Hostname: page-component-848d4c4894-cjp7w Total loading time: 0 Render date: 2024-07-03T12:41:29.189Z Has data issue: false hasContentIssue false
  • English
  • Français

Quercetin: Nutritional and beneficial effects in poultry

Published online by Cambridge University Press:  20 April 2017

M. SAEED ,
M. NAVEED ,
M.A. ARAIN ,
M. ARIF ,
M.E. ABD EL-HACK ,
M. ALAGAWANY ,
F.A. SIYAL ,
R.N. SOOMRO  and
C. SUN
M. SAEED
Affiliation:
Department of Animal Nutrition, College of Animal Science and Technology, Northwest A&F University, Yangling Shaanxi 712100, P.R. China Institute of Animal Sciences, University of Agriculture Faisalabad, Pakistan38040
M. NAVEED
Affiliation:
Department of Clinical Pharmacy, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu Province, 211198, China Faculty of Pharmacy and Alternative MedicineThe Islamia University of BahawalpurPakistan63100
M.A. ARAIN
Affiliation:
College of Animal Sciences and Technology, Northwest A&F University, Yangling 712100, China Faculty of Veterinary and Animal Sciences, Lasbela University of Agriculture Water and Marine Sciences Uthal, Pakistan, 3800
M. ARIF
Affiliation:
Department of Animal Sciences, College of Agriculture, University of Sargodha, Pakistan
M.E. ABD EL-HACK
Affiliation:
Department of Poultry, Faculty of Agriculture, Zagazig University, Zagazig, 44511, Egypt
M. ALAGAWANY*
Affiliation:
Department of Poultry, Faculty of Agriculture, Zagazig University, Zagazig, 44511, Egypt
F.A. SIYAL
Affiliation:
Department of Animal Nutrition, Faculty of Animal Husbandry and Veterinary Sciences, Sindh Agriculture University Tando Jam, Pakistan70060
R.N. SOOMRO
Affiliation:
College of Animal Sciences and Technology, Northwest A&F University, Yangling 712100, China
C. SUN*
Affiliation:
College of Animal Sciences and Technology, Northwest A&F University, Yangling 712100, China
*
Corresponding authors: sunchao2775@163.com; dr.mahmoud.alagwany@gmail.com
Corresponding authors: sunchao2775@163.com; dr.mahmoud.alagwany@gmail.com
Get access

Abstract

Flavonoids are natural compounds derived from fruits, vegetables and medicinal plants. These compounds have been reported to possess various biological actions including anti-inflammatory, antioxidant, growth promoter, antiviral, hepatoprotective, antibacterial, antiallergic, anticarcinogenic, antithrombotic and immunomodulator activities in various animals and poultry species. Quercetin is found in various foods such as vegetables, tea, fruits, wine apples and onions and is known to exert positive effects on poultry production and health. Since, quercetin enhances the immune system by stimulating lymphocytes, macrophages and IgY antibody production and improving natural killer cell activity, lymphoid organs (spleen, thymus and bursa) weights as well as activating the cytokines profile, its supplementation can lead to a state of immune alertness and a lower incidence of infections and diseases. In addition, it affects the dendritic cells (DCs) that play an important role in adaptive and innate immunity. Quercetin revokes the ability of lipopolysaccharide (LPS)-stimulated dendritic cells to induce specific T cell activation and reduce the cytotoxicity in both in vivo and in vitro studies, suggesting quercetin works as an immunosuppressive agent. As immune function is crucial for poultry productivity and prosperity, this review elucidates the potential nutritional effects and health benefits of quercetin on poultry as a replacer for traditional immune boosters and growth promoters. It includes the antiviral activity of quercetin against influenza A virus, rhinovirus (caused common cold), adenovirus (source of necrotic pancreatitis in broilers) and suggests its role in counteracting heavy metal toxicity. However, further studies on molecular basis are required to understand mode of action, beneficial applications as a natural feed additive, growth promoter and immune enhancer, beside the side effects of this compound in poultry.

