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The role of nerve growth factor in Alzheimer's disease

Published online by Cambridge University Press:  09 July 2009

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Abstract

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Type
Editorial
Copyright
Copyright © Cambridge University Press 1990

References

Allen, J. S., Dawbarn, D., Wilcock, G. K., Moss, T. H. & Semenenko, F. M. (1989). The distribution of beta-growth factor receptorimmunoreactive neurones in the human basal forebrain. Journal of Comparative Neurology (in the press).CrossRefGoogle Scholar
Coyle, J. T., Price, D. L. & DeLong, M. R. (1983). Alzheimer's disease: a disorder of cortical cholinergic innervation. Science 219, 11841190.CrossRefGoogle ScholarPubMed
Davis, P. (1985). Is it possible to design rational treatment for the symptoms of Alzheimer's disease? Drug Development and Research 5, 6975.CrossRefGoogle Scholar
Easter, S. S., Purves, D., Rakic, P. & Spitzer, N. C. (1985). The changing view of neuronal specificity. Science 230, 507511.CrossRefGoogle Scholar
Fine, R. E. & Rubin, J. B. (1988). Specific trophic factor receptor interactions. Key selective elements in brain development and ‘regeneration’. Journal of the American Geriatric Society 36, 457466.CrossRefGoogle ScholarPubMed
Fischer, W., Wictorin, K., Bjorklund, A., Williams, L. R., Varon, S. & Gage, F. H. (1987). Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor. Nature 329, 6568.CrossRefGoogle ScholarPubMed
Fischer, W., Gage, F. H. & Bjorklund, A. (1989). Degenerative changes in the forebrain cholinergic nuclei correlate with cognitive impairments in aged rats. European Journal of Neuroscience 1, 3445.CrossRefGoogle ScholarPubMed
Gnahn, H., Hefti, F., Heumann, M. E., Schwab, H. & Thoenen, D. (1983). NGF-mediated increase of choline acetyltransferase (ChAT) in the neonatal rat forebrain: evidence for a physiological role of NGF in the brain? Developmental Brain Research 9, 4552.CrossRefGoogle Scholar
Goedert, M., Fine, A., Hunt, S. P. & Ullrich, A. (1986). Nerve growth factor mRNA in peripheral and central rat tissues and the human central nervous system: lesion effects in the rat brain and levels in Alzheimer's disease. Molecular Brain Research 1, 8592.CrossRefGoogle Scholar
Goedert, M., Fine, A., Dawbarn, D., Wilcock, G. K. & Chao, M. V. (1989). Nerve growth factor receptor mRNA distribution in human brain: normal levels in basal forebrain in Alzheimer's disease. Molecular Brain Research 5, 17.CrossRefGoogle ScholarPubMed
Gomez-Pinilla, F., Cotman, C. W. & Nieto-Sampedro, M. (1989). NGF receptor immunoreactivity in aged rat brain. Brain Research 479, 255262.CrossRefGoogle ScholarPubMed
Greene, L. A. S., Varon, A., Piltch, A. & Shooter, E. M. (1971). Substructure of the beta-subunit of mouse 7s nerve growth factor. Neurobiology 1, 3748.Google Scholar
Hefti, F. & Weiner, W. J. (1986). Nerve growth factor and Alzheimer's disease. Annals of Neurology 20, 275281.CrossRefGoogle ScholarPubMed
Larkfors, L., Ebendal, T., Whittemore, S. R., Persson, H., Hoffer, B. & Olson, L. (1987). Decreased levels of nerve growth factor (NGF) and its messenger RNA in the aged rat brain. Molecular Brain Research 3, 5560.CrossRefGoogle Scholar
Levi-Montalcini, R. & Angeletti, P. U. (1968). Nerve Growth Factor. Physiology Review 48, 534569.CrossRefGoogle ScholarPubMed
Pearson, R. C. A., Sofroniew, M. V., Cuello, A. C., Powell, T. P. S., Eckenstein, F., Esiri, M. M. & Wilcock, G. K. (1983). Persistence of cholinergic neurons in the basal nucleus in a brain with senile dementia of the Alzheimer's type demonstrated by immunohistochemical staining for choline acetyltransferase. Brain Research 289, 375379.CrossRefGoogle Scholar
Perry, E. K., Tomlinson, B. E., Blessed, G., Bergmann, K., Gibson, P. H. & Perry, R. H. (1978). Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia. British Medical Journal ii, 14571459.CrossRefGoogle Scholar
Perry, E. K., Tomlinson, B. E., Blessed, G., Perry, R., Cross, A. J. & Crow, T. J. (1981). Neuropathological and biochemical observations on the noradrenergic system in Alzheimer's disease. Journal of Neurological Science 51, 279287.CrossRefGoogle ScholarPubMed
Schwab, M. E., Otten, U., Agid, Y. & Thoenen, H. (1979). Nerve growth factor (NGF) in the rat CNS: absence of specific retrograde axonal transport and tyrosine hydroxylase induction in locus coerulus and substantia nigra. Brain Research 168, 473483.CrossRefGoogle Scholar
Shelton, D. L. & Reichardt, L. F. (1984). Expression of the beta nerve growth factor gene correlates with the density of sympathetic innervation in effector organs.Proceedings of the National Academy of Science.USA 81, 79517955.CrossRefGoogle Scholar
Uchida, Y. & Tomonaga, M. (1989). Neurotrophic action of Alzheimer's disease brain extract is due to loss of inhibitory factors for survival and neurite formation of cerebral cortical neurons. Brain Research 481, 190193.CrossRefGoogle ScholarPubMed
Ullrich, A., Gray, A., Bergman, C & Dull, T. J. (1983). Human beta-nerve growth factor gene sequence highly homologous to that of mouse. Nature 303, 821825.CrossRefGoogle ScholarPubMed