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Sleep-Loss as a Possible Mediator of Diverse Causes of Mania

Published online by Cambridge University Press:  02 January 2018

Thomas A. Wehr
Thomas A. Wehr*
Affiliation:
Clinical Psychobiology Branch Intramural Research Program, National Institute of Mental Health, 9000 Rockville Pike, Bethesda, Maryland USA 20892
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Abstract

When sleep duration and mood were monitored longitudinally in a 59–year-old woman with bipolar illness, sleep loss appeared to mediate the triggering of mania by psychosocial and pharmacological precipitating factors. This interpretation was supported by observations that mania could repeatedly be induced experimentally by depriving her of sleep for one night. The patient's data illustrate how sleep-loss might be a preventable cause of mania in a variety of situations.

Type
Brief Reports
Information
The British Journal of Psychiatry , Volume 159 , Issue 4 , October 1991 , pp. 576 - 578
Copyright
Copyright © 1991 The Royal College of Psychiatrists 

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References

Bunney, W. E. Jr. & Hamburg, D. A. (1963) Methods for reliable longitudinal observation of behavior. Archives of General Psychiatry, 9, 280–294.CrossRefGoogle ScholarPubMed
Dilsaver, S. C. & Greden, J. F. (1984) Antidepressant withdrawal-induced inactivation (hypomania and mania): mechanism and theoretical significance. Brain Research, 7, 29–48.Google Scholar
Jones, B. D., Steinberg, S. & Chouinard, G. (1984) Fast-cycling bipolar disorder induced by withdrawal from long-term treatment with a tricyclic antidepressant. American Journal of Psychiatry, 141, 108–109.Google Scholar
Kusalic, M. & Ghadirian, A. M. (1990) Paradoxical mood changes during pharmacotherapy of bipolar patients. Biological Psychiatry, 27, 1183.CrossRefGoogle ScholarPubMed
Mirin, S. M., Schatzberg, A. F. & Creasey, D. E. (1981) Hypomania and mania after withdrawal of tricyclic antidepressants. American Journal of Psychiatry, 138, 87–89.Google Scholar
Turkington, D. & Gill, P. (1989) Mania induced by lorazepam withdrawal: A report of two cases. Journal of Affective Disorders, 17, 93–95.CrossRefGoogle ScholarPubMed
Wehr, T. A., Wirz-Justice, A., Goodwin, F. K., et al (1982) 48—hour sleep-wake cycles in manic-depressive illness: Naturalistic observations and sleep deprivation experiments. Archives of General Psychiatry, 39, 559–565.CrossRefGoogle ScholarPubMed
Wehr, T. A., Sack, D. A. & Rosenthal, N. E. (1987) Sleep reduction as a final common pathway in the genesis of mania. American Journal of Psychiatry, 144, 201–204.Google ScholarPubMed
Wehr, T. A. (1989) Sleep loss: A preventable cause of mania and other excited states. Journal of Clinical Psychiatry, 50 (suppl.), 8–16.Google Scholar
Wehr, T. A. (1990) Effects of wakefulness and sleep on depression and mania. In Sleep and Biological Rhythms (eds Montplaisir, J. & Godbout, R.), pp. 42–86. London: Oxford University Press.Google Scholar
Wiegand, M., Rieman, D., Schreiber, W., et al (1991) Reversal of antidepressant sleep deprivation effects by daytime naps. In Integrative Biological Psychiatry (eds Emmrich, H. M. & Wiegand, M.). Berlin: Springer Verlag (in press).Google Scholar
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