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Application of voxel phantoms to study the influence of the heterogeneous distribution of actinides in lungs on in vivo counting using animal experiments

Published online by Cambridge University Press:  28 February 2007

S. Lamart ,
N. Pierrat ,
S. Rateau ,
E. Rouit ,
L. de Carlan ,
N. Dudoignon ,
M. Bottlaender ,
A. van der Meeren  and
D. Franck
S. Lamart
Affiliation:
IRSN, Laboratoire d’Évaluation de la Dose Interne, DRPH/SDI/LEDI, B.P. 17, 92262 Fontenay-aux-Roses, France
N. Pierrat
Affiliation:
IRSN, Laboratoire d’Évaluation de la Dose Interne, DRPH/SDI/LEDI, B.P. 17, 92262 Fontenay-aux-Roses, France
S. Rateau
Affiliation:
CEA, Laboratoire de Radiotoxicologie, DSV/DRR/SRCA/LRT, B.P. 12, 91680 Bruyères-le-Châtel, France
E. Rouit
Affiliation:
CEA, Laboratoire de Radiotoxicologie, DSV/DRR/SRCA/LRT, B.P. 12, 91680 Bruyères-le-Châtel, France
L. de Carlan
Affiliation:
IRSN, Laboratoire d’Évaluation de la Dose Interne, DRPH/SDI/LEDI, B.P. 17, 92262 Fontenay-aux-Roses, France
N. Dudoignon
Affiliation:
IRSN, Laboratoire de Radiopathologie, DRPH/SRBE/LRPAT, B.P. 17, 92262 Fontenay-aux-Roses, France
M. Bottlaender
Affiliation:
CEA, Service Hospitalier Frédéric Joliot, 4, place du général Leclerc, 91400 Orsay, France
A. van der Meeren
Affiliation:
CEA, Laboratoire de Radiotoxicologie, DSV/DRR/SRCA/LRT, B.P. 12, 91680 Bruyères-le-Châtel, France
D. Franck
Affiliation:
IRSN, Laboratoire d’Évaluation de la Dose Interne, DRPH/SDI/LEDI, B.P. 17, 92262 Fontenay-aux-Roses, France
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Abstract

As part of the improvement of calibration techniques for in vivo counting, the Laboratory of Internal Dose Assessment of IRSN has developed a computer tool, “OEDIPE”, to model internal contamination in voxel phantoms, to simulate in vivo counting and to calculate internal dose. This software was used to model the real distribution of activity in the lungs of a baboon analyzed in the Laboratory of Radiotoxicology of CEA. This experiment provided the opportunity to study the influence of the heterogeneity of lung retention on the in vivo counting and to quantify its effect on the assessment of activity by comparison with a simulated homogeneous retention of the same total activity. The results show that the numerical simulation can be a relevant tool to reveal the heterogeneity of lung retention, allowing a determination of calibration factors adapted to heterogeneous contaminations that would be impossible by standard calibration with physical anthropomorphic phantoms.

Keywords

Lung countingMonte Carlo methodheterogeneous contamination modelanimal experiment
Type
Research Article
Information
Radioprotection , Volume 42 , Issue 1 , January 2007 , pp. 75 - 86
Copyright
© EDP Sciences, 2007

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