Keywords

flavonoidsquercetinchemical structurebeneficial aspectshealthpoultry
Type
Reviews
Information
World's Poultry Science Journal , Volume 73 , Issue 2 , June 2017 , pp. 355 - 364
Copyright
Copyright © World's Poultry Science Association 2017 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

ABAZA, I.M., SHEHETA, M.A., SHOEB, M.S. and HASSAN, I.I. (2008) Evaluation of some natural feed additives in growing chicks’ diets. International Journal of Poultry Science 7: 872-879.CrossRefGoogle Scholar
ADER, P., WESSMANN, A. and WOLFFRAM, S. (2000) Bioavailability and metabolism of the flavonol quercetin in the pig. Free Radical Biology and Medicine 28: 1056-1067.CrossRefGoogle ScholarPubMed
ADES, T.B. (2009) Quercetin. American Cancer Society Complete Guide to Complementary and Alternative Cancer Therapies (2nd ed.). American Cancer Society. ISBN 9780944235713.Google Scholar
ALAGAWANY, M., ASHOUR, E.A. and REDA, F.M. (2016) Effect of dietary supplementation of garlic (Allium sativum) and turmeric (Curcuma longa) on growth performance, carcass traits, blood profile and oxidative status in growing rabbits. Annals of Animal Science 16: 489-505.CrossRefGoogle Scholar
ALRAWAIQ, N.S. and ABDULLAH, A.A. (2014) Review of flavonoid quercetin: metabolism, bioactivity and antioxidant properties. International Journal of Pharm Tech Research 6: 933-941.Google Scholar
ANONYMOUS (2014) USDA database for the flavonoid content of selected foods—Released and slightly revised in May 2014. http://www.ars.usda.gov/News/docs.htm?docid=6231.Google Scholar
BENTZ, A.B. (2009) A review of quercetin: chemistry, antioxidant properties, and bioavailability. Journal of Young Investigators 6: 391-415.Google Scholar
BHAGWAT, S., HAYTOWITS, D.B. and HOLDEN, J.M. (2011) USDA Database for the Flavonoid Content of Selected Foods, Release 3; U.S. Department of Agriculture: Beltsville, MD, USA.Google Scholar
CASTANON, J.I.R. (2007) History of the use of antibiotic as growth promoters in European poultry feeds. Poultry Science 86: 2466-2471.CrossRefGoogle ScholarPubMed
CHIRUMBOLO, S. (2010) The role of quercetin, flavonols and flavones in modulating inflammatory cell function. Inflammation and Allergy Drug Targets 9: 263-285.CrossRefGoogle ScholarPubMed
CHOI, H.J., SONG, J.H., PARK, K.S. and KWON, D.H. (2009) Inhibitory effects of quercetin 3-rhamnoside on influenza A virus replication. European Journal of Pharmaceutical Sciences 37: 329-333.CrossRefGoogle ScholarPubMed
COMALADA, M., BALLESTER, I., BAILON, E., XAUS, J., GALVEZ, J., DE MEDINA, F.S. and ZARZUELO, A. (2006) Inhibition of pro-inflammatory markers in primary bone marrow-derived mouse macrophages by naturally occurring flavonoids: analysis of the structure-activity relationship. Biochemical Pharmacology 72: 1010-1021.CrossRefGoogle ScholarPubMed
CRESPY, V., MORAND, C. and MANACH, C. (1999) Part of quercetin absorbed in the small intestine is conjugated and further secreted in the intestinal l: Umen. American Journal of Physiology 277: G120-G126.Google Scholar
DAY, A.J., BAO, Y., MORGAN, M.R. and WILLIAMSON, G. (2000) Conjugation position of quercetin glucuronides and effect on biological activity. Free Radical Biology and Medicine 29: 1234-1243.CrossRefGoogle ScholarPubMed
DHAMA, K., LATHEEF, S.K., MANI, S., ABDUL SAMAD, H., KARTHIK, K., TIWARI, R., KHAN, R.U., ALAGAWANY, M., FARAG, M.R., ALAM, G.M., LAUDADIO, V. and TUFARELLI, V. (2015) Multiple beneficial applications and modes of action of herbs in poultry health and production. A Review. International Journal of Pharmacology 11: 152-176.CrossRefGoogle Scholar
