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Childhood obesity accelerates biological ageing: is oxidative stress a link?
Published online by Cambridge University Press: 13 May 2024
Abstract
Obesity is a multifactorial pathophysiological condition with an imbalance in biochemical, immunochemical, redox status and genetic parameters values. We aimed to estimate the connection between relative leucocyte telomere lengths (rLTL) – biomarker of cellular ageing with metabolic and redox status biomarkers values in a group of obese and lean children. The study includes 110 obese and 42 lean children and adolescents, both sexes. The results suggested that rLTL are significantly shorter in obese, compared with lean group (P < 0·01). Negative correlation of rLTL with total oxidant status (TOS) (Spearman’s ρ = –0·365, P < 0·001) as well as with C-reactive protein (Spearman’s ρ = –0·363, P < 0·001) were observed. Principal component analysis (PCA) extracted three distinct factors (i.e. principal components) entitled as: prooxidant factor with 35 % of total variability; antioxidant factor with 30 % of total variability and lipid antioxidant – biological ageing factor with 12 % of the total variability. The most important predictor of BMI > 30 kg/m2 according to logistic regression analysis was PCA-derived antioxidant factor’s score (OR: 1·66, 95th Cl 1·05–2·6, P = 0·029). PCA analysis confirmed that oxidative stress importance in biological ageing is caused by obesity and its multiple consequences related to prooxidants augmentation and antioxidants exhaustion and gave us clear signs of disturbed cellular homoeostasis deepness, even before any overt disease occurrence.
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- © The Author(s), 2024. Published by Cambridge University Press on behalf of The Nutrition Society
References
World Health Organization (2021) Obesity and Overweight. https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight (accessed July 2023).Google Scholar
Li, Y, Zhai, F, Yang, X, et al. (2007) Determinants of childhood overweight and obesity in China. Br J Nutr 97, 210–215.CrossRefGoogle ScholarPubMed
Halberg, N, Wernstedt-Asterholm, I & Scherer, PE (2008) The adipocyte as an endocrine cell. Endocrinol Metab Clin North Am 37, 753–768.CrossRefGoogle ScholarPubMed
Chudek, J & Wiecek, A (2006) Adipose tissue, inflammation and endothelial dysfunction. Pharmacol Rep 58, 81–88.Google ScholarPubMed
Paepegaey, A, Genser, L, Bouillot, J, et al. (2015) High Levels of CRP in morbid obesity: the central role of adipose tissue and lessons for clinical practice before and after bariatric surgery. Surg Obes Relat 11, 148–154.CrossRefGoogle ScholarPubMed
Cho, CH, Koh, YJ, Han, J, et al. (2007) Angiogenic role of LYVE-1-positive macrophages in adipose tissue. Circ Res (Epublication ahead of print version 1 February 2007).CrossRefGoogle Scholar
Heilbronn, LK & Campbell, LV (2008) Adipose tissue macrophages, low grade inflammation and insulin resistance in human obesity. Curr Pharm Des 14, 1225–1230.CrossRefGoogle ScholarPubMed
McMurray, F, Patten, D & Harper, ME (2016) Reactive oxygen species and oxidative stress in obesity-recent findings and empirical approaches. Obesity (Silver Spring) 24, 2301–2310.CrossRefGoogle ScholarPubMed
Halberg, N, Khan, T, Trujillo, ME, et al. (2009) HIF 1α induces fibrosis and insulin resistance in white adipose tissue. Mol Cell Biol 29, 4467–4483.CrossRefGoogle Scholar
Khoubai, F & Grosset, C (2021) DUSP9, a dual-specificity phosphatase with a key role in cell biology and human diseases. Int J Mol Sci 26, 11538.CrossRefGoogle Scholar
Azcