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Current source density analysis of contra- and ipsilateral isthmotectal connections of the frog

Published online by Cambridge University Press:  04 October 2006

NORIAKI HOSHINO ,
KAZUYA TSURUDOME ,
HIDEKI NAKAGAWA  and
NOBUYOSHI MATSUMOTO
NORIAKI HOSHINO
Affiliation:
Kyushu Institute of Technology, Graduate School of Life Science and Systems Engineering, Department of Brain Science and Engineering, Wakamatsu-ku, Kitakyushu, Fukuoka, Japan
KAZUYA TSURUDOME
Affiliation:
Kyushu Institute of Technology, Graduate School of Life Science and Systems Engineering, Department of Brain Science and Engineering, Wakamatsu-ku, Kitakyushu, Fukuoka, Japan
HIDEKI NAKAGAWA
Affiliation:
Kyushu Institute of Technology, Graduate School of Life Science and Systems Engineering, Department of Brain Science and Engineering, Wakamatsu-ku, Kitakyushu, Fukuoka, Japan
NOBUYOSHI MATSUMOTO
Affiliation:
Kyushu Institute of Technology, Graduate School of Life Science and Systems Engineering, Department of Brain Science and Engineering, Wakamatsu-ku, Kitakyushu, Fukuoka, Japan
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Abstract

The nucleus isthmi (NI) of the frog receives input from the ipsilateral optic tectum and projects back to both optic tecta. After ablation of NI, frogs display no visually elicited prey-catching or threat avoidance behavior. Neural mechanisms that underlie the loss of such important behavior have not been solved. Electrophysiological examination of the contralateral isthmotectal projection has proved that it contributes to binocular vision. On the other hand, there are very few physiological investigations of the ipsilateral isthmotectal projection. In this study, current source density (CSD) analysis was applied to contra- and ipsilateral isthmotectal projections. The contralateral projection produced monosynaptic sinks in superficial layers and in layer 8. The results confirmed former findings obtained by single unit recordings. The ipsilateral projection elicited a prominent monosynaptic sink in layer 8. Recipient neurons were located in layers 6–7. These results, combined with those from the former intracellular study, led to the following neuronal circuit. Afferents from the ipsilateral NI inhibit non-efferent pear shaped neurons in the superficial layers, and strongly excite large ganglionic neurons projecting to the descending motor regions. Thus feedback to the output neurons strengthens the visually elicited responses.

Keywords

Current source density (CSD) analysisNuclear isthmiIsthmotectal projectionOptic tectumFrog
Type
Research Article
Information
Visual Neuroscience , Volume 23 , Issue 5 , September 2006 , pp. 713 - 719
Copyright
2006 Cambridge University Press

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