Hostname: page-component-84b7d79bbc-2l2gl Total loading time: 0 Render date: 2024-08-04T06:51:57.415Z Has data issue: false hasContentIssue false
  • English
  • Français

Disturbed interhemispheric functional connectivity in visual pathway in individuals with unilateral retinal detachment: A resting state fMRI study

Published online by Cambridge University Press:  20 September 2018

QING YUAN ,
HONG-HUA KANG ,
WEN-QING SHI ,
YING-XIN GONG ,
TING SU ,
PEI-WEN ZHU ,
YOU-LAN MIN ,
LEI YE ,
NAN JIANG  and
YI SHAO Open the ORCID record for YI SHAO [Opens in a new window]
QING YUAN
Affiliation:
Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, People’s Republic of China
HONG-HUA KANG
Affiliation:
Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, People’s Republic of China
WEN-QING SHI
Affiliation:
Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, People’s Republic of China
YING-XIN GONG
Affiliation:
Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, People’s Republic of China
TING SU
Affiliation:
Eye Institute of Xiamen University, Xiamen, Fujian 361102, China
PEI-WEN ZHU
Affiliation:
Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, People’s Republic of China
YOU-LAN MIN
Affiliation:
Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, People’s Republic of China
LEI YE
Affiliation:
Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, People’s Republic of China
NAN JIANG
Affiliation:
Eye Institute of Xiamen University, Xiamen, Fujian 361102, China
YI SHAO*
Affiliation:
Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, People’s Republic of China
*
†Address correspondence to: Yi Shao, Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Clinical Ophthalmology Institute, 17 Yongwaizheng Street, Donghu, Nanchang, Jiangxi 330006, People’s Republic of China. E-mail: freebee99@163.com
Get access Rights & Permissions [Opens in a new window]

Abstract

Previous neuroimaging studies demonstrated that retinal detachment (RD) subjects were associated with abnormal spontaneous brain activities; however, whether the altered interhemispheric functional connectivity (FC) occurred in RD patients remains unknown. The current study tried to explore the alternations of interhemispheric FC of the whole brain in unilateral RD patients using the voxel-mirrored homotopic connectivity (VMHC) method and their connections to clinical features. Methods: We recruited 30 patients with RD (16 males and 14 females) and 30 healthy controls (HCs) (16 males and 14 females) whose age and sex were closely matched. All subjects underwent the rs-fMRI scans. The VMHC method was applied to directly assess the hemispheres’ functional interaction. The VMHC in these brain areas, which could be used as biomarkers to differentiate RD from HC, was identified by the receiver operating characteristic (ROC) curve analyses. The relations between these patients’ clinical features and their mean VMHC signal values in multiple brain regions were calculated by Pearson correlation analysis. Results: RD patients had significantly lower VMHC values than HCs in the bilateral occipital lobe (Brodmann areas, BA 18), bilateral superior temporal gyrus (BA 39), and bilateral cuneus (BA 19). Moreover, the mean VMHC signal values of the bilateral cuneus were in positive correlation with the duration of the RD (r = 0.446, P = 0.013). Conclusion: Our results provided an evidence of disturbed interhemispheric FC in the visual area occurred in RD patients, which might provide some useful information to understand the neural mechanism of RD patients with acute vision loss. Furthermore, the VMHC values might indicate the progress of the RD.

Keywords

Retinal detachmentVoxel-mirrored homotopic connectivityStatic conditionFunctional magnetic resonance imaging
Type
Research Article
Information
Visual Neuroscience , Volume 35 , 2018 , E026
Copyright
Copyright © Cambridge University Press 2018 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

*

These authors contributed equally to this work.

References

Atapour, N., Worthy, K.H., Lui, L.L., Yu, H.H. & Rosa, M.G.P. (2017). Neuronal degeneration in the dorsal lateral geniculate nucleus following lesions of primary visual cortex: Comparison of young adult and geriatric marmoset monkeys. Brain Structure and Function 222, 3283–3293.CrossRefGoogle ScholarPubMed
Chen, K.H. & Chen, L.R. (2013). Bilateral retinal detachment with subsequent blindness in a pregnant woman with severe pre-eclampsia. Taiwanese Journal of Obstetrics & Gynecology 52, 142–144.CrossRefGoogle Scholar
Chen, W. & Zhu, X.H. (2001). Correlation of activation sizes between lateal geniculate nucleus and primary visual cortex in humans. Magnetic Resonance in Medicine 45, 202–205.3.0.CO;2-S>CrossRefGoogle Scholar
Ellison, A., Schindler, I., Pattison, L.L. & Milner, A.D. (2004). An exploration of the role of the superior temporal gyrus in visual search and spatial perception using TMS. Brain 127, 2307–2315.CrossRefGoogle ScholarPubMed
Foubert, L., Bennequin, D., Thomas, M.A., Droulez, J. & Milleret, C. (2010). Interhemispheric synchrony in visual cortex and abnormal postnatal visual experience. Frontiers in Bioscience 15, 681–707.CrossRefGoogle ScholarPubMed
Guo, W., Liu, F., Xue, Z., Gao, K., Liu, Z., Xiao, C.Q., Chen, H.F. & Zhao, J.P. (2013). Decreased interhemispheric coordination in treatment-resistant depression: A resting-state fMRI study. PLoS One 8, e71368.CrossRefGoogle ScholarPubMed
Gharabaghi, A., Fruhmann Berger, M., Tatagiba, M. & Karnath, H.O. (2006). The role of the right superior temporal gyrus in visual search-insights from intraoperative electrical stimulation. Neuropsychologia 44, 2578–2581.CrossRefGoogle ScholarPubMed
Hou, F., Liu, X., Zhou, Z., Zhou, J. & Li, H. (2017). Reduction of interhemispheric functional brain connectivity in early blindness: A resting-state fMRI study. BioMed Research International 2017, 1–8.Google ScholarPubMed
Jiang, J., Gu, L., Bao, D., Hong, S.D., He, W., Tan, Y.M., Zeng, X.J., Gong, H.H., Zhang, D.Y. & Zhou, F.Q. (2016). Altered homotopic connectivity in postherpetic neuralgia: A resting state fMRI study. Journal of Pain Research 9, 877–886.CrossRefGoogle ScholarPubMed
Kapadia, M.K., Westheimer, G. & Gilbert, C.D. (2000). Spatial distribution of contextual interactions in primary visual cortex and in visual perception. Journal of Neurophysiology 84, 2048–2062.CrossRefGoogle ScholarPubMed
Liang, M., Xie, B., Yang, H., Yin, X., Wang, H., Yu, L., He, S. & Wang, J. (2017). Altered interhemispheric functional connectivity in patients with anisometropic and strabismic amblyopia: A resting-state fMRI study. Neuroradiology 59, 517–524.CrossRefGoogle ScholarPubMed
Lumi, X., Hawlina, M., Glavač, D., Facskó, A., Moe, M.C., Kaarniranta, K. & Petrovski, G. (2015). Ageing of the vitreous: From acute onset floaters and flashes to retinal detachment. Ageing Research Reviews 21, 71–77.CrossRefGoogle ScholarPubMed
Lo, A.C., Woo, T.T., Wong, R.L. & Wong, D. (2011). Apoptosis and other cell death mechanisms after retinal detachment: Implications for photoreceptor rescue. Ophthalmologica 226, 10–17.CrossRefGoogle ScholarPubMed
Murakami, T., Uji, A., Ogino, K., Unoki, N., Horii, T., Yoshitake, S., Nishijima, K. & Yoshimura, N. (2013). Association between perifoveal hyperfluorescence and serous retinal detachment in diabetic macular edema. Ophthalmology 120, 2596–2603.CrossRefGoogle ScholarPubMed
Manners, S., Ng, J.Q., Kemp-Casey, A., Chow, K., Kang, C.Y. & Preen, D.B. (2017). Retinal detachment surgery in Western Australia (2000–2013): A whole-population study. British Journal of Ophthalmology 101, 1679–1682.CrossRefGoogle ScholarPubMed
Mima, T., Oluwatimilehin, T., Hiraoka, T. & Hallett, M. (2001). Transient interhemispheric neuronal synchrony correlates with object recognition. Journal of Neuroscience 21, 3942–3948.CrossRefGoogle ScholarPubMed
Mesgarani, N., Cheung, C., Johnson, K. & Chang, E.F. (2014). Phonetic feature encoding in human superior temporal gyrus. Science 343, 1006–1010.CrossRefGoogle ScholarPubMed
Reale, R.A., Calvert, G.A., Thesen, T., Jenison, R.L., Kawasaki, H., Oya, H., Howard, M.A. & Brugge, J.F. (2007). Auditory-visual processing represented in the human superior temporal gyrus. Neuroscience 145, 162–184.CrossRefGoogle ScholarPubMed
Sarrazin, L., Averbukh, E., Halpert, M., Hemo, I. & Rumelt, S. (2004). Traumatic pediatric retinal detachment: A comparison between open and closed globe injuries. American Journal of Ophthalmology 137, 1042–1049.CrossRefGoogle ScholarPubMed
Schatz, P. & Andréasson, S. (2010). Recovery of retinal function after recent-onset rhegmatogenous retinal detachment in relation to type of surgery. Retina 30, 152–159.CrossRefGoogle Scholar
Sarrafizadeh, R., Hassan, T.S., Ruby, A.J., Williams, G.A., Garretson, B.R., Capone, A. Jr., Trese, M.T. & Margherio, R.R. (2001). Incidence of retinal detachment and visual outcome in eyes presenting with posterior vitreous separation and dense fundus-obscuring vitreous hemorrhage. Ophthalmology 108, 2273–2278.CrossRefGoogle ScholarPubMed
Tsujikawa, A., Kikuchi, M., Ishida, K., Nonaka, A., Yamashiro, K. & Kurimoto, Y. (2006). Fellow eye of patients with retinal detachment associated with macular hole and bilateral high myopia. Clinical and Experimental Ophthalmology 34, 430–433.CrossRefGoogle ScholarPubMed
Terauchi, G., Shinoda, K., Matsumoto, C.S., Watanabe, E., Matsumoto, H. & Mizota, A. (2015). Recovery of photoreceptor inner and outer segment layer thickness after reattachment of rhegmatogenous retinal detachment. British Journal of Ophthalmology 99, 1323–1327.CrossRefGoogle ScholarPubMed
Tong, F. (2003). Primary visual cortex and visual awareness. Nature Reviews Neuroscience 4, 219–229.CrossRefGoogle ScholarPubMed
Van de Put, M.A., Hooymans, J.M. & Los, L.I. (2013). The incidence of rhegmatogenous retinal detachment in The Netherlands. Ophthalmology 120, 616–622.CrossRefGoogle ScholarPubMed
Vinje, W.E. & Gallant, J.L. (2000). Sparse coding and decorrelation in primary visual cortex during natural vision. Science 287, 1273–1276.CrossRefGoogle ScholarPubMed
Wang, J., Zhou, T., Qiu, M., Du, A., Cai, K., Wang, Z., Zhou, C., Meng, M., Zhuo, Y., Fan, S. & Chen, L. (1999). Relationship between ventral stream for object vision and dorsal stream for spatial vision: An fMRI + ERP study. Human Brain Mapping 8, 170–181.3.0.CO;2-W>CrossRefGoogle ScholarPubMed
Yan, C.G. & Zang, Y.F. (2010). DPARSF: A MATLAB toolbox for “Pipeline” data analysis of resting-state fMRI. Frontiers in Systems Neuroscience 4, 13.Google Scholar
Zuo, X.N., Kelly, C., Di Martino, A., Mennes, M., Margulies, D.S., Bangaru, S., Grzadzinski, R., Evans, A.C., Zang, Y.F., Castellanos, F.X. & Milham, M.P. (2010). Growing together and growing apart: Regional and sex differences in the lifespan developmental trajectories of functional homotopy. Journal of Neuroscience 30, 15034–15043.CrossRefGoogle ScholarPubMed