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In the defence against hyperglycamiea: an avian strategy

Published online by Cambridge University Press:  18 September 2007

H. Klandorf ,
I.L. Probert  and
M. Iqbal
H. Klandorf*
Affiliation:
Division of Animal and veterinary Sciences, West Virginia University, P.O. Box 6108, Morgantown, WV 26506–6108, USA
I.L. Probert
Affiliation:
Division of Animal and veterinary Sciences, West Virginia University, P.O. Box 6108, Morgantown, WV 26506–6108, USA
M. Iqbal
Affiliation:
Division of Animal and veterinary Sciences, West Virginia University, P.O. Box 6108, Morgantown, WV 26506–6108, USA Center of Excellence for poultry, University of Arkansas, Fayetteville, AR 72701, USA
*
Correspondence to Dr Hillar Klandorf.
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Abstract

Birds live longer than mammals of comparable sizes, contrary to what their metabolic rates, plasma gulcose concentrations and body tempratures, all of which are higher than mammalian norms, would suggest. Although these factors should predispose them to accelerated tissue degeneration, this has been shown not to happen. In this paper the possible mechanism whereby birds limit the accelerated tissue damage that should be associated with the above characteristics are explored. Specifically, this review will focus on the relationship in chickens between the raised concentrations of plasma glucose and the lack of associated tissue complications. We propose that the role of uric acid in birds should be re-examined. Until now uric acid has been considered to be little more than an excretory by-product where its role as an antioxidant can be directly linked to the resistance of birds to glucose-mediated tissue damage. It is suggested that, compared with mammals, the lower rate of generation of reactive oxygen species in birds in association with their stronger antioxidant-defence system contributes to their longevity.

Keywords

Birdshyperglycamieafree radicalsoxidative stresslongevityutric acidAGEspentosidine
Type
Research Article
Information
World's Poultry Science Journal , Volume 55 , Issue 3 , September 1999 , pp. 251 - 268
Copyright
Copyright © Cambridge University Press 1999

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