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Rhinocerebral aspergillosis

Published online by Cambridge University Press:  29 June 2007

Mohan Kameswaran ,
Abdulla Al-Wadei ,
Praful Khurana  and
B. C. Okafor
Mohan Kameswaran*
Affiliation:
Departments of Otolaryngology, King Saud UniversityCollege of Medicine and Asir Central Hospital, Abha, Saudi Arabia.
Abdulla Al-Wadei
Affiliation:
Departments of Otolaryngology, King Saud UniversityCollege of Medicine and Asir Central Hospital, Abha, Saudi Arabia.
Praful Khurana
Affiliation:
Departments of Pathology, King Saud University, College of Medicine and Asir Central Hospital, Abha, Saudi Arabia.
B. C. Okafor
Affiliation:
Departments of Otolaryngology, King Saud UniversityCollege of Medicine and Asir Central Hospital, Abha, Saudi Arabia.
*
Assistant Professor, College of Medicine, P.O. Box 641, King Saud University, Abha, Saudi Arabia.
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Abstract

Aspergillosis is increasingly being recognised as a common fungal infection of the paranasal sinuses. Although the disease is almost endemic in neighbouring Sudan, there are few reported cases from the Kingdom of Saudi Arabia. We report four cases of sinus aspergillosis with involvement of the skull bases and/or intracranial spread; a condition we have termed rhinocerebral aspergillosis. Invasive aspergillosis in our subgroup of patients occurs in otherwise healthy patients with normal immune status, quite unlike most reported cases in the western literature. The causative agent in all our patients was identified as aspergillus flavus, similar to patients reported from Sudan. This is again at variance with the case reports from other geographical locations, where aspergillus fumigatus is the commonest causative agent. Saudi Arabia would appear to represent a distinct geographical enclave, together with Sudan, where rhinocerebral aspergillosis of the sinuses and skull base may be more common than has previously been realised.

Keywords

Aspergillosisrhinocerebral
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 106 , Issue 11 , November 1992 , pp. 981 - 985
Copyright
Copyright © JLO (1984) Limited 1992

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