EXON, J.H., MAGNUSON, B.A., SOUTH, E.H. and HENDRIX, K. (1998) Dietary quercetin, immune functions and colonic carcinogenesis in rats. Immunopharmacology and Immunotoxicology 20: 173-190.CrossRefGoogle ScholarPubMed
FELLENBERG, M.A. and SPEISKY, H. (2006) Antioxidants: their effects on broiler oxidative stress and its meat oxidative stability. World's Poultry Science Journal 62: 53-70.CrossRefGoogle Scholar
GANESAN, S., FARIS, A.N., COMSTOCK, A.T., WANG, Q., NANUA, S., HERSHENSON, M.B. and SAJJAN, U.S. (2012) Quercetin inhibits rhinovirus replication in vitro and in vivo . Antiviral Research 94: 258-271.CrossRefGoogle ScholarPubMed
GOLIOMYTIS, M., ORFANOU, H., PETROU, E., CHARISMIADOU, M.A., SIMITZIS, P.E. and DELIGEORGIS, S.G. (2014) Effect of hesperidin dietary supplementation on hen performance, egg quality and yolk oxidative stability. British Poultry Science 55: 98-104.CrossRefGoogle ScholarPubMed
HAGER-THEODORIDES, A.L., GOLIOMYTIS, M., DELIS, S. and DELIGEORGIS, S. (2014) Effects of dietary supplementation with quercetin on broiler immunological characteristics. Animal Feed Science and Technology 198: 224-230.CrossRefGoogle Scholar
HODEK, P., TREFIL, P. and STIBOROVA, M. (2002) Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P450. Chemical-Biological Interactions 139: 1-21 CrossRefGoogle ScholarPubMed
HUANG, R.Y., YU, Y.L., CHENG, W.C., OUYANG, C.N., FU, E. and CHU, C.L. (2010) Immunosuppressive effect of quercetin on dendritic cell activation and function. Journal of Immunology 184: 6815-6821.CrossRefGoogle ScholarPubMed
IQBAL, M., CAWTHON, D., BEERS, K., WIDEMAN, R.F. (Jr) and BOTTJE, W.G. (2002) Antioxidant enzyme activities and mitochondrial fatty acids in pulmonary hypertension syndrome (PHS) in broilers. Poultry Science 81: 252-260.CrossRefGoogle ScholarPubMed
KAMBOH, A.A. and ZHU, W.Y. (2014) Individual and combined effects of genistein and hesperidin on immunity and intestinal morphometry in lipopolysacharide-challenged broiler chickens. Poultry Science 93: 1-9.CrossRefGoogle ScholarPubMed
KAMBOH, A.A. and ZHU, W.Y. (2013) Effect of increasing levels of bioflavonoids in broiler feed on plasmaanti-oxidative potential, lipid metabolites and fatty acid composition of meat. Poultry Science 92: 454-461.CrossRefGoogle ScholarPubMed
KIM, A.R., CHO, J.Y., ZOU, Y., CHOI, J.S. and CHUNG, H.Y. (2005) Flavonoids differentially modulate nitric oxide production pathways in lipopolysaccharideactivated RAW264.7 cells. Archives of Pharmacological Research 28: 297-304.CrossRefGoogle ScholarPubMed
KIM, D.H., KIM, S.Y., PARK, S.Y. and HAN, M.J. (1999) Metabolism of quercetin by human intestinal bacteria and its relation to some biological activities. Biological and Pharmaceutical Bulletin 22: 749-751.CrossRefGoogle ScholarPubMed
KIM, D.W., HONG, E.C., KIM, J.H., BANG, H.T., CHOI, J.Y., JI, S.Y., LEE, W.S. and KIM, S.H. (2015) Effects of dietary quercetin on growth performance, blood biochemical parameter, immunoglobulin and blood antioxidant activity in broiler chicks. Korean Journal of Poultry Science 42: 33-40.CrossRefGoogle Scholar
KOLI, R., ERLUND, I., JULA, A., MARNIEMI, J., MATTILA, P. and ALFTHAN, G. (2010) Bioavailability of various polyphenols from a diet containing moderate amounts of berries. Journal of Agriculture and Food Chemistry 58: 3927-3932.CrossRefGoogle ScholarPubMed
KONRAD, M., NIEMAN, D.C., HENSON, D.A., KENNERLY, K.M., JIN, F. and WALLNER-LIEBMANN, S.J. (2011) The Acute Effect of Ingesting a Quercetin-Based Supplement on Exercise-Induced Inflammation and Immune Changes in Runners. International Journal of Sport Nutrition and Exercise Metabolism 21: 338-346.CrossRefGoogle ScholarPubMed
KORVER, D. (2012) Implications of changing immune function through nutrition in poultry. Animal Feed Science and Technology 173: 54-64.CrossRefGoogle Scholar
KUMAZAWA, Y., KAWAGUCHI, K. and TAKIMOTO, H. (2006) Immunomodulating effects of flavonoids on acute and chronic inflammatory responses caused by tumornecrosis factor alpha. Current Pharmaceutical Design 12: 4271-4279.CrossRefGoogle Scholar
LARSON, A.J. SYMONS, J.D. and JALILI, T. (2012) Therapeutic potential of quercetin to decrease blood pressure: review of efficacy and mechanisms. Advances in Nutrition 3:39-46.CrossRefGoogle ScholarPubMed
LEE, C.K., PARK, K.K., HWANG, J.K., LEE, S.K. and CHUNG, W.Y. (2007) The extract of Prunus persica flesh (PPFE) attenuates chemotherapy-induced hepatotoxicity in mice. Phytotherapy Research 22: 223-227.CrossRefGoogle Scholar
LEE, K.H., PARK, E., LEE, H.J., KIM, M.O., CHA, Y.J., KIM, J.M., LEE, H. and SHIN, M.J. (2011) Effects of daily quercetin-rich supplementation on cardiometabolic risks in male smokers. Nutrition Research and Practice 66: 163-171.Google Scholar
LIU, H., ZHANG, L. and LU, S. (2012) Evaluation of antioxidant and immunity activities of quercetin in isoproterenol-treated rats. Molecules 17: 4281-4291.CrossRefGoogle ScholarPubMed
LIU, H.N., LIU, Y., HU, L.L., SUO, Y.L., ZHANG, L., JIN, F., FENG, X.A., TENG, N. and LI, Y. (2013) Effects of dietary supplementation of quercetin on performance, egg quality, cecal microflora populations, and antioxidant status in laying hens. Poultry Science 93:347-353.CrossRefGoogle Scholar
MALESER, D. and KUNTIC, V. (2007) Investigation of metal-flavonoid chelates and the determination of flavonoids via metal-flavonoid complexing reactions. Journal of the Serbian Chemical Society 72: 921-939.CrossRefGoogle Scholar
MANACH, C., SCALBERT, A., MORAND, C., REMESY, C. and JIMENEZ, L. (2004) Polyphenols: food sources and bioavailability. American Journal of Clinical Nutrition 79: 727-747.CrossRefGoogle ScholarPubMed
MANACH, C., TEXIER, O., MORAND, C., CRESPY, V., RÉGÉRAT, F., DEMIGNÉ, C. and RÉMÉSY, C. (1999) Comparison of the bioavailability of quercetin and catechin in rats. Free Radical Biology and Medicine 27: 1259-1266.CrossRefGoogle ScholarPubMed
MIN, Y.D., CHOI, C.H., BARK, H., SON, H.Y., PARK, H.H., LEE, S., PARK, J.W., PARK, E.K., SHIN, H.I. and KIM, S.H. (2007) Quercetin inhibits expression of inflammatory cytokines through attenuation of NF-kB and p38 MAPK in HMC-1 human mast cell line. Inflammation Research 56: 210-215.CrossRefGoogle ScholarPubMed
MOREIRA, M.R., KANASHIRO, A., KABEYA, L.M., POLIZELLO, A.C., AZZOLINI, A.E., CURTI, C., OLIVEIRA, C.A., T-DO AMARAL, A. and LUCISANO-VALIM, Y.M. (2007) Neutrophil effector functions triggered by Fc-g and/or complement receptors are dependent on B-ring hydroxylation pattern and physicochemical properties of flavonols. Life Science 81: 317-326.CrossRefGoogle ScholarPubMed
NISHIMURO, H., OHNISHI, H., SATO, M., OHNISHI-KAMEYAMA, M., MATSUNAGA, I., NAITO, S., IPPOUSHI, K., OIKE, H., NAGATA, T. and AKASAKA, H. (2015) Estimated daily intake and seasonal food sources of quercetin in Japan. Nutrients 7: 2345-2358.CrossRefGoogle ScholarPubMed
ORSOLIC, N., KNEZEVIC, A.H., SVER, L., TERZIC, S. and BASIC, I. (2004) Immunomodulatory and antimetastatic action of propolis and related polyphenolic compounds. Journal of Ethnopharmacology 94: 307-315.CrossRefGoogle ScholarPubMed
PETRUS, K., SCHWARTZ, H. and SONTAG, G. (2011) Analysis of flavonoids in honey by HPLC coupled with coulometric electrode array detection and electrospray ionisation mass spectrometry. Analytical and Bioanalytical Chemistry 400: 2555-2563.CrossRefGoogle Scholar
PIETTA, P.G. (2000) Flavonoids as antioxidants. Journal of Natural Product 63: 1035-1042.CrossRefGoogle ScholarPubMed
PROCHÁZKOVÁ, D., BOUŠOVÁ, I. and WILHELMOVÁ, N. (1999) Antioxidant and prooxidant properties of quercetin, myricetin, and kaempferol in 25 edible berries. Journal of Agriculture and Food Chemistry 47: 2274-2279.Google Scholar
REN-YEONG, H., YU, Y.L., CHENG, W.C., YANG, C.N.O., FU, E., HUANG, C.R.Y., YU, Y.L., CHENG, W.C., YANG, C.N.O., FU, E. and CHU, C.L. (2010) Immunosuppressive Effect of Quercetin on Dendritic Cell Activation and Function. The Journal of Immunology 184: 6815-6821.Google Scholar
RUPASINGHE, H.P.V., RONALDS, C.M., RATHGEBER, B. and ROBINSON, R.A. (2010) Absorption and tissue distribution of dietary quercetin and quercetin glycosides of apple skin in broiler chickens. Journal of Science Food and Agriculture 90: 1172-1178.CrossRefGoogle ScholarPubMed
SAMPSON, L., RIMM, E., HOLLMAN, P.C., DE VRIES, J.H. and KATAN, M.B. (2002) Flavonol and flavone intakes in US health professionals. Journal of the American Dietetic Association 102: 1414-1420.CrossRefGoogle ScholarPubMed
SERAFINI, M., PELUSO, I. and RAGUZZINI, A. (2010) Session 1: antioxidants and the immune system. Flavonoids as anti-inflammatory agents. Proceedings of the Nutrition Society 69: 273-278.CrossRefGoogle Scholar
SMITH, C., LOMBARD, K.A., PEFFLEY, E.B. and LIU, W. (2003) Genetic analysis of quercetin in onion (Allium cepa L.) Lady Raider. Texas Journal of Agriculture and Natural Resources 16: 24-28.Google Scholar
SOHAIB, M., BUTT, M.S., ANJUM, F.M., KHAN, M.I. and SHAHID, M. (2016) Augmentation of oxidative stability, descriptive Sensory attributes and quality of meat nuggets from broilers by dietary quercetin and Alpha-tocopherol regimens. Journal of food processing and preservation 40 (3): 373-385.CrossRefGoogle Scholar
SOMERSET, S.M. and JOHANNOT, L. (2008) Dietary flavonoid sources in Australian adults. Nutrition and Cancer 60: 442-449.CrossRefGoogle ScholarPubMed
TSUJI, M., YAMAMOTO, H., SATO, T., MIZUHA, Y., KAWAI, Y., TAKETANI, Y., KATO, S., TERAO, J., INAKUMA, T. and TAKEDA, E. (2009) Dietary quercetin inhibits bone loss without effect on the uterus in ovariectomized mice. Journal of Bone and Mineral Metabolism 27: 673-681.CrossRefGoogle ScholarPubMed
WICZKOWSKI, W., ROMASZKO, J., BUCINSKI, A., SZAWARA-NOWAK, D., HONKE, J., ZIELINSKI, H. and PISKULA, M.K. (2008) Quercetin from shallots (Allium cepa L. var. aggregatum) is more bioavailable than its glucosides. Journal of Nutrition 138: 885-888.CrossRefGoogle ScholarPubMed
YOUDIM, K.A., QAISER, M.Z. and BEGLEY, D.J. (2004) Flavonoid permeability across an in situ model of the blood-brain barrier. Free Radical Biology and Medicine 36: 592-604.CrossRefGoogle Scholar
YU, E.S., MIN, H.J., AN, S.Y., WON, H.Y., HONG, J.H. and HWANG, E.S. (2008) Regulatory mechanisms of IL-2 and IFNg suppression by quercetin in T helper cells. Biochemistry Pharmacology 76: 70-78.CrossRefGoogle Scholar