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A mechanism of raft formation on both plasma membrane layers

Published online by Cambridge University Press:  08 October 2013

Kan Sornbundit ,
Charin Modchang ,
Wannapong Triampo ,
Darapond Triampo  and
Narin Nuttavut
Kan Sornbundit*
Affiliation:
Biophysics Group, Department of Physics, Faculty of Science, Mahidol University, Bangkok 10400, Thailand
Charin Modchang
Affiliation:
Biophysics Group, Department of Physics, Faculty of Science, Mahidol University, Bangkok 10400, Thailand
Wannapong Triampo
Affiliation:
Biophysics Group, Department of Physics, Faculty of Science, Mahidol University, Bangkok 10400, Thailand Institute for Innovative Learning, Mahidol University, Nakhon Pathom 73170, Thailand ThEP Center, CHE, 328 Si Ayutthaya Road, Bangkok 10400, Thailand
Darapond Triampo
Affiliation:
Department of Chemistry, Faculty of Science, Mahidol University, Bangkok 10400, Thailand
Narin Nuttavut*
Affiliation:
Biophysics Group, Department of Physics, Faculty of Science, Mahidol University, Bangkok 10400, Thailand
*
a e-mail: kans.mu@gmail.com
b e-mail: narinnuttavut@gmail.com
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Abstract

A double-layered membrane model is proposed to explain raft formation and induction on extracellular (outer) and cytoplasmic (inner) leaflets of plasma membranes in a situation where only the outer layer has a tendency to phase-separate. In the model, lipid exchange with the surrounding medium is allowed on both layers, but lipid exchange between layers is not allowed. Simulations display domain stabilization on both layers. The effect of the lipid recycling frequencies on stationary domain sizes is also investigated. It is found that stationary domain sizes decrease when lipid recycling frequencies are stronger. Linear stability analysis is used to verify the results.

Type
Research Article
Information
The European Physical Journal - Applied Physics , Volume 64 , Issue 1 , October 2013 , 11101
Copyright
© EDP Sciences, 2013

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