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Hypopharyngeal cancer associated with synchronous oesophageal cancer: risk factors and benefits of image-enhanced endoscopic screening

Published online by Cambridge University Press:  14 December 2017

X-G Ni ,
Q-Q Zhang ,
J-Q Zhu  and
G-Q Wang
X-G Ni*
Affiliation:
Department of Endoscopy, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China
Q-Q Zhang
Affiliation:
Department of Endoscopy, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China
J-Q Zhu
Affiliation:
Department of Endoscopy, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China
G-Q Wang
Affiliation:
Department of Endoscopy, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China
*
Address for correspondence: Dr Xiao-Guang Ni, Department of Endoscopy, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Panjiayuannanli, Chaoyang District, PO Box 2258, Beijing 100021, PR China Fax: +86 10 87711782 E-mail: nixiaoguang@126.com
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Abstract

Objectives:

To explore the risk factors associated with the occurrence of synchronous oesophageal cancer in patients with hypopharyngeal cancer, and to investigate the roles of image-enhanced endoscopic screening in the prediction and diagnosis of early oesophageal cancer.

Methods:

The clinical characteristics of patients with hypopharyngeal cancer (n = 160) were analysed. All patients underwent laryngoscopic and gastroscopic examination using image-enhanced endoscopic techniques before treatment.

Results:

Of 160 hypopharyngeal cancer patients, 43 (27 per cent) had synchronous oesophageal cancer. Heavy drinking (odds ratio = 4.787, p = 0.029) and local invasion of three or more anatomical sites (odds ratio = 14.391, p = 0.000) were independent risk factors for synchronous oesophageal cancer. Narrow-band imaging laryngoscopy could detect more invaded anatomical sites than ordinary white light endoscopy (t = 8.532, p = 0.000). More early oesophageal cancer cases were detected with Lugol chromoendoscopy than with non-Lugol iodine staining examination (χ2 = 4.925, p = 0.026).

Conclusion:

Synchronous oesophageal cancer is common in patients with hypopharyngeal cancer. The heavy drinking patients with hypopharyngeal cancer should undergo intensive monitoring. Image-enhanced endoscopic screening is helpful in the prediction and early detection of second primary oesophageal cancer.

Keywords

Hypopharyngeal CancerEsophageal CancerSecond Primary CancerEndoscopic ScreeningNarrow Band ImagingChromoendoscopy
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 132 , Issue 2 , February 2018 , pp. 154 - 161
Copyright
Copyright © JLO (1984) Limited 2017 

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References

1 Carvalho, AL, Nishimoto, IN, Califano, JA, Kowalski, LP. Trends in incidence and prognosis for head and neck cancer in the United States: a site-specific analysis of the SEER database. Int J Cancer 2005;114:806–16Google Scholar
2 Kuo, P, Chen, MM, Decker, RH, Yarbrough, WG, Judson, BL. Hypopharyngeal cancer incidence, treatment, and survival: temporal trends in the United States. Laryngoscope 2014;124:2064–9CrossRefGoogle ScholarPubMed
3 Hall, SF, Griffiths, R. Did the addition of concomitant chemotherapy to radiotherapy improve outcomes in hypopharyngeal cancer? A population-based study. Curr Oncol 2016;23:266–72Google Scholar
4 Lee, DH, Roh, JL, Baek, S, Jung, JH, Choi, SH, Nam, SY et al. Second cancer incidence, risk factor, and specific mortality in head and neck squamous cell carcinoma. Otolaryngol Head Neck Surg 2013;149:579–86Google Scholar
5 Lee, KD, Lu, CH, Chen, PT, Chan, CH, Lin, JT, Huang, CE et al. The incidence and risk of developing a second primary esophageal cancer in patients with oral and pharyngeal carcinoma: a population-based study in Taiwan over a 25 year period. BMC Cancer 2009;9:373 CrossRefGoogle Scholar
6 Jaiswal, G, Jaiswal, S, Kumar, R, Sharma, A. Field cancerization: concept and clinical implications in head and neck squamous cell carcinoma. J Exp Ther Oncol 2013;10:209–14Google ScholarPubMed
7 Huang, YC, Lee, YC, Tseng, PH, Chen, TC, Yang, TL, Lou, PJ et al. Regular screening of esophageal cancer for 248 newly diagnosed hypopharyngeal squamous cell carcinoma by unsedated transnasal esophagogastroduodenoscopy. Oral Oncol 2016;55:55–60 Google Scholar
8 Gong, EJ, Kim, DH, Ahn, JY, Choi, KS, Jung, KW, Lee, JH et al. Routine endoscopic screening for synchronous esophageal neoplasm in patients with head and neck squamous cell carcinoma: a prospective study. Dis Esophagus 2016;29:752–9Google Scholar
9 Heroiu Cataloiu, AD, Danciu, CE, Popescu, CR. Multiple cancers of the head and neck. Maedica (Buchar) 2013;8:80–5Google Scholar
10 Morris, LG, Sikora, AG, Patel, SG, Hayes, RB, Ganly, I. Second primary cancers after an index head and neck cancer: subsite-specific trends in the era of human papillomavirus-associated oropharyngeal cancer. J Clin Oncol 2011;29:739–46CrossRefGoogle ScholarPubMed
11 Wang, WL, Wang, CP, Wang, HP, Lee, CT, Chang, CY, Tai, CM et al. The benefit of pretreatment esophageal screening with image-enhanced endoscopy on the survival of patients with hypopharyngeal cancer. Oral Oncol 2013;49:808–13Google Scholar
12 Lim, H, Kim, DH, Jung, HY, Gong, EJ, Na, HK, Ahn, JY et al. Clinical significance of early detection of esophageal cancer in patients with head and neck cancer. Gut Liver 2015;9:159–65Google Scholar
13 Popescu, CR, Bertesteanu, SV, Mirea, D, Grigore, R, lonescu, D, Popescu, B. The epidemiology of hypopharynx and cervical esophagus cancer. J Med Life 2010;3:396–401 Google Scholar
14 Ni, XG, Wang, GQ. The role of narrow band imaging in head and neck cancers. Curr Oncol Rep 2016;18:10 Google Scholar
15 Hashimoto, CL, Iriya, K, Baba, ER, Navarro-Rodriguez, T, Zerbini, MC, Eisig, JN et al. Lugol's dye spray chromoendoscopy establishes early diagnosis of esophageal cancer in patients with primary head and neck cancer. Am J Gastroenterol 2005;100:275–82Google Scholar
16 Goda, K, Dobashi, A, Yoshimura, N, Kato, M, Aihara, H, Sumiyama, K et al. Narrow-band imaging magnifying endoscopy versus Lugol chromoendoscopy with pink-color sign assessment in the diagnosis of superficial esophageal squamous neoplasms: a randomised noninferiority trial. Gastroenterol Res Pract 2015;2015:639462 Google Scholar
17 Su, YY, Chen, WC, Chuang, HC, Guo, CS, Lin, YT, Luo, SD et al. Effect of routine esophageal screening in patients with head and neck cancer. JAMA Otolaryngol Head Neck Surg 2013;139:350–4CrossRefGoogle ScholarPubMed
18 Morimoto, M, Nishiyama, K, Nakamura, S, Suzuki, O, Kawaguchi, Y, Nakajima, A et al. Significance of endoscopic screening and endoscopic resection for esophageal cancer in patients with hypopharyngeal cancer. Jpn J Clin Oncol 2010;40:938–43CrossRefGoogle ScholarPubMed