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A role for 5HT3 receptors in visual processing in the mammalian retina

Published online by Cambridge University Press:  02 June 2009

William J. Brunken  and
Xiao-Tao Jin
William J. Brunken
Affiliation:
Department of Biology, Boston College, Chestnut Hill
Xiao-Tao Jin
Affiliation:
Department of Biology, Boston College, Chestnut Hill
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Abstract

We investigated the role of 5HT3 receptors in the mammalian retina using electrophysiological techniques to monitor ganglion cell activity. Activation of 5HT3 receptors with the selective agonist 1-phenylbiguanide (PBG) increased the ON responses of ON-center ganglion cells, while decreasing the OFF responses of OFF-center cells. The application of a selective 5HT3 antagonist had a reciprocal effect, namely it reduced the center response in ON-center cells and concomitantly increased the center responses in OFF-center cells. Since putative serotoninergic amacrine cells in the retina are connected specifically to the rod bipolar cell, these agents most likely affect the rod bipolar terminal. These data, together with previous studies, suggest that both 5HT2 and 5HT3 receptors mediate an excitatory influence which serves to facilitate the output from rod bipolar cells, the former via a phosphatidyl inositol second-messenger system, and the latter via a direction channel.

Keywords

RetinaSerotoninRabbitGanglion cells5HT3 receptorsRod pathways
Type
Articles
Information
Visual Neuroscience , Volume 10 , Issue 3 , May 1993 , pp. 511 - 522
Copyright
Copyright © Cambridge University Press 1993

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