of Ireland Galway, Galway, Ireland
A. Corvin
Affiliation:
Trinity College, Dublin, Ireland
M. Gill
Affiliation:
Trinity College, Dublin, Ireland
A. Di Giorgio
Affiliation:
Section of Psychiatry and Psychology, IRCCS Casa Sollievo della Sofferenza, S.G. Rotondo (FG), 71013, Italy
A. Bertolino
Affiliation:
Psychiatric Neuroscience Group, University of Bari ‘Aldo Moro’, Bari, 70124, Italy
S. Lawrie
Affiliation:
Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Morningside, Edinburgh, EH10 5HF, UK
T. Nickson
Affiliation:
Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Morningside, Edinburgh, EH10 5HF, UK
H. C. Whalley
Affiliation:
Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Morningside, Edinburgh, EH10 5HF, UK
E. Neilson
Affiliation:
Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Morningside, Edinburgh, EH10 5HF, UK
V. D. Calhoun
Affiliation:
The Mind Research Network, Albuquerque, NM 87106, USA Department of Electrical and Computer Engineering, University of New Mexico, Albuquerque, NM 87131, USA
P. M. Thompson
Affiliation:
Imaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging & Informatics, University of Southern California, Marina del Rey, CA, USA
J. A. Turner
Affiliation:
Department of Psychology and Neuroscience Institute, Georgia State University, Atlanta, GA 30302, USA
S. Ehrlich*
Affiliation:
Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, Fetscherstr. 74, 01307 Dresden, Germany
*
*Address for correspondence: S. Ehrlich, M.D., Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, Fetscherstr. 74, 01307 Dresden, Germany. (Email: transden.lab@uniklinikum-dresden.de)
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Abstract

Background

Our understanding of the complex relationship between schizophrenia symptomatology and etiological factors can be improved by studying brain-based correlates of schizophrenia. Research showed that impairments in value processing and executive functioning, which have been associated with prefrontal brain areas [particularly the medial orbitofrontal cortex (MOFC)], are linked to negative symptoms. Here we tested the hypothesis that MOFC thickness is associated with negative symptom severity.

Methods

This study included 1985 individuals with schizophrenia from 17 research groups around the world contributing to the ENIGMA Schizophrenia Working Group. Cortical thickness values were obtained from T1-weighted structural brain scans using FreeSurfer. A meta-analysis across sites was conducted over effect sizes from a model predicting cortical thickness by negative symptom score (harmonized Scale for the Assessment of Negative Symptoms or Positive and Negative Syndrome Scale scores).

Results

Meta-analytical results showed that left, but not right, MOFC thickness was significantly associated with negative symptom severity (βstd = −0.075; p = 0.019) after accounting for age, gender, and site. This effect remained significant (p = 0.036) in a model including overall illness severity. Covarying for duration of illness, age of onset, antipsychotic medication or handedness weakened the association of negative symptoms with left MOFC thickness. As part of a secondary analysis including 10 other prefrontal regions further associations in the left lateral orbitofrontal gyrus and pars opercularis emerged.

Conclusions

Using an unusually large cohort and a meta-analytical approach, our findings point towards a link between prefrontal thinning and negative symptom severity in schizophrenia. This finding provides further insight into the relationship between structural brain abnormalities and negative symptoms in schizophrenia.

Keywords

Cortical thicknessENIGMAFreeSurfermedial orbitofrontal cortexMRInegative symptomsPANSSSANSschizophrenia
Type
Original Articles
Information
Psychological Medicine , Volume 48 , Issue 1 , January 2018 , pp. 82 - 94
Copyright
Copyright © Cambridge University Press 2017 

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Footnotes

†

Members of Karolinska Schizophrenia Project (KaSP) are listed at the end of the article as collaborators.

