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The question of hormonal influences on intellectual development: growth hormone

Published online by Cambridge University Press:  09 July 2009

H. F. L. Meyer-Bahlburg ,
J. A. Feinman ,
M. H. MacGillivray  and
T. A. Aceto Jr
H. F. L. Meyer-Bahlburg*
Affiliation:
Children's Hospital of Buffalo and the Departments of Psychiatry and Pediatrics, State University of New York, School of Medicine
J. A. Feinman
Affiliation:
Children's Hospital of Buffalo and the Departments of Psychiatry and Pediatrics, State University of New York, School of Medicine
M. H. MacGillivray
Affiliation:
Children's Hospital of Buffalo and the Departments of Psychiatry and Pediatrics, State University of New York, School of Medicine
T. A. Aceto Jr
Affiliation:
Children's Hospital of Buffalo and the Departments of Psychiatry and Pediatrics, State University of New York, School of Medicine
*
1Address for correspondence: Dr Heino F. L. Meyer-Bahlburg, Division of Child Psychiatry, Columbia University, Psychiatric Institute, 722 West 168th Street, New York, N.Y. 10032, USA.
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Synopsis

Contrary to expectations based on findings of enhanced brain development and learning in rats after prenatal growth-hormone administration, a sample of patients with growthhormone deficiency of early onset did not show impairment of mental abilities when tested with standard intelligence tests. We conclude from our findings, as well as from other clinical reports, that growth-hormone deficiency of early onset does probably not interfere with normal human brain development.

Type
Preliminary Communication
Information
Psychological Medicine , Volume 9 , Issue 1 , February 1979 , pp. 187 - 189
Copyright
Copyright © Cambridge University Press 1979

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References

Cloutier, M. D. & Stickler, G. B. (1968). Head circumference in children with idiopathic hypopituitarism. Pediatrics 42, 209–210.CrossRefGoogle ScholarPubMed
Cohen, J. (1957). A factor-analytically based rationale for the Wechsler Adult Intelligence Scale. Journal of Consulting Psychology 21, 451–457.CrossRefGoogle ScholarPubMed
Cohen, J. (1959). The factorial structure of the WISC at ages 7–6, 10–6, 13–6. Journal of Consulting Psychology 23, 285–299.CrossRefGoogle Scholar
Croskerry, P. G. & Smith, G. K. (1975). Prolongation of gestation by growth hormone: a confounding factor in the assessment of its prenatal action. Science 189, 648–650.CrossRefGoogle ScholarPubMed
Croskerry, P. G., Smith, G. K., Shepard, B. J. & Freeman, K. B. (1973). Perinatal brain DNA in the normal and growth hormone-treated rat. Brain Research 52, 413–418.CrossRefGoogle ScholarPubMed
Dobbing, J. & Sands, J. (1973). Quantitative growth and development of human brain. Archives of Diseases of Childhood 48, 757–767.CrossRefGoogle ScholarPubMed
Drash, P. W. & Money, J. (1968). Statural and intellectual growth in congenital heart disease, in growth hormone deficiency, and in sibling controls. In Human Growth. Body Composition, Cell Growth, Energy, and Intelligence (ed. Cheek, D. B.), pp. 606–615. Lea & Febiger: Philadelphia.Google Scholar
Foster, R., Brown, A. W. & Bronstein, I. P. (1939). The mental development of a group of dwarfish children. Proceedings of the American Association of Mental Deficiency 63, 143–153.Google Scholar
Frankel, J. J. & Laron, Z. (1968). Psychological aspects of pituitary insufficiency in children and adolescents, with special reference to growth hormone. Israel Journal of Medical Sciences 4, 953–961.Google ScholarPubMed
Hollingshead, A. B. (1957). Two Factor Index of Social Position. Privately printed: New Haven.Google Scholar
Kusalic, M., Fortin, C. & Gauthier, Y. (1972). Psychodynamic aspects of dwarfism—response to growth hormone treatment. Canadian Psychiatric Association Journal 17, 29–34.CrossRefGoogle ScholarPubMed
Money, J., Drash, P. W. & Lewis, V. (1967). Dwarfism and hypopituitarism: statural retardation without mental retardation. American Journal of Mental Deficiency 72, 122–126.Google ScholarPubMed
Obuchowski, K., Zienkiewicz, H. & Graczykowska-Koczo-rowska, A. (1970). Psychological studies in pituitary dwarfism. Polish Medical Journal 9, 1229–1235.Google ScholarPubMed
Rosenbloom, A. L., Smith, D. W. & Loeb, D. G. (1966). Scholastic performance of short-statured children with hypopituitarism. Journal of Pediatrics 69, 1131–1133.CrossRefGoogle ScholarPubMed
Sara, V. R. & Lazarus, L. (1974). Prenatal action of growth hormone on brain and behaviour. Nature 250, 257–258.CrossRefGoogle ScholarPubMed
Sara, V. R., Lazarus, L., Stuart, M. C. & King, T. (1974). Fetal brain growth: selective action by growth hormone. Science 186, 446–447.CrossRefGoogle ScholarPubMed
Spencer, R. F. & Raft, D. D. (1974). Adaptation and defenses in hypopituitary dwarfs. Psychosomatics 15, 35–38.CrossRefGoogle ScholarPubMed
Wallis, H. (1960). Psychopathologische Studien bei endokrin gestörten Kindern und Jugendlichen. 3. Hypophysärer Zwergwuchs und Pubertas praecox sowie Schlussbetrachtung der mitgeteilten Beobachtungen. Zeitschrift für Kinderheilkunde 84, 89–117.CrossRefGoogle Scholar
Weber, A. (1971). Die persönliche Entwicklung hormonal behandelter hypophysarer Zwerge im Kindes- und Jugend-alter. Acta Paedopsychiatrica (Basel) Supplement 3, 1–53.Google Scholar
Wechsler, D. (1949). Wechsler Intelligence Scale for Children. Psychological Corporation: New York.Google Scholar
Wechsler, D. (1955). Wechsler Adult Intelligence Scale. Psychological Corporation: New York.Google Scholar
Wechsler, D. (1967). Wechsler Pre-school and Primary Scale of Intelligence. Psychological Corporation: New York.Google Scholar