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Colony stimulating factor-1 (CSF-1) in pregnancy

Published online by Cambridge University Press:  02 March 2009

Eric Daiter  and
Jeffrey W Pollard
Eric Daiter
Affiliation:
Albert Einstein College of Medicine, New York, USA
Jeffrey W Pollard*
Affiliation:
Albert Einstein College of Medicine, New York, USA
*
Jeffrey W Pollard, Department of Developmental Biology and Cancer, Albert Einstein College of Medicine, 1300 Morris Park Avenue, New York, NY 10461, USA.
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Abstract

Uterine growth factors appear to play a role in the regulation of pregnancy. One of these, colony stimulating factor-1 (CSF-1), synthesized by the uterine epithelium under the control of female sex steroids, has been shown to have important functions both before implantation and during the formation of the placenta. In the female reproductive tract the CSF-1 receptor, the product of the c-fms proto-oncogene, is expressed in decidual cells, trophoblasts and macrophages, indicating that these cells are the primary targets for CSF-1. This article reviews the biology of CSF-1 during gestation as well as the possible involvement of CSF-1 and its receptor in the aetiology of gynaecological tumours.

Type
Articles
Information
Reproductive Medicine Review , Volume 1 , Issue 1 , March 1992 , pp. 83 - 97
Copyright
Copyright © Cambridge University Press 1992

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