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Investigation by Linkage Analysis of the XY Pseudoautosomal Region in the Genetic Susceptibility to Schizophrenia

Published online by Cambridge University Press:  02 January 2018

Gursharan Kalsi ,
David Curtis ,
Jon Brynjolfsson ,
Robert Butler ,
Tonmoy Sharma ,
Patrice Murphy ,
Tim Read ,
Hannes Petursson  and
Hugh M. D. Gurling
Gursharan Kalsi
Affiliation:
Molecular Psychiatry Laboratory, University College London Medical School
David Curtis
Affiliation:
Institute of Psychiatry, London
Jon Brynjolfsson
Affiliation:
Department of Psychiatry, University of Iceland
Robert Butler
Affiliation:
Molecular Psychiatry Laboratory, University College London Medical School
Tonmoy Sharma
Affiliation:
Molecular Psychiatry Laboratory, University College London Medical School
Patrice Murphy
Affiliation:
Molecular Psychiatry Laboratory, University College London Medical School
Tim Read
Affiliation:
Molecular Psychiatry Laboratory, University College London Medical School
Hannes Petursson
Affiliation:
Department of Psychiatry, University of Iceland
Hugh M. D. Gurling*
Affiliation:
Molecular Psychiatry Laboratory, University College London Medical School
*
Dr Gurling, Molecular Psychiatry Laboratory, Department of Psychiatry, University College London Medical School, Riding House Street, London W1P 7PN
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Abstract

Background

A susceptibility locus for schizophrenia in the pseudoautosomal region has been proposed on the basis of a possible excess of sex chromosome aneuploidies among patients with schizophrenia and an increased sex concordance in affected sib pairs. Several studies investigating this hypothesis have produced conflicting evidence.

Method

In a series of Icelandic and British families, we used lod score and sib pair linkage analyses with markers for the MIC2 and DXYS14 loci on the pseudoautosomal XY region.

Results

Lod and sib pair linkage analysis with these markers produced strongly negative scores. Heterogeneity testing also produced negative results.

Conclusion

We conclude that the present study provides no support for the involvement of either the pseudoautosomal region or the nearby region of the sex chromosomes in the aetiology of schizophrenia.

Type
Papers
Information
The British Journal of Psychiatry , Volume 167 , Issue 3 , September 1995 , pp. 390 - 393
Copyright
Copyright © 1995 The Royal College of Psychiatrists

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References

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