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Microstructure and Dynamic Properties of Aggrecan Assemblies

Published online by Cambridge University Press:  10 January 2018

Ferenc Horkay ,
Peter J. Basser ,
Anne-Marie Hecht  and
Erik Geissler
Ferenc Horkay*
Affiliation:
Section on Quantitative Imaging and Tissue Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 13 South Drive, Bethesda, MD 20892-5772, USA
Peter J. Basser
Affiliation:
Section on Quantitative Imaging and Tissue Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 13 South Drive, Bethesda, MD 20892-5772, USA
Anne-Marie Hecht
Affiliation:
Université Grenoble Alpes, Laboratoire Interdisciplinaire de Physique, and CNRS, LIPhy, F-38402 St Martin d’Hères cedex, France.
Erik Geissler
Affiliation:
Université Grenoble Alpes, Laboratoire Interdisciplinaire de Physique, and CNRS, LIPhy, F-38402 St Martin d’Hères cedex, France.
*
*(Email: horkayf@helix.nih.gov)
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Abstract

The effect of ions on the structure and dynamics of aggracan solutions was investigated using a variety of scattering techniques (neutron spin echo, small angle neutron scattering, static and dynamic light scattering). The results show that aggrecan forms microgel-like assemblies which remain stable in the presence of counter-ions. As opposed to many synthetic polyelectrolytes which exhibit a great sensitivity to ion concentration and charge valency, it was found that aggrecan solutions are remarkable insensitive to charge valence. This property of aggrecan is consistent with its biological role as an ion reservoir mediating calcium metabolism and maintaining dimensional stability in cartilage and bone.

Keywords

biomimetic (assembly)neuron scatteringself-assembly
Type
Articles
Information
MRS Advances , Volume 3 , Issue 28: Biomaterials and Soft Materials , 2018 , pp. 1589 - 1595
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Copyright
Copyright © Materials Research Society 2018 

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