Hostname: page-component-7bb8b95d7b-495rp Total loading time: 0 Render date: 2024-09-06T06:52:39.984Z Has data issue: false hasContentIssue false
  • English
  • Français

Coexistence and function of glutamate receptor subtypes in the horizontal cells of the tiger salamander retina

Published online by Cambridge University Press:  02 June 2009

Xiong-Li Yang  and
Samuel M. Wu
Samuel M. Wu
Affiliation:
Cullen Eye Institute, Baylor College of Medicine, Houston
Get access Rights & Permissions [Opens in a new window]

Abstract

Effects of the major glutamate receptor agonists, kainate (KA), α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA), quisqualate (QA), N-methyl-D-aspartate (NMDA), L-α-amino-4-phosphonobutyrate (L-AP4), and trans-l-aminocyclopentane-1,3-dicarboxylic acid (ACPD) on horizontal cells (HCs) were studied in superfused larval tiger salamander retina. 20 μM of KA, AMPA, and QA mimicked the action of 3 mM glutamate in the absence and presence of 1 mM Co2+-20 μM 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) blocked the actions of KA and AMPA, but not those of QA and glutamate, indicative of the existence of CNQX-resistant QA receptors in the tiger salamander HCs. Prolonged application of ACPD hyperpolarized the HCs and enhanced the light responses, probably by shifting the resting HC voltage (Er) to a more hyperpolarized position. It is possible that the KA, AMPA, and CNQX-resistant QA receptors are involved in mediating the postsynaptic light responses in HCs, and ACPD receptors are involved in sensitivity adjustment of the HC responses.

Keywords

Kainateα-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)CNQX-resistant quisqualate receptortrans-l-aminocyclopentane-1,3-dicarboxylic acid (ACPD)L-α-amino-4-phosphonobutyrate (L-AP4)N-methyl-D-aspartate (NMDA)
Type
Research Articles
Information
Visual Neuroscience , Volume 7 , Issue 4 , October 1991 , pp. 377 - 382
Copyright
Copyright © Cambridge University Press 1991

