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Endothelins in reproduction

Published online by Cambridge University Press:  02 March 2009

IT Cameron  and
AP Davenport
IT Cameron*
Affiliation:
University of Cambridge Clinical School, Cambridge, UK
AP Davenport
Affiliation:
University of Cambridge Clinical School, Cambridge, UK
*
IT Cameron, Department of Obstetrics and Gynaecology, The Rosie Maternity Hospital, Robinson Way, Cambridge CB2 2SW, UK.
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Extract

Endothelin-1 (ET-1) is a 21 amino acid peptide, first isolated in 1988 from porcine aortic endothelial cells in tissue culture (Figure 1). The peptide was shown to be the most potent known vasoconstrictor of porcine coronary arteries. A powerful endothelium-derived vasoconstrictor had been predicted for some time, but it was when Yanagisawa and his colleagues elucidated the structure, and provided information about the molecular biology and mode of action of the peptide that an unprecedented interest was stimulated in the endothelins.

Type
Articles
Information
Reproductive Medicine Review , Volume 1 , Issue 1 , March 1992 , pp. 99 - 113
Copyright
Copyright © Cambridge University Press 1992

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