The lead article for this issue of EJAM is Prof. Bernard J. Matkowsky's personalized survey-style article on the theory and application of singular perturbation methods to noisy dynamical systems in the limit of small noise. This article is based on his John von Neumann Prize lecture presented at the Society of Industrial and Applied Mathematics (SIAM) Annual Meeting in July 2017. The John von Neumann Lecture is awarded by SIAM for outstanding and distinguished contributions to the field of applied mathematical sciences and for the effective communication of these ideas to the community. From 1990–1996, Matkowsky was an inaugural editorial board member for EJAM.

Consider a deterministic dynamical system in a domain containing a stable equilibrium, e.g., a particle in a potential well. The particle, independent of initial conditions, eventually reaches the bottom of the well. If however, the particle is subjected to white noise, due, e.g., to collisions with a population of smaller, lighter particles comprising the medium through which the particle travels, a dramatic difference in the behaviour of the Brownian particle occurs. The particle will exit the well. The natural questions then are how long will it take for it to exit and from where on the boundary of the domain of attraction of the deterministic equilibrium (the rim of the well) will it exit. We compute the mean first passage time to the boundary and the mean probabilities of the exit positions. When the noise is small each quantity satisfies a singularly perturbed deterministic boundary value problem. We treat the problem by the method of matched asymptotic expansions (MAE) and generalizations thereof. MAE has been used successfully to solve problems in many applications. However, there exist problems for which MAE does not suffice. Among these are problems exhibiting boundary layer resonance, i.e., the problem of ‘spurious solutions’, which led some to conclude that this was ‘the failure of MAE’. We present a physical argument and four mathematical arguments to modify or augment MAE to make it successful. Finally, we discuss applications of the theory.

On the seventh line of the fifth page of the article the Backward Kolmogorov equation should read pt = Lp, and not ps = Lp.

The author apologises for the error.

We derive a class of Navier–Stokes–Cahn–Hilliard systems that models two-phase flows with mass transfer coupled to the process of chemotaxis. These thermodynamically consistent models can be seen as the natural Navier–Stokes analogues of earlier Cahn–Hilliard–Darcy models proposed for modelling tumour growth, and are derived based on a volume-averaged velocity, which yields simpler expressions compared to models derived based on a mass-averaged velocity. Then, we perform mathematical analysis on a simplified model variant with zero excess of total mass and equal densities. We establish the existence of global weak solutions in two and three dimensions for prescribed mass transfer terms. Under additional assumptions, we prove the global strong well-posedness in two dimensions with variable fluid viscosity and mobilities, which also includes a continuous dependence on initial data and mass transfer terms for the chemical potential and the order parameter in strong norms.

Adhesion between cells and other cells (cell–cell adhesion) or other tissue components (cell–matrix adhesion) is an intrinsically non-local phenomenon. Consequently, a number of recently developed mathematical models for cell adhesion have taken the form of non-local partial differential equations, where the non-local term arises inside a spatial derivative. The mathematical properties of such a non-local gradient term are not yet well understood. Here we use sophisticated estimation techniques to show local and global existence of classical solutions for such examples of adhesion-type models, and we provide a uniform upper bound for the solutions. Further, we discuss the significance of these results to applications in cell sorting and in cancer invasion and support the theoretical results through numerical simulations.

In 2008, the Defense Advanced Research Project Agency commissioned a database known as the Integrated Crisis Early Warning System to serve as the foundation for models capable of detecting and predicting increases in political conflict worldwide. Such models, by signalling expected increases in political conflict, would help inform and prepare policymakers to react accordingly to conflict proliferation both domestically and internationally. Using data from the Integrated Crisis Early Warning System, we construct and test a self-exciting point process, or Hawkes process, model to describe and predict amounts of domestic, political conflict; we focus on Colombia and Venezuela as examples for this model. By comparing the accuracy of fitted models to the observed data, we find that we are able to closely describe occurrences of conflict in each country. Thus, using this model can allow policymakers to anticipate relative increases in the amount of domestic political conflict following major events.

The Lippmann equation is considered as universal relationship between interfacial tension, double layer charge, and cell potential. Based on the framework of continuum thermo-electrodynamics, we provide some crucial new insights to this relation. For general interfaces such that the local curvature radius is large compared to the Debye length, we apply asymptotic analysis methods to obtain the Lippmann equation. We give precise definitions of the involved quantities and show that the interfacial tension of the Lippmann equation is composed of the surface tension of our general model, and contributions arising from the adjacent space charge layers that can only lower the interfacial tension. Moreover, it turns out that surface reactions can be consistently incorporated into the Lippmann equation, provided that there is no charge transfer from one side of the interface to the other. We apply the model to curved liquid metal electrodes and compare our model to experimental data of several mercury–electrolyte interfaces. We obtain qualitative and quantitative agreement in the 2 V potential range for various salt concentrations.