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Effects of the dopamine antagonist (+)-SCH 23390 on intracellularly recorded responses of ganglion cells in the rabbit retina

Published online by Cambridge University Press:  02 June 2009

Ralph J. Jensen
Ralph J. Jensen
Affiliation:
Department of Biomedical Sciences, Southern College of Optometry, Memphis
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Abstract

The effects of the dopamine D1 antagonist (+)-SCH 23390 on the responses of ganglion cells in the superfused rabbit retinal preparation were studied by intracellular recording. At low micromolar concentrations, (+)-SCH 23390 hyperpolarized OFF-center brisk ganglion cells and reduced or abolished any spontaneous spike activity that was present. The light-evoked EPSPs at the onset of a spot or annulus were reduced or abolished, while the EPSPs at light offset were in most cases potentiated. (+)-SCH 23390 depolarized ON-center brisk ganglion cells and increased spontaneous spike activity. The light-evoked EPSPs to spots and annuli were either unaffected or reduced roughly to the same extent. The findings in this study are compared with findings in a recent study in which the effects of (+)-SCH 23390 on the extracellularly recorded responses of ganglion cells in the rabbit retina were examined.

Keywords

Rabbit retinaGanglion cellsDopamine D1 antagonistIntracellular recordings
Type
Research Articles
Information
Visual Neuroscience , Volume 8 , Issue 5 , May 1992 , pp. 463 - 467
Copyright
Copyright © Cambridge University Press 1992

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