Several dozen herbicide systems were evaluated over a 4-yr period for weed control in stubble no-till planted corn (Zea mays L.). Crop tolerance and corn yield data also were obtained. Paraquat (1,1′-dimethyl-4,4′-bipyridinium ion) and glyphosate [N-(phosphonomethyl)glycine] afforded excellent desiccation of all emerged vegetation each year. The oil-soluble formulation of dinoseb (2-sec-butyl-4,6-dinitrophenol) also afforded complete contact control of emerged vegetation in 1975, the only year it was evaluated. A herbicide system consisting of an acetanilide plus a triazine afforded the most consistent residual weed control. The specific herbicides affording satisfactory control largely depended on the weed spectrum. Fall panicum (Panicum dichotomiflorum Michx.), large crabgrass [Digitaria sanguinalis (L.) Scop.], and yellow nutsedge (Cyperus esculentus L.) were the weeds most difficult to control with the herbicide systems used in these studies. Corn yields were influenced primarily by the degree of weed control achieved, and in several instances by secondary effects of stand reduction or injury.