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Tribulin in post-traumatic stress disorder

Published online by Cambridge University Press:  09 July 2009

J. Davidson ,
Vivette Glover ,
Angela Clow ,
H. Kudler ,
K. Meador  and
M. Sandler
J. Davidson
Affiliation:
Department of Psychiatry, Duke University Medical Center and Mental Hygiene Clinic, Veterans Administration Medical Center, Durham, North Carolina, USA; Department of Chemical Pathology, Queen Charlotte's Hospital, Goldhawk Road, London
Vivette Glover
Affiliation:
Department of Psychiatry, Duke University Medical Center and Mental Hygiene Clinic, Veterans Administration Medical Center, Durham, North Carolina, USA; Department of Chemical Pathology, Queen Charlotte's Hospital, Goldhawk Road, London
Angela Clow
Affiliation:
Department of Psychiatry, Duke University Medical Center and Mental Hygiene Clinic, Veterans Administration Medical Center, Durham, North Carolina, USA; Department of Chemical Pathology, Queen Charlotte's Hospital, Goldhawk Road, London
H. Kudler
Affiliation:
Department of Psychiatry, Duke University Medical Center and Mental Hygiene Clinic, Veterans Administration Medical Center, Durham, North Carolina, USA; Department of Chemical Pathology, Queen Charlotte's Hospital, Goldhawk Road, London
K. Meador
Affiliation:
Department of Psychiatry, Duke University Medical Center and Mental Hygiene Clinic, Veterans Administration Medical Center, Durham, North Carolina, USA; Department of Chemical Pathology, Queen Charlotte's Hospital, Goldhawk Road, London
M. Sandler*
Affiliation:
Department of Psychiatry, Duke University Medical Center and Mental Hygiene Clinic, Veterans Administration Medical Center, Durham, North Carolina, USA; Department of Chemical Pathology, Queen Charlotte's Hospital, Goldhawk Road, London
*
1 Address for correspondence: Professor M. Sandler, Department of Chemical Pathology, Queen Charlotte's Hospital, Goldhawk Road, London W6 0XG.
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Synopsis

Tribulin (endogenous monoamine oxidase inhibitor/benzodiazepine receptor binding inhibitor) output was measured in the urine of 18 patients with post-traumatic stress disorder (PTSD) and 13 controls. The level of the two inhibitory activities was highly significantly correlated in the group as a whole. There was no difference between output of either inhibitor in patients and controls. However, when the PTSD group was subdivided according to various psychometric ratings, a pattern of output did emerge. Levels of both inhibitory activities were higher in agitated compared with non-agitated subjects, and lower in extroverts compared with introverts. This finding supports the view that tribulin output is raised in conditions of greater arousal.

Type
Research Article
Information
Psychological Medicine , Volume 18 , Issue 4 , November 1988 , pp. 833 - 836
Copyright
Copyright © Cambridge University Press 1988

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