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Locating the scala media in the fixed human temporal bone for therapeutic access: a preliminary study

Published online by Cambridge University Press:  02 August 2006

H Pau ,
P Fagan  and
S Oleskevich
H Pau
Affiliation:
Ellison-Cliffe Fellowship, Royal Society of Medicine, London, UK Professorial Unit in Otology and Neurotology, St Vincent's Hospital, Sydney, NSW, Australia Stem Cell and Hearing Research, Neurobiology Program, Garvan Institute of Medical Research, Sydney, NSW, Australia
P Fagan
Affiliation:
Professorial Unit in Otology and Neurotology, St Vincent's Hospital, Sydney, NSW, Australia Stem Cell and Hearing Research, Neurobiology Program, Garvan Institute of Medical Research, Sydney, NSW, Australia
S Oleskevich
Affiliation:
Stem Cell and Hearing Research, Neurobiology Program, Garvan Institute of Medical Research, Sydney, NSW, Australia
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Abstract

Objective: To investigate the location of the scala media in relation to the round window niche in human temporal bones.

Design: Ten human temporal bones were investigated by radical mastoidectomy and promontory drill-out.

Setting: Temporal bone laboratory.

Outcome measures: The distance from the scala media to the anterior edge of the round window niche, measured by Fisch's stapedectomy measuring cylinders.

Results: The scala media was identified at the transection point of a vertical line 1.6 to 2.2 mm (mean=1.8 mm; standard deviation=0.2) anterior to the anterior edge of the round window niche and a horizontal line 0.2 mm inferior to the lower border of the oval window.

Conclusion: This report demonstrates the point of entry into the scala media via the promontory in fixed temporal bone models, which may provide a site of entry for stem cells and gene therapy insertion.

Keywords

Cochlear DuctStem CellGene Therapy
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 120 , Issue 11 , November 2006 , pp. 914 - 915
Copyright
2006 JLO (1984) Limited

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