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Aetiological Heterogeneity of Schizophrenia: The Problem and the Evidence

Published online by Cambridge University Press:  02 January 2018

Per Dalén  and
Peter Hays
Per Dalén*
Affiliation:
The General Hospital, S-251 87 Helsingborg, Sweden
Peter Hays
Affiliation:
Department of Psychiatry, University of Alberta, Edmonton, Alberta T6G 2B7, Canada
*
∗Correspondence
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Extract

When Kraepelin formulated the concept of dementia praecox, he lumped together a number of diagnostic categories. One of his reasons for doing so was that he had seen many patients who ended up in the same kind of demented state, even though their initial symptoms might have been quite different. He noted that even some cases presenting with mania, or melancholia, took the same downhill course as did the more classic cases of dementia praecox. Kraepelin, aware of the striking paradigm of general paresis, stated that “a single morbid process” explained the downhill course (Kraepelin, 1983, p. 68).

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The British Journal of Psychiatry , Volume 157 , Issue 1 , July 1990 , pp. 119 - 122
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Copyright © The Royal College of Psychiatrists 

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References

Alm, T., Lindstoöm, L. H., Öst, L.-G., et al (1984) Electrodermal non-responding in schizophrenia: relationships to attentional, clinical, biochemical, computed tomographical and genetic factors. International Journal of Psychophysiology, 1, 195–208.CrossRefGoogle ScholarPubMed
Bartels, M., Mann, K. & Friedrich, W. (1965) Tardive dyskinesia: marked predominance of nongenetic schizophrenia. Biological Psychiatry, 20, 101–103.CrossRefGoogle Scholar
Bleuler, E. (1950) Dementia Praecox or the Group of Schizophrenias. New York: IUP.Google Scholar
Dalén, P. (1965) Family history, the electroencephalogram and perinatal factors in manic conditions. Acta Psychiatrica Scandinavica, 41, 527–563.CrossRefGoogle ScholarPubMed
Dalén, P. (1967) Psychiatry: empirical or rational? Lancet, ii, 217.CrossRefGoogle Scholar
Dalén, P. (1969) Causal explanations in psychiatry: a critique of some current concepts. British Journal of Psychiatry, 115, 129–137.CrossRefGoogle ScholarPubMed
Dalén, P. (1972) One, two, or many? In Genetic Factors in “Schizophrenia” (ed. A. R. Kaplan). Springfield, Ill.: Thomas.Google Scholar
Farmer, A., McGuffin, P. & Spitznagel, E. L. (1983) Heterogeneity in schizophrenia: a cluster analytic approach. Psychiatry Research, 8, 1–12.CrossRefGoogle ScholarPubMed
Farmer, A., McGuffin, P. & Gottesman, I. I. (1984) Searching for the split in schizophrenia: a twin study perspective. Psychiatry Research, 13, 109–118.CrossRefGoogle ScholarPubMed
Farmer, A., Jackson, R., McGuffin, P., et al (1987) Cerebral ventricular enlargement in chronic schizophrenia: consistencies and contradictions. British Journal of Psychiatry, 150, 324–330.CrossRefGoogle ScholarPubMed
Hays, P. (1977) Elecuoencephalographic variants and genetic predisposition to schizophrenia. Journal of Neurology, Neurosurgery, and Psychiatry, 40, 753–755.CrossRefGoogle ScholarPubMed
Hays, P. (1984) The nosological status of schizophrenia. Lancet, i, 1342–1345.CrossRefGoogle Scholar
Janzarik, W. (1987) The concept of schizophrenia: history and problems. In Search for the Causes of Schizophrenia (eds H. Häfner, W. F. Gattaz & W. Janzarik). Berlin: Springer.Google Scholar
Kaiya, H., Uematsu, M., Ofuji, M., et al (1989) Computerised tomography in schizophrenia. Familial versus non-familial forms of illness. British Journal of Psychiatry, 155, 444–450.CrossRefGoogle ScholarPubMed
Kendler, K. S. & Hays, P. (1982) Familial and sporadic schizophrenia: a symptomatic, prognostic, and EEG comparison. American Journal of Psychiatry, 139, 1557–1562.Google ScholarPubMed
