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Tolerance to amphetamine in two species (rat and guinea pig) that metabolize it differently

Published online by Cambridge University Press:  09 July 2009

Peter S. Sever ,
John Caldwell  and
R. Tecwyn Williams
Peter S. Sever
Affiliation:
Department of Biochemistry, St Mary's Hospital Medical School, London
John Caldwell*
Affiliation:
Department of Biochemistry, St Mary's Hospital Medical School, London
R. Tecwyn Williams
Affiliation:
Department of Biochemistry, St Mary's Hospital Medical School, London
*
1Correspondence to: Dr John Caldwell, Department of Biochemistry, St Mary's Hospital Medical School, London W2 IPC
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Synopsis

It has been proposed that p-hydroxynorephedrine, a metabolite of amphetamine, is responsible for the tolerance that occurs to this drug. To test this idea, the development of tolerance to amphetamine has been examined in two species, the rat and the guinea pig, the former of which produces p-hydroxynorephedrine from amphetamine while the latter does not. In both species, tolerance develops to the anorectic and hyperthermic actions of amphetamine, and similar changes in the pattern of behavioural stimulation are seen.

Type
Research Article
Information
Psychological Medicine , Volume 6 , Issue 1 , February 1976 , pp. 35 - 42
Copyright
Copyright © Cambridge University Press 1976

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References

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