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An EEG Measure of the Effect of Mood Change on the Thiopentone Tolerance of Depressed Patients

Published online by Cambridge University Press:  29 January 2018

George W. Fenton ,
Denis Hill  and
Leila Scotton
George W. Fenton
Affiliation:
Academic Department of Psychiatry, Middlesex Hospital Medical School, London, W.1
Denis Hill
Affiliation:
Academic Department of Psychiatry, Middlesex Hospital Medical School, London, W.1
Leila Scotton
Affiliation:
Academic Department of Psychiatry, Middlesex Hospital Medical School, London, W.1
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Extract

It is a common clinical observation that emotional disturbance can influence a patient's response to sedative drugs. In recent years these effects have been studied in both normal and emotionally ill subjects. Kornetsky and Humphries (1957) found that in ten healthy adults the response to small doses of secobarbital sodium correlated with the scores on the depression and psychasthenia scales of the MMPI. Von Felsinger et al. (1955), in a study of the effect of a variety of psychotropic drugs, including pentobarbitone, on “normal” subjects, observed that those who responded in an atypical fashion tended to have abnormal personalities and to suffer from depressive episodes. Beecher (1955) has pointed out that the degree of placebo effect on post-operative analgesia varies with the severity of the stress to which the patient is exposed.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 114 , Issue 514 , September 1968 , pp. 1141 - 1147
Copyright
Copyright © Royal College of Psychiatrists, 1968 