Kinney, D. K. & Jacobsen, B. (1978) Environmental factors in schizophrenia: new adoption study evidence. In The Nature of Schizophrenia: New Approaches to Research and Treatment (eds L. C. Wynne, R. L. Cromwell & S. Mathysse), pp. 38–51. New York: Wiley.Google Scholar
Kraepelin, E. (1983) Lebenserinnerungen. Berlin: Springer.CrossRefGoogle Scholar
Lander, E. S. (1988) Splitting schizophrenia. Nature, 336, 95–96.CrossRefGoogle ScholarPubMed
Lewis, S. W., Reveley, A. M., Reveley, A. M., et al (1987) The familial/sporadic distinction as a strategy in schizophrenia research. British Journal of Psychiatry, 151, 306–313.CrossRefGoogle ScholarPubMed
Medawar, P. B. (1967) The Art of the Soluble. London: Methuen.Google Scholar
Murray, R. M., Lewis, S. W. & Reveley, A. M. (1985) Towards an aetiological classification of schizophrenia. Lancet, i, 1023–1026.CrossRefGoogle Scholar
Penrose, L. S. (1971) Psychiatric genetics. Psychological Medicine, 1, 265–266.CrossRefGoogle ScholarPubMed
Popper, K. R. (1963) Conjectures and Refutations. The Growth of Scientific Knowledge. London: Routledge.Google Scholar
Rosanoff, A. J. (1935) Some clinical manifestations of traumatic decerebration. Psychiatric Quarterly, 9, 116–128.CrossRefGoogle Scholar
Rosanoff, A. J. (1936) Some problems in obstetrics discussed from a neuropsychiatric standpoint. Journal of Nervous and Mental Disease, 83, 135–142.CrossRefGoogle Scholar
Rosanoff, A. J., Handy, L. M., Plesset, I. R., et al (1934) The etiology of so-called schizophrenic psychoses with special reference to their occurrence in twins. American Journal of Psychiatry, 91, 247–286.CrossRefGoogle Scholar
Rosanoff, A. J., Handy, L. M., Plesset, I. R., et al (1935) The etiology of manic-depressive syndromes with special reference to their occurrence in twins. American Journal of Psychiatry, 91, 725–762.CrossRefGoogle Scholar
Scharfetter, C. (1981) Subdividing the functional psychoses: a family hereditary approach. Psychological Medicine, 11, 637–640.CrossRefGoogle ScholarPubMed
Schulz, B. (1933) Zur Erbpathologie der Schizophrenic Zeitschrift für die gesamte Neurologic und Psychiatric 143, 175–293.CrossRefGoogle Scholar
Schulz, B. (1934) Versuch einer genealogisch-statistischen Überprüfung eines Schizophreniematerials auf biologische Einheitlichkeit. Zeitschrift für die gesamte Neurologic und Psychiatric 151, 145–170.CrossRefGoogle Scholar
Schulz, B. (1936) Methodik der medizinischen Erbforschung unter besonderer Berücksichtigung der Psychiatric Leipzig: Thieme.Google Scholar
Schwarzkopf, S. B., Nasrallah, H. A., Olson, S. C., et al (1989) Perinatal complications and genetic loading in schizophrenia: preliminary findings. Psychiatry Research, 27, 233–239.CrossRefGoogle ScholarPubMed
Sedvall, G. C. & Wode-Helgodt, B. (1980) Aberrant monoamine metabolite levels in CSF and family history of schizophrenia. Archives of General Psychiatry, 37, 1113–1116.CrossRefGoogle ScholarPubMed
Shensky, T. & Shur, E. (1982) Season of birth of schizophrenics: cyclic trends and their analysis. British Journal of Psychiatry, 141, 316–317.CrossRefGoogle ScholarPubMed
Shur, E. (1982) Season of birth in high and low genetic risk schizophrenics. British Journal of Psychiatry, 140, 410–415.CrossRefGoogle ScholarPubMed
Silverman, J. M., Mohs, R. C., Davidson, M., et al (1987) Familial schizophrenia and treatment response. American Journal of Psychiatry, 144, 1271–1276.Google ScholarPubMed
Wegner, J. T., Catalano, F., Gibralter, J., et al (1985) Schizophrenics with tardive dyskinesia. Neuropsychological deficit and family psychopathology. Archives of General Psychiatry, 42, 860–865.CrossRefGoogle ScholarPubMed
Winokur, G. (1975) Unity and diversity in schizophrenia. British Medical Journal, i, 683–684.CrossRefGoogle Scholar
Zipursky, R. B. & Schulz, S. C. (1987) Seasonality of birth and CT findings in schizophrenia. Biological Psychiatry, 22, 1288–1292.CrossRefGoogle ScholarPubMed
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