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Normal eye-specific patterning of retinal inputs to murine subcortical visual nuclei in the absence of brain-derived neurotrophic factor

Published online by Cambridge University Press:  05 April 2005

ALVIN W. LYCKMAN ,
GUOPING FAN ,
MARIBEL RIOS ,
RUDOLF JAENISCH  and
MRIGANKA SUR
ALVIN W. LYCKMAN
Affiliation:
The Picower Center for Learning and Memory and the Department of Brain and Cognitive Sciences, MIT, Cambridge
GUOPING FAN
Affiliation:
The Whitehead Institute for Biomedical Research, Cambridge Current address: UCLA School of Medicine, Department of Human Genetics, Los Angeles, CA 90095
MARIBEL RIOS
Affiliation:
The Whitehead Institute for Biomedical Research, Cambridge Current address: Tufts University School of Medicine, Department of Neuroscience, Boston, MA 02135
RUDOLF JAENISCH
Affiliation:
The Whitehead Institute for Biomedical Research, Cambridge
MRIGANKA SUR
Affiliation:
The Picower Center for Learning and Memory and the Department of Brain and Cognitive Sciences, MIT, Cambridge
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Abstract

Brain-derived neurotrophic factor (BDNF) is a preferred ligand for a member of the tropomyosin-related receptor family, trkB. Activation of trkB is implicated in various activity-independent as well as activity-dependent growth processes in many developing and mature neural systems. In the subcortical visual system, where electrical activity has been implicated in normal development, both differential survival, as well as remodeling of axonal arbors, have been suggested to contribute to eye-specific segregation of retinal ganglion cell inputs. Here, we tested whether BDNF is required for eye-specific segregation of visual inputs to the lateral geniculate nucleus and the superior colliculus, and two other major subcortical target fields in mice. We report that eye-specific patterning is normal in two mutants that lack BDNF expression during the segregation period: a germ-line knockout for BDNF, and a conditional mutant in which BDNF expression is absent or greatly reduced in the central nervous system. We conclude that the availability of BDNF is not necessary for eye-specific segregation in subcortical visual nuclei.

Keywords

Optic tractNeurotrophic factorSynaptic specificityPlasticityCompetition
Type
Research Article
Information
Visual Neuroscience , Volume 22 , Issue 1 , January 2005 , pp. 27 - 36
Copyright
© 2005 Cambridge University Press

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