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References

Ackner, B., and Pampiglione, G. (1959). “An evaluation of the sedation threshold test” J. psychosomat. Res., 3, 271–281.Google Scholar
Alexander, L. (1953). Treatment of Mental Disorder. Philadelphia: Saunders.CrossRefGoogle Scholar
Arduini, A., and Arduini, M. G. (1954). “Effect of drugs and metabolic alterations on brain stem arousal mechanism” J. Pharmacol., 110, 76–83.Google Scholar
Beecher, H. K. (1955). “Increased effectiveness of placebos” Amer. J. Physiol., 187, 163–169.Google Scholar
Bradley, P. B., and Key, B. J. (1958). “The effect of drugs on arousal responses produced by electrical stimulation of the reticular formation of the brain” Electroenceph. clin. Neurophysiol., 10, 97–110.CrossRefGoogle Scholar
Brazier, M. A. B. (1954). “The actions of anaesthetics on the nervous system.” In: Delafresnaye, J. P. (ed.) Brain Mechanisms and Consciousness. 163–199. Oxford: Blackwell Scientific Publications.Google Scholar
Brazier, M. A. B. (1961). “Some effects of anaesthesia on the brain” Brit. J. Anaesth., 33, 194–204.CrossRefGoogle Scholar
Brazier, M. A. B. (1963). “Role of the limbic system in maintenance of consciousness” Anaesth. Analg., 42, 748–751.Google Scholar
Chambers, W. F., Freedman, S. L., and Sawyer, C. H. (1963). “The effect of adrenal steroids on evoked reticular responses” Exp. Neurol., 8, 458–469.CrossRefGoogle Scholar
Claridge, G. S., and Harrington, R. N. (1960). “Sedation threshold, personality and the theory of neurosis” J. ment. Sri., 106, 1568–1583.Google Scholar
Cook, S., Mavor, H., and Chambers, W. F. (1960). “Effects of reticular stimulation in altered adrenal states” Electroenceph. clin. Neurophysiol., 12, 601.CrossRefGoogle Scholar
Dempsey, E. W., Morison, R. S., and Morison, B. R. (1940). “Some afferent diencephalic pathways related to cortical potentials in the cat” Amer. J. Physiol., 131, 718–731.CrossRefGoogle Scholar
Domino, E. F., Corssen, G., and Sweet, R. B. (1963). “Effects of various anaesthetics on the visually evoked response in man” Anaesth. Analg., 42, 735–746.Google Scholar
Eclin, F. A., Arret, V., and Zoll, J. (1952). “Paroxysmal high voltage discharges from isolated human and animal cerebral cortex” Electroenceph. clin. Neurophysiol., 4, 147–164.Google Scholar
Gallinek, A. (1956). “Fear and anxiety in the course of electroshock therapy” Amer. J. Psychiat., 113, 428–434.Google Scholar
Gibbons, J. L. (1965). “Metabolic function in affective disorders” Proc. Roy. Soc. Med., 58, 519–521.Google Scholar
Gibbons, J. L. (1966). “The secretion rate of corticosterone in depressive illness” J. psychosom. Res., 10, 263–266.CrossRefGoogle Scholar
Goldman, D. (1964). “Electroencephalographic manifestations associated with psychotic illness. Pentothal activation technique and pharmacologic interrelationships” Comp. Psychiat., 5, 80–92.Google Scholar
Henry, C. E., and Scoville, W. B. (1952). “Suppression-burst activity from isolated cerebral cortex in man” Electroenceph. clin. Neurophysiol., 4, 1–22.Google Scholar
Kiersey, D. K., Bickford, R. G., and Falconer, A. Jnr., (1951). “Electroencephalographic patterns produced by thiopentone sodium during surgical operations: description and classification” Brit. J. Anaesth., 23 141–152.CrossRefGoogle Scholar
Komiya, A., and Shibata, K. (1956). “Effect of adrenalectomy and replacement with adrenocortical steroids on barbital anaesthesia in mice” J. Pharmacol. exp. Therap., 116, 98–116.Google Scholar
Kornetsky, C., and Humphries, O. (1957). “Relationship between effects of a number of centrally acting drugs and personality” Arch. Neurol. Psychiat. (Chicago), 77, 325–327.CrossRefGoogle Scholar
Kirstein, L. (1954). “Suppression-burst activity during sleep” Electroenceph. clin. Neurophysiol., 6, 671–673.Google Scholar
Lindsley, D. B., Bowden, J. W., and Magoun, H. W. (1949). “Effect on the EEG of acute injury to the brain stem activating system” Ibid., 1, 475–486.Google Scholar
MacLean, P. D. (1955). “The limbic system (‘visceral brain’) and emotional behaviour” Arch. Neurol. Psychiat., 73, 130.CrossRefGoogle Scholar
Mayer-Gross, W., Slater, E., and Roth, M. (1960). Clinical Psychiatry. 740 p. London: Cassell.Google Scholar
Morison, R. S., and Dempsey, E. W. (1942). “A study of thalamo-cortical relations” Amer. J. Physiology, 135, 281–291.CrossRefGoogle Scholar
Nymgaard, K. (1959). “Studies on the sedation threshold. A. Reproducibility and effect of drugs. B. Sedation threshold in neurotic and psychotic depression” Arch. gen. Psychiat., 1, 530–536.Google Scholar
Pampiglione, G. (1962). “Electroencephalographic studies after cardiorespiratory resuscitation” Proc. Roy. Soc. Med., 55, 653–657.CrossRefGoogle Scholar
Robertson, J. D. (1963). “Intravenous anaesthesia.” In: Hewer, G. L. (ed.) pp. 30–78 Recent Advances in Anaesthesia and Analgesia. London: J. and A. Churchill Ltd.Google Scholar
Schneider, J., and Thomalske, G. (1956). “L'exploration pharmacodynamique cortico-sous-corticale et ses critères électrographiques. La détermination d'un foyer lésionnel chez l'homme par la technique pentothalique” Electroenceph. clin. Neurophysiol., 8, 353–369.Google Scholar
Seager, C. P. (1958). “Short periods of cortical silence occurring during light barbiturate anaesthesia” Ibid., 10, 158–161.Google Scholar
Shagass, G. (1954). “The sedation threshold: a method for estimating tension in psychiatric patients” Ibid., 6, 221–233.Google Scholar
Shagass, G. and Jones, A. L. (1958). “A neurophysiological test for psychiatric diagnosis: results in 750 patients” Amer. J. Psychiat., 114, 1002–1010.Google Scholar
Shagass, G., Mihalik, J., and Jones, A. L. (1957). “Clinical psychiatric studies using the sedation threshold” J. psychosomat. Res., 2, 45–55.CrossRefGoogle Scholar
Shagass, G., Muller, K., and Acosta, H. B. (1959). “Pentothal sleep threshold as an indicator of affective change” J. psychosomat. Res., 3, 253–270.Google Scholar
Shagass, G. and Naiman, J. (1955). “The sedation threshold, manifest anxiety and some aspects of ego function” Arch. Neurol. Psychiat. (Chicago), 74, 397–406.Google Scholar
Shagass, G. and Naiman, J. (1956). “The sedation threshold objective index of manifest anxiety in psychoneurosis” J. psychosomat. Res., 1, 49–57.CrossRefGoogle Scholar
Starzl, T. E., Taylor, C. W., and Magoun, H. W. (1951). “Ascending conduction in reticular activating system with special reference to the diencephalon” J. Neurophysiol., 14, 461–477.Google Scholar
Swank, R. L. (1949). “Synchronization of spontaneous electrical activity of cerebrum by barbiturate narcosis” Ibid., 12, 161–172.Google Scholar
Thorpe, J. G., and Barker, J. C. (1957). “Objectivity of the sedation threshold” Arch. Neurol. Psychiat. (Chicago), 78, 194–196.Google Scholar
Von Felsinger, J. M., Lasagna, L., and Beecher, H. K. (1955). “Drug-induced mood changes in man. Personality and reactions to drugs” J. Amer. med. Ass., 157, 1113–1119.CrossRefGoogle Scholar
Whitteridge, D., and Walsh, E. G. (1963). “The physiological basis of the electroencephalogram.” In: Hill, J. D. N., and Parr, G. (eds.) Electroencephalography: a Symposium on its Various Aspects. 99–146. Macdonald and Co. Google Scholar
Wilson, W. P., and Wilson, N.J. (1961). “Observations on the duration of photically elicited arousal responses in depressive psychosis” J. nerv. ment. Dis., 133, 438–440.CrossRefGoogle Scholar
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