Hostname: page-component-78c5997874-v9fdk Total loading time: 0 Render date: 2024-11-17T08:36:18.256Z Has data issue: false hasContentIssue false
  • English
  • Français

Clomipramine and Exposure for Chronic Obsessive-Compulsive Rituals: III. Two Year Follow-Up and Further Findings

Published online by Cambridge University Press:  29 January 2018

D. Mawson ,
I. M. Marks  and
L. Ramm
D. Mawson
Affiliation:
The Mauds ley Hospital, London SE5
I. M. Marks
Affiliation:
Institute of Psychiatry, London SE5
L. Ramm
Affiliation:
Institute of Psychiatry and The Maudsley Hospital
Get access Rights & Permissions [Opens in a new window]

Summary

Forty chronic ritualizers were given clomipramine or placebo from weeks 0 to 36; also all had exposure in vivo, half from weeks 4 to 10 (30 hours) and half from weeks 7 to 10 (15 hours). In the 37 patients available at week 114 there were substantial and maintained improvements in rituals, mood and social adjustment compared to week 0. Reduction of rituals was even greater in those who had 30 hours of exposure. There was no drug effect on rituals at two year follow-up. Greater initial anxiety or depression predicted the superiority of clomipramine over placebo from weeks 10 to 36 and more prescription of tricyclics in follow-up. However, two year outcome was not predicted by initial anxiety or depression, nor by sex, age, age of onset nor duration of rituals.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 140 , Issue 1 , January 1982 , pp. 11 - 18
Copyright
Copyright © The Royal College of Psychiatrists 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Black, A. (1974) The Natural History of Obsessional Neurosis. In Obsessional States (ed. Beech, H. R.). London: Methuen, p 19–54.Google Scholar
Boulougouris, J. C. (1977) Variables affecting the behaviour of obsessive-compulsive patients treated by flooding. Paper presented at EABT, Spetsae, Greece, Sept 1976. In Studies in Phobic and Obsessive-compidsive Disorders (eds. Boulougouris, J. C. and Rabavilas, A.). Oxford: Pergamon Press, pp 73—84.Google Scholar
Foa, E. B. & Goldstein, A. (1978) Continuous exposure and complete response prevention of obsessive-compulsive neurosis. Behaviour Therapy, 9, 821–9.Google Scholar
Marks, I. M., Hodgson, R. & Rachman, S. (1975) Treatment of chronic obsessive-compulsive by in vivo exposure: a two year follow-up and issues in treatment. British Journal of Psychiatry, 127, 349–64.Google Scholar
Marks, I. M., Stern, R., Mawson, D., Cobb, J. & McDonald, R. (1980) Clomipramine and exposure for obsessive compulsive rituals I and II. British Journal of Psychiatry, 136, 1—25.Google Scholar
Rachman, S., Cobb, J., Grey, S., McDonald, R., Mawson, D., Sartory, G. & Stern, R. (1979) Behavioural treatment of obsessive-compulsive disorders, with and without clomipramine. Behaviour Research and Therapy, 17, 467–8.Google Scholar
Stern, R. S., Marks, I. M., Mawson, D. & Luscombe, D. K. (1980) Clomipramine and exposure for compulsive rituals: II. Plasma Levels, side effects and outcome. British Journal of Psychiatry, 136, 161–6.Google Scholar
Sternberg, M. (1974) Physical treatments in obsessional disorders. In Obsessional States (ed. Beech, H. R.). London: Methuen, Chapter 12, p 291–306.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.