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Attwell, D., Mobbs, P., Tessier-Lavigne, M. & Wilson, M. (1987). Neurotransmitters-induced currents in retinal bipolar cells of the axolotl (Ambystoma mexicanum). Journal of Physiology (London) 387, 125–161.Google Scholar
Biscoe, T.J., Evans, R.H., Headley, P.M., Martin, M.R. & Watkins, J.C. (1976). Structure-activity relationships of excitatory amino acids on frog and rat spinal neurones. British Journal of Pharmacology 58, 373–382.CrossRefGoogle ScholarPubMed
Choe, H.G. & Basinger, S.F. (1990). Glutamate receptor activation stimulates inositol phosphates release in frog retina. Investigative Ophthalmology and Visual Sciences (Suppl.) 31, 534.Google Scholar
Copenhagen, D.R. & Jahr, C.E. (1988). Release of excitatory amino acids from turtle photoreceptors detected with NMDA receptor-rich membrane patch. Investigative Ophthalmology and Visual Sciences (Suppl.) 29, 223.Google Scholar
Davies, J.D., Evans, R.H., Francis, A.A. & Watkins, J.C. (1979). Excitatory amino acid receptors and synaptic excitation in the mammalian central nervous system. Journal of Physiology 75, 641–654.Google ScholarPubMed
Davies, J.D. & Watkins, J.C. (1982). Actions of D and L forms of 2-aminophosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord. Brain Research 235, 378–386.CrossRefGoogle Scholar
Evans, R.H., Evans, S.J., Pook, P.C. & Sunter, D.C. (1987). A comparison of excitatory amino acid antagonists acting at primary afferent C fibers and motoneurons of the isolated spinal cord of the rat. British Journal of Pharmacology 91, 531–537.Google Scholar
Flatman, J.A., Schwindt, P.C., Crill, W.E. & Strafstrom, C.E. (1983). Multiple actions of N-methyl-D-aspartate on cat neocortical neurons in vitro. Brain Research 266, 169–173.Google Scholar
Johnson, J.W. & Ascher, P. (1987). Glycine potentiates the NMDA response in cultured mouse brain neurons. Nature 325, 529–531.Google Scholar
Kaneko, A. & Tachibana, M. (1985). Effects of L-glutamate on the anomalous rectifier potassium current in horizontal cells of Carassius auratus retina. Journal of Physiology 358, 169–182.CrossRefGoogle ScholarPubMed
Koerner, J.F. & Corman, C.W. (1981). Micromolar L-2-amino-4-phosphonobutyric acid selectively inhibits perforant path synapses from lateral entorhinal cortex. Brain Research 21, 192–198.Google Scholar
Krogsgaard-Larsen, P., Honore, T., Hansen, J.J., Curtis, D.R. & Lodge, D. (1980). New class of glutamate agonist structurally related to ibotenic acid. Nature 284, 64–66.CrossRefGoogle ScholarPubMed
Lasater, E.M. & Dowling, J.E. (1982). Carp horizontal cells in culture respond selectively to L-glutamate and its agonists. Proceedings of the National Academy of Sciences of the U.S.A. 79, 936–940.Google Scholar
MacDonald, J.F., Porietis, A.V., Wojtowicz, J.M. (1982). L-aspartic acid induces a region of negative slope conductance in the current voltage relationship of cultured spinal cord neurons. Brain Research 237, 248–253.Google Scholar
Marc, R.E. & Lam, D.M. (1981). Uptake of aspartic and glutamic acids by photoreceptors in the goldfish retina. Proceedings of the National Academy of Sciences of the U.S.A. 78, 7185–7189.Google Scholar
Mayer, M.L. & Westbrook, G.L. (1985). The action of N-methyl-D-aspartic acid on mouse spinal neurons in culture. Journal of Physiology 361, 65–90.CrossRefGoogle ScholarPubMed
Miller, R.F. & Slaughter, M.M. (1985). Excitatory amino-acid receptors in the vertebrate retina. In Retinal Transmitters and Modulators: Models for the Brain, Vol. 2, ed. Morgan, W.W., pp. 123–160. Boca Raton: CRC Press.Google Scholar
Mittman, S., Taylor, W.R. & Copenhagen, D.R. (1990). Concomitant activation of two types of glutamate receptors mediated excitation of salamander retinal ganglion cells. Journal of Physiology 428, 175–197.Google Scholar
Monaghan, D.T., Bridges, R.J. & Cotman, C.W. (1989). The excitatory amino acid receptors: their classes, pharmacology, and distinct properties in the function of the central nervous system. Annual Reviews of Pharmacology and Toxicology 29, 365–402.Google Scholar
Nawy, S. & Jahr, C.E. (1990). Suppression by glutamate of cGMP-activated conductance in retinal bipolarcells. Nature 346, 269–271.CrossRefGoogle Scholar
O'Dell, T.J. & Christensen, B.N. (1989). A voltage-clamp study of isolated stingray horizontal cell non-NMDA excitatory amino-acid receptors. Journal of Neurophysiology 61, 162–172.CrossRefGoogle ScholarPubMed
Rowe, J.S. & Ruddock, K.H. (1982). Depolarization of retinal horizontal cells by excitatory amino-acid neurotransmitter agonists. Neuroscience Letters 30, 257–262.CrossRefGoogle ScholarPubMed
Shinozaki, H. & Shibuya, I. (1974). New potent excitant, quisqualic acid—effects on crayfish neuromuscular junction. Neuropharmacology 13, 665–672.Google Scholar
Slaughter, M.M. & Miller, R.F. (1983a). An excitatory amino-acid antagonist blocks cone input to sight-conserving second-order retinal neurons. Science 219, 1230–1232.Google Scholar
Slaughter, M.M. & Miller, R.F. (1983b). Bipolar cells in the mud-puppy retina use an excitatory amino-acid neurotransmitter. Nature 303, 537–538.CrossRefGoogle Scholar
Slaughter, M.M. & Miller, R.F. (1981). 2-amino-4-phosphonobutyric acid: a new pharmacological tool for retina research. Science 211, 182–185.CrossRefGoogle ScholarPubMed
Sugiyama, H., Ito, I. & Hirono, C. (1987). A new type of glutamate receptor linked to inositol phospholipid metabolism. Nature 325, 531–533.Google Scholar
Wu, S.M. (1987). Synaptic connections among retinal neurons in living slices. Journal of Neuroscience Methods 20, 139–149.Google Scholar
Yang, X.L. & Wu, S.M. (1989a). Effects of background illumination on the horizontal cell responses in the tiger salamander retina. Journal of Neuroscience 9, 815–827.Google Scholar
Yang, X.L. & Wu, S.M. (1989b). Effects of CNQX, APB, PDA, and kynurenate on horizontal cells of the tiger salamander retina. Visual Neuroscience 3, 207–212.Google Scholar
Yang, X.L. & Wu, S.M. (1991). Feedforward lateral inhibition in retinal bipolar cells: input-output relation of the horizontal cell-depolarizing bipolar cell synapse. Proceedings of the National Academy of Sciences of the U.S.A. 88, 3310–3313.CrossRefGoogle ScholarPubMed