We investigated the toxicity of MSMA (monosodium methanearsonate), fluometuron [1,1-dimethyl-3-(α,α,α-trifluoro-m-tolyl)urea], and propanil (3′,4′-dichloropropionanilide) to soybeans [Glycine max (L.) Merr. ‘Hill’]. Over-the-top treatments were applied to soybeans at four stages of growth using MSMA at 0.1, 0.2, and 0.4 kg/ha, propanil at 0.2, 0.4, and 0.9 kg/ha, and fluometuron at 0.05, 0.1, and 0.2 kg/ha. Each herbicide caused 10 to 30% soybean injury at the lowest rate, and 40 to 70% injury at the highest rate. Soybeans treated earliest in the growing season usually recovered from injury better than soybeans treated later in the season. Soybean yields were reduced 50 to 70% by MSMA at 0.4 kg/ha and 25 to 35% by propanil at 0.9 kg/ha. Yield losses increased with stage of soybean maturity at time of treatment. Fluometuron at 0.2 kg/ha significantly reduced yield only when applied to soybeans with 7 or 10 trifoliolates or in midbloom.