References

Aderhold, DV, Weinmann, S, Hägele, C, Heinz, A (2014). Frontale Hirnvolumenminderung durch Antipsychotika? Der Nervenarzt 86, 302–323.Google Scholar
Andreasen, NC (1983). Scale for the Assessment of Negative Symptoms. University of Iowa: Iowa City.Google Scholar
Andreasen, NC, Liu, D, Ziebell, S, Vora, A, Ho, B-C (2013). Relapse duration, treatment intensity, and brain tissue loss in schizophrenia: a prospective longitudinal MRI study. The American Journal of Psychiatry 170, 609–615.CrossRefGoogle ScholarPubMed
Andreasen, NC, Olsen, S (1982). Negative v positive schizophrenia. Definition and validation. Archives of General Psychiatry 39, 789–794.Google Scholar
Andreasen, NC, Pressler, M, Nopoulos, P, Miller, D, Ho, B-C (2010). Antipsychotic dose equivalents and dose-years: a standardized method for comparing exposure to different drugs. Biological Psychiatry 67, 255–262.CrossRefGoogle ScholarPubMed
Ansell, BRE, Dwyer, DB, Wood, SJ, Bora, E, Brewer, WJ, Proffitt, TM, Velakoulis, D, McGorry, PD, Pantelis, C (2015). Divergent effects of first-generation and second-generation antipsychotics on cortical thickness in first-episode psychosis. Psychological Medicine 45, 515–527.Google Scholar
Barch, DM, Dowd, EC (2010). Goal representations and motivational drive in schizophrenia: the role of prefrontal–striatal interactions. Schizophrenia Bulletin 36, 919–934.Google Scholar
Bechara, A, Damasio, AR, Damasio, H, Anderson, SW (1994). Insensitivity to future consequences following damage to human prefrontal cortex. Cognition 50, 7–15.Google Scholar
Bechara, A, Tranel, D, Damasio, H (2000). Characterization of the decision-making deficit of patients with ventromedial prefrontal cortex lesions. Brain 123, 2189–2202.Google Scholar
Behrendt, S (2014). lm.beta: Add Standardized Regression Coefficients to lm-Objects. R package version 1.5-1. http://CRAN.R-project.org/package=lm.beta Google Scholar
Belyk, M, Brown, S (2014). Perception of affective and linguistic prosody: an ALE meta-analysis of neuroimaging studies. Social Cognitive and Affective Neuroscience 9, 1395–1403.Google Scholar
Berridge, KC, Kringelbach, ML (2015). Pleasure systems in the brain. Neuron 86, 646–664.Google Scholar
Bodnar, M, Hovington, CL, Buchy, L, Malla, AK, Joober, R, Lepage, M (2014). Cortical thinning in temporo-parietal junction (TPJ) in non-affective first-episode of psychosis patients with persistent negative symptoms. PLoS ONE 9, e101372.Google Scholar
Bracht, T, Schnell, S, Federspiel, A, Razavi, N, Horn, H, Strik, W, Wiest, R, Dierks, T, Müller, TJ, Walther, S (2013). Altered cortico-basal ganglia motor pathways reflect reduced volitional motor activity in schizophrenia. Schizophrenia Research 143, 269–276.Google Scholar
Burgdorf, J, Panksepp, J (2006). The neurobiology of positive emotions. Neuroscience & Biobehavioral Reviews 30, 173–187.CrossRefGoogle ScholarPubMed
Cahn, W, Hulshoff Pol, HE, Lems, EBTE, van Haren, NEM, Schnack, HG, van der Linden, JA, Schothorst, PF, van Engeland, H, Kahn, RS (2002). Brain volume changes in first-episode schizophrenia: a 1-year follow-up study. Archives of General Psychiatry 59, 1002–1010.Google Scholar
Cohen, AS, Minor, KS (2010). Emotional experience in patients with schizophrenia revisited: meta-analysis of laboratory studies. Schizophrenia Bulletin 36, 143–150.Google Scholar
Crespo-Facorro, B, Roiz-Santiáñez, R, Pérez-Iglesias, R, Rodriguez-Sanchez, JM, Mata, I, Tordesillas-Gutierrez, D, Sanchez, E, Tabarés-Seisdedos, R, Andreasen, N, Magnotta, V, Vázquez-Barquero, JL (2011). Global and regional cortical thinning in first-episode psychosis patients: relationships with clinical and cognitive features. Psychological Medicine 41, 1449–1460.Google Scholar
Davidson, RJ (2004). Well-being and affective style: neural substrates and biobehavioural correlates. Philosophical Transactions-Royal Society of London Series B Biological Sciences 359, 1395–1412.Google Scholar
Deserno, L, Boehme, R, Heinz, A, Schlagenhauf, F (2013). Reinforcement learning and dopamine in schizophrenia: dimensions of symptoms or specific features of a disease group? Frontiers in Psychiatry 4, 172.Google Scholar
Deserno, L, Schlagenhauf, F, Heinz, A (2016). Striatal dopamine, reward, and decision making in schizophrenia. Dialogues in Clinical Neuroscience 18, 77–89.CrossRefGoogle ScholarPubMed
Desikan, RS, Ségonne, F, Fischl, B, Quinn, BT, Dickerson, BC, Blacker, D, Buckner, RL, Dale, AM, Maguire, RP, Hyman, BT, Albert, MS, Killiany, RJ (2006). An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest. NeuroImage 31, 968–980.Google Scholar
Ducharme, S, Albaugh, MD, Hudziak, JJ, Botteron, KN, Nguyen, T-V, Truong, C, Evans, AC, Karama, S, Ball, WS, Byars, AW, Schapiro, M, Bommer, W, Carr, A, German, A, Dunn, S, Rivkin, MJ, Waber, D, Mulkern, R, Vajapeyam, S, Chiverton, A, Davis, P, Koo, J, Marmor, J, Mrakotsky, C, Robertson, R, McAnulty, G, Brandt, ME, Fletcher, JM, Kramer, LA, Yang, G, McCormack, C, Hebert, KM, Volero, H, Botteron, K, McKinstry, RC, Warren, W, Nishino, T, Almli, CR, Todd, R, Constantino, J, McCracken, JT, Levitt, J, Alger, J, O'Neil, J, Toga, A, Asarnow, R, Fadale, D, Heinichen, L, Ireland, C, Wang, D-J, Moss, E, Zimmerman, RA, Bintliff, B, Bradford, R, Newman, J, Evans, AC, Arnaoutelis, R, Pike, GB, Collins, DL, Leonard, G, Paus, T, Zijdenbos, A, Das, S, Fonov, V, Fu, L, Harlap, J, Leppert, I, Milovan, D, Vins, D, Zeffiro, T, Meter, JV, Lange, N, Froimowitz, MP, Botteron, K, Almli, CR, Rainey, C, Henderson, S, Nishino, T, Warren, W, Edwards, JL, Dubois, D, Smith, K, Singer, T, Wilber, AA, Pierpaoli, C, Basser, PJ, Chang, L-C, Koay, CG, Walker, L, Freund, L, Rumsey, J, Baskir, L, Stanford, L, Sirocco, K, Gwinn-Hardy, K, Spinella, G, McCracken, JT, Alger, JR, Levitt, J, O'Neill, J (2014). Anxious/depressed symptoms are linked to right ventromedial prefrontal cortical thickness maturation in healthy children and young adults. Cerebral Cortex 24, 2941–2950.CrossRefGoogle ScholarPubMed
Ehrlich, S, Brauns, S, Yendiki, A, Ho, B-C, Calhoun, V, Schulz, SC, Gollub, RL, Sponheim, SR (2012). Associations of cortical thickness and cognition in patients with schizophrenia and healthy controls. Schizophrenia Bulletin 38, 1050–1062.Google Scholar
Fellows, LK, Farah, MJ (2005). Different underlying impairments in decision-making following ventromedial and dorsolateral frontal lobe damage in humans. Cerebral Cortex 15, 58–63.CrossRefGoogle ScholarPubMed
Fisher, T, Shamay-Tsoory, SG, Eran, A, Aharon-Peretz, J (2011). Characterization of recovery and neuropsychological consequences of orbitofrontal lesion: a case study. Neurocase 17, 285–293.CrossRefGoogle ScholarPubMed
Furuyashiki, T, Gallagher, M (2007). Neural encoding in the orbitofrontal cortex related to goal-directed behavior. Annals of the New York Academy of Sciences 1121, 193–215.Google Scholar
Geisler, D, Walton, E, Naylor, M, Roessner, V, Lim, KO, Charles Schulz, S, Gollub, RL, Calhoun, VD, Sponheim, SR, Ehrlich, S (2015). Brain structure and function correlates of cognitive subtypes in schizophrenia. Psychiatry Research 234, 74–83.Google Scholar
Gold, JM, Waltz, JA, Matveeva, TM, Kasanova, Z, Strauss, GP, Herbener, ES, Collins, AGE, Frank, MJ (2012). Negative symptoms and the failure to represent the expected reward value of actions: behavioral and computational modeling evidence. Archives of General Psychiatry 69, 129–138.CrossRefGoogle ScholarPubMed
Goldman, AL (2009). Widespread reductions of cortical thickness in schizophrenia and spectrum disorders and evidence of heritability. Archives of General Psychiatry 66, 467.Google Scholar
Grabenhorst, F, Rolls, ET (2011). Value, pleasure and choice in the ventral prefrontal cortex. Trends in Cognitive Sciences 15, 56–67.CrossRefGoogle ScholarPubMed
Grabner, RH, Fink, A, Neubauer, AC (2007). Brain correlates of self-rated originality of ideas: evidence from event-related power and phase-locking changes in the EEG. Behavioral Neuroscience 121, 224–230.CrossRefGoogle ScholarPubMed
Haggard, P (2008). Human volition: towards a neuroscience of will. Nature Reviews Neuroscience 9, 934–946.CrossRefGoogle ScholarPubMed
Hartz, SM, Ho, B-C, Andreasen, NC, Librant, A, Rudd, D, Epping, EA, Wassink, TH (2010). G72 influences longitudinal change in frontal lobe volume in schizophrenia. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics: The Official Publication of the International Society of Psychiatric Genetics 153B, 640–647.CrossRefGoogle ScholarPubMed
Harvey, P-O, Armony, J, Malla, A, Lepage, M (2010). Functional neural substrates of self-reported physical anhedonia in non-clinical individuals and in patients with schizophrenia. Journal of Psychiatric Research 44, 707–716.Google Scholar
Harvey, P-O, Pruessner, J, Czechowska, Y, Lepage, M (2007). Individual differences in trait anhedonia: a structural and functional magnetic resonance imaging study in non-clinical subjects. Molecular Psychiatry 12, 767–775.CrossRefGoogle ScholarPubMed
Ho, B, Andreasen, N, Ziebell, S, Pierson, R, Magnotta, V (2011). Long-term antipsychotic treatment and brain volumes: a longitudinal study of first-episode schizophrenia. Archives of General Psychiatry 68, 128–137.CrossRefGoogle ScholarPubMed
Honea, R, Crow, TJ, Passingham, D, Mackay, CE (2005). Regional deficits in brain volume in schizophrenia: a meta-analysis of voxel-based morphometry studies. Am J Psychiatry 162, 2233–2245.CrossRefGoogle ScholarPubMed
Hornak, J, Bramham, J, Rolls, ET, Morris, RG, O'Doherty, J, Bullock, PR, Polkey, CE (2003). Changes in emotion after circumscribed surgical lesions of the orbitofrontal and cingulate cortices. Brain: A Journal of Neurology 126, 1691–1712.CrossRefGoogle ScholarPubMed
Jablensky, A (2006). Subtyping schizophrenia: implications for genetic research. Molecular Psychiatry 11, 815–836.Google Scholar
Jeppesen, P, Petersen, L, Thorup, A, Abel, M-B, Øhlenschlæger, J, Christensen, TØ, Krarup, G, Jørgensen, P, Nordentoft, M (2008). The association between pre-morbid adjustment, duration of untreated psychosis and outcome in first-episode psychosis. Psychological Medicine 38, 1157–1166.Google Scholar
Kalkstein, S, Hurford, I, Gur, RC (2010). Neurocognition in schizophrenia. Current Topics in Behavioral Neurosciences 4, 373–390.Google Scholar
Kawasaki, Y, Suzuki, M, Nohara, S, Hagino, H, Takahashi, T, Matsui, M, Yamashita, I, Chitnis, XA, McGuire, PK, Seto, H, Kurachi, M (2004). Structural brain differences in patients with schizophrenia and schizotypal disorder demonstrated by voxel-based morphometry. European Archives of Psychiatry and Clinical Neuroscience 254, 406–414.CrossRefGoogle ScholarPubMed
