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Osteoclastic activity in chronic otitis media with cholesteatoma-related bone destruction

Published online by Cambridge University Press:  05 August 2021

A Özgür ,
T Yemiş ,
E Başbulut ,
N F Turgut ,
D Özdemir ,
G Akgül ,
D M Mehel  and
M Çelebi
A Özgür*
Affiliation:
İstanbul Yeni Yüzyıl University Gaziosmanpaşa Hospital, Department of Otorhinolaryngology, İstanbul, Turkey
T Yemiş
Affiliation:
Department of Otorhinolaryngology, Gümüşhane State Hospital, Gümüşhane/Turkey
E Başbulut
Affiliation:
Microbiology Laboratory, Samsun Education and Research Hospital, Samsun/Turkey
N F Turgut
Affiliation:
Department of Otorhinolaryngology, Samsun Health Practices and Research Centre, University of Health Sciences, Samsun, Turkey
D Özdemir
Affiliation:
Department of Otorhinolaryngology, Samsun Health Practices and Research Centre, University of Health Sciences, Samsun, Turkey
G Akgül
Affiliation:
Department of Otorhinolaryngology, Samsun Health Practices and Research Centre, University of Health Sciences, Samsun, Turkey
D M Mehel
Affiliation:
Department of Otorhinolaryngology, Samsun Health Practices and Research Centre, University of Health Sciences, Samsun, Turkey
M Çelebi
Affiliation:
Department of Otorhinolaryngology, Samsun Health Practices and Research Centre, University of Health Sciences, Samsun, Turkey
*
Author for correspondence: Dr Abdulkadir Özgür, İstanbul Yeni Yüzyıl University Gaziosmanpaşa Hospital Merkez Mah. Cukurcesme Caddesi No: 51 PB: 34245, Gaziosmanpaşa, İstanbul, Turkey E-mail: akozgur53@gmail.com
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Abstract

Background

Cholesteatoma-related bone destruction is the cause of many complications due to chronic otitis media. This study aimed to evaluate osteoclastic activity in cholesteatoma-related bone destruction using tartrate-resistant acid phosphatase 5b, an enzyme specific to osteoclastic activity.

Method

Seventy-two patients diagnosed with chronic otitis media were included in this study and were divided into two groups: with and without bone destruction. The blood serum and tissue tartrate-resistant acid phosphatase 5b levels from both groups were compared.

Results

There were no significant differences in the level of serum enzymes between both groups. However, in tissue samples, tartrate-resistant acid phosphatase 5b levels were significantly lower in the bone destruction group than the group without bone destruction.

Conclusion

This study determined that the level of tartrate-resistant acid phosphatase 5b, a specific enzyme for osteoclastic activity in cholesteatoma-related bone destruction, is locally decreased. This data suggests that osteoclastic activity may decrease in cholesteatoma-related bone destruction. However, further experimental and clinical studies are required to clarify this highly complex mechanism.

Keywords

CholesteatomaBone DestructionChronic Otitis Media
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 135 , Issue 10 , October 2021 , pp. 879 - 882
Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press

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Footnotes

Dr A Özgür takes responsibility for the integrity of the content of the paper

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