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Chicken heterophils: a model for non-oxidative antimicrobial activity

Published online by Cambridge University Press:  23 December 2009

O. BENNOUNE ,
M. MELIZI ,
K. KHAZAL ,
R. BOUROUBA  and
A. AYACHI
O. BENNOUNE*
Affiliation:
Laboratory of health, animal production and environment (ESPA), Department of Veterinary Medicine, Faculty of Science, University of Batna, Algeria
M. MELIZI
Affiliation:
Laboratory of health, animal production and environment (ESPA), Department of Veterinary Medicine, Faculty of Science, University of Batna, Algeria
K. KHAZAL
Affiliation:
School of veterinary medicine, Tuskegee University, Tuskegee Alabama, AL 36088, USA
R. BOUROUBA
Affiliation:
Department of Biology, Faculty of Science, University of Batna, Algeria
A. AYACHI
Affiliation:
Laboratory of health, animal production and environment (ESPA), Department of Veterinary Medicine, Faculty of Science, University of Batna, Algeria
*
Corresponding author: bennouneo@yahoo.fr
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Abstract

Chicken heterophils are major components of the innate immune system and constitute the first guard of defence against invading microorganisms. Heterophils in contrast to mammalian neutrophils, lack myeloperoxidase, an essential enzyme of oxidative antimicrobial activity and their antimicrobial activity depends mainly on the non–oxidative mechanism. Heterophils are equipped with very efficient non–oxidative mechanism against microorganisms where the cationic antimicrobial peptides are the most powerful molecules of this killing activity with their broad spectrum activity and the ability to kill microorganisms even with very small concentrations may constitute a new antibiotic class and the basis for new feed additives. These polymorphonuclar cells are the best model for killing activity based on oxygen independent mechanisms. Disorders in the non-oxidative antimicrobial activity induced either by genetic mutations or immunomodulation diseases have direct effect on the killing capacity of heterophils. This review focuses on the heterophils main activity, cationic antimicrobial peptides isolated from chicken heterophils with their remarkable antimicrobial activity and the protective effect of heterophils in different states.

Keywords

heterophilschickenantimicrobialcationic peptides
Type
Review Article
Information
World's Poultry Science Journal , Volume 65 , Issue 4 , December 2009 , pp. 625 - 632
Copyright
Copyright © World's Poultry Science Association 2009

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