Kawasaki, Y, Suzuki, M, Takahashi, T, Nohara, S, McGuire, PK, Seto, H, Kurachi, M (2008). Anomalous cerebral asymmetry in patients with schizophrenia demonstrated by voxel-based morphometry. Biological Psychiatry 63, 793–800.Google Scholar
Kay, SR, Fiszbein, A, Opler, LA (1987). The Positive and Negative Syndrome Scale (PANSS) for schizophrenia. Schizophrenia bulletin 13, 261–276.Google Scholar
Kringelbach, ML, Rolls, ET (2004). The functional neuroanatomy of the human orbitofrontal cortex: evidence from neuroimaging and neuropsychology. Progress in Neurobiology 72, 341–372.Google Scholar
Kühn, S, Gallinat, J (2012). The neural correlates of subjective pleasantness. NeuroImage 61, 289–294.CrossRefGoogle ScholarPubMed
Lesh, TA, Tanase, C, Geib, BR, Niendam, TA, Yoon, JH, Minzenberg, MJ, Ragland, JD, Solomon, M, Carter, CS (2015). A multimodal analysis of antipsychotic effects on brain structure and function in first-episode schizophrenia. JAMA Psychiatry 72, 226–234.CrossRefGoogle ScholarPubMed
Liu, X, Hairston, J, Schrier, M, Fan, J (2011). Common and distinct networks underlying reward valence and processing stages: a meta-analysis of functional neuroimaging studies. Neuroscience & Biobehavioral Reviews 35, 1219–1236.Google Scholar
McKechanie, AG, Moorhead, TWJ, Stanfield, AC, Whalley, HC, Johnstone, EC, Lawrie, SM, Owens, DGC (2015). Negative symptoms and longitudinal grey matter tissue loss in adolescents at risk of psychosis: preliminary findings from a 6-year follow-up study. The British Journal of Psychiatry 6, 565–570.Google Scholar
Milev, P, Ho, B-C, Arndt, S, Andreasen, NC (2005). Predictive values of neurocognition and negative symptoms on functional outcome in schizophrenia: a longitudinal first-episode study with 7-year follow-up. American Journal of Psychiatry 162, 495–506.Google Scholar
Mørch-Johnsen, L, Nesvåg, R, Faerden, A, Haukvik, UK, Jørgensen, KN, Lange, EH, Andreassen, OA, Melle, I, Agartz, I (2015). Brain structure abnormalities in first-episode psychosis patients with persistent apathy. Schizophrenia Research 164, 59–64.Google Scholar
Nenadic, I, Yotter, RA, Sauer, H, Gaser, C (2015). Patterns of cortical thinning in different subgroups of schizophrenia. The British Journal of Psychiatry: the Journal of Mental Science 206, 479–483.Google Scholar
Nesvåg, R, Lawyer, G, Varnäs, K, Fjell, AM, Walhovd, KB, Frigessi, A, Jönsson, EG, Agartz, I (2008). Regional thinning of the cerebral cortex in schizophrenia: effects of diagnosis, age and antipsychotic medication. Schizophrenia Research 98, 16–28.Google Scholar
Oertel-Knöchel, V, Knöchel, C, Rotarska-Jagiela, A, Reinke, B, Prvulovic, D, Haenschel, C, Hampel, H, Linden, DEJ (2013). Association between psychotic symptoms and cortical thickness reduction across the schizophrenia spectrum. Cerebral Cortex 23, 61–70.CrossRefGoogle ScholarPubMed
Pessoa, L (2009). How do emotion and motivation direct executive control? Trends in Cognitive Sciences 13, 160–166.CrossRefGoogle ScholarPubMed
Peters, J, Büchel, C (2010). Neural representations of subjective reward value. Behavioural Brain Research 213, 135–141.Google Scholar
Plailly, J, d'Amato, T, Saoud, M, Royet, J-P (2006). Left temporo-limbic and orbital dysfunction in schizophrenia during odor familiarity and hedonicity judgments. NeuroImage 29, 302–313.Google Scholar
Price, TF, Harmon-Jones, E (2011). Approach motivational body postures lean toward left frontal brain activity. Psychophysiology 48, 718–722.Google Scholar
R Development Core Team (2008). R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing: Vienna, Austria.Google Scholar
Radua, J, Schmidt, A, Borgwardt, S, Heinz, A, Schlagenhauf, F, McGuire, P, Fusar-Poli, P (2015). Ventral striatal activation during reward processing in psychosis: a neurofunctional meta-analysis. JAMA Psychiatry 72, 1243–1251.Google Scholar
Rimol, LM, Hartberg, CB, Nesvåg, R, Fennema-Notestine, C, Hagler, DJ Jr., Pung, CJ, Jennings, RG, Haukvik, UK, Lange, E, Nakstad, PH, Melle, I, Andreassen, OA, Dale, AM, Agartz, I (2010). Cortical thickness and subcortical volumes in schizophrenia and bipolar disorder. Biological Psychiatry 68, 41–50.Google Scholar
Roesch, MR, Olson, CR (2007). Neuronal activity related to anticipated reward in frontal cortex: does it represent value or reflect motivation? Annals of the New York Academy of Sciences 1121, 431–446.CrossRefGoogle ScholarPubMed
Rosenheck, R, Leslie, D, Keefe, R, McEvoy, J, Swartz, M, Perkins, D, Stroup, S, Hsiao, JK, Lieberman, J (2006). Barriers to employment for people with schizophrenia. American Journal of Psychiatry 163, 411–417.Google Scholar
Schlagenhauf, F, Huys, QJM, Deserno, L, Rapp, MA, Beck, A, Heinze, H-J, Dolan, R, Heinz, A (2014). Striatal dysfunction during reversal learning in unmedicated schizophrenia patients. NeuroImage 89, 171–180.CrossRefGoogle ScholarPubMed
Schlagenhauf, F, Sterzer, P, Schmack, K, Ballmaier, M, Rapp, M, Wrase, J, Juckel, G, Gallinat, J, Heinz, A (2009). Reward feedback alterations in unmedicated schizophrenia patients: relevance for delusions. Biological Psychiatry 65, 1032–1039.Google Scholar
Schultz, CC, Koch, K, Wagner, G, Roebel, M, Schachtzabel, C, Gaser, C, Nenadic, I, Reichenbach, JR, Sauer, H, Schlösser, RGM (2010). Reduced cortical thickness in first episode schizophrenia. Schizophrenia Research 116, 204–209.Google Scholar
Segarra, N, Metastasio, A, Ziauddeen, H, Spencer, J, Reinders, NR, Dudas, RB, Arrondo, G, Robbins, TW, Clark, L, Fletcher, PC, Murray, GK (2016). Abnormal frontostriatal activity during unexpected reward receipt in depression and schizophrenia: relationship to anhedonia. Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology 41, 2001–2010.Google Scholar
Simon, JJ, Cordeiro, SA, Weber, M-A, Friederich, H-C, Wolf, RC, Weisbrod, M, Kaiser, S (2015). Reward system dysfunction as a neural substrate of symptom expression across the general population and patients with schizophrenia. Schizophrenia Bulletin 41, 1370–1378.Google Scholar
Strauss, GP, Frank, MJ, Waltz, JA, Kasanova, Z, Herbener, ES, Gold, JM (2011). Deficits in positive reinforcement learning and uncertainty-driven exploration are associated with distinct aspects of negative symptoms in schizophrenia. Biological Psychiatry 69, 424–431.CrossRefGoogle ScholarPubMed
Suzuki, M, Nohara, S, Hagino, H, Kurokawa, K, Yotsutsuji, T, Kawasaki, Y, Takahashi, T, Matsui, M, Watanabe, N, Seto, H, Kurachi, M (2002). Regional changes in brain gray and white matter in patients with schizophrenia demonstrated with voxel-based analysis of MRI. Schizophrenia Research 55, 41–54.Google Scholar
Szatkowska, I, Bogorodzki, P, Wolak, T, Marchewka, A, Szeszkowski, W (2008). The effect of motivation on working memory: an fMRI and SEM study. Neurobiology of Learning and Memory 90, 475–478.Google Scholar
Takeuchi, H, Taki, Y, Nouchi, R, Sekiguchi, A, Kotozaki, Y, Miyauchi, CM, Yokoyama, R, Iizuka, K, Hashizume, H, Nakagawa, S, Kunitoki, K, Sassa, Y, Kawashima, R (2014). Regional gray matter density is associated with achievement motivation: evidence from voxel-based morphometry. Brain Structure & Function 219, 71–83.Google Scholar
Tregellas, JR, Shatti, S, Tanabe, JL, Martin, LF, Gibson, L, Wylie, K, Rojas, DC (2007). Gray matter volume differences and the effects of smoking on gray matter in schizophrenia. Schizophrenia Research 97, 242–249.Google Scholar
van Erp, TGM, Hibar, DP, Rasmussen, JM, Glahn, DC, Pearlson, GD, Andreassen, OA, Agartz, I, Westlye, LT, Haukvik, UK, Dale, AM, Melle, I, Hartberg, CB, Gruber, O, Kraemer, B, Zilles, D, Donohoe, G, Kelly, S, McDonald, C, Morris, DW, Cannon, DM, Corvin, A, Machielsen, MWJ, Koenders, L, de Haan, L, Veltman, DJ, Satterthwaite, TD, Wolf, DH, Gur, RC, Gur, RE, Potkin, SG, Mathalon, DH, Mueller, BA, Preda, A, Macciardi, F, Ehrlich, S, Walton, E, Hass, J, Calhoun, VD, Bockholt, HJ, Sponheim, SR, Shoemaker, JM, van Haren, NEM, Pol, HEH, Ophoff, RA, Kahn, RS, Roiz-Santiañez, R, Crespo-Facorro, B, Wang, L, Alpert, KI, Jönsson, EG, Dimitrova, R, Bois, C, Whalley, HC, McIntosh, AM, Lawrie, SM, Hashimoto, R, Thompson, PM, Turner, JA (2015). Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium. Molecular Psychiatry 21, 547–553.CrossRefGoogle ScholarPubMed
van Erp, TGM, Preda, A, Nguyen, D, Faziola, L, Turner, J, Bustillo, J, Belger, A, Lim, KO, McEwen, S, Voyvodic, J, Mathalon, DH, Ford, J, Potkin, SG, Fbirn (2014). Converting positive and negative symptom scores between PANSS and SAPS/SANS. Schizophrenia Research 152, 289–294.Google Scholar
van Haren, NM, Schnack, HG, Cahn, W, van den Heuvel, MP, Lepage, C, Collins, L, Evans, AC, Hulshoff Pol, HE, Kahn, RS (2011). Changes in cortical thickness during the course of illness in schizophrenia. Archives of General Psychiatry 68, 871–880.Google Scholar
Venkatasubramanian, G, Jayakumar, PN, Gangadhar, BN, Keshavan, MS (2008). Automated MRI parcellation study of regional volume and thickness of prefrontal cortex (PFC) in antipsychotic-naïve schizophrenia. Acta Psychiatrica Scandinavica 117, 420–431.Google Scholar
Viechtbauer, (2010). Conducting meta-analyses in R with the metafor package. Journal of Statistical Software 36, 1–48.Google Scholar
Vita, A, De Peri, L, Deste, G, Barlati, S, Sacchetti, E (2015). The effect of antipsychotic treatment on cortical gray matter changes in schizophrenia: does the class matter? A meta-analysis and meta-regression of longitudinal magnetic resonance imaging studies. Biological Psychiatry 78, 403–412.Google Scholar
Waltz, JA, Frank, MJ, Robinson, BM, Gold, JM (2007). Selective reinforcement learning deficits in schizophrenia support predictions from computational models of striatal-cortical dysfunction. Biological Psychiatry 62, 756–764.Google Scholar
Woods, SW (2003). Chlorpromazine equivalent doses for the newer atypical antipsychotics. The Journal of Clinical Psychiatry 64, 663–667.CrossRefGoogle ScholarPubMed
Xiao, L, Xu, H, Zhang, Y, Wei, Z, He, J, Jiang, W, Li, X, Dyck, LE, Devon, RM, Deng, Y, Li, XM (2008). Quetiapine facilitates oligodendrocyte development and prevents mice from myelin breakdown and behavioral changes. Molecular Psychiatry 13, 697–708.Google Scholar
Xiao, Y, Lui, S, Deng, W, Yao, L, Zhang, W, Li, S, Wu, M, Xie, T, He, Y, Huang, X, Hu, J, Bi, F, Li, T, Gong, Q (2015). Altered cortical thickness related to clinical severity but not the untreated disease duration in schizophrenia. Schizophrenia Bulletin 41, 201–210.Google Scholar
Zald, DH, McHugo, M, Ray, KL, Glahn, DC, Eickhoff, SB, Laird, AR (2014). Meta-analytic connectivity modeling reveals differential functional connectivity of the medial and lateral orbitofrontal cortex. Cerebral Cortex 24, 232–248.Google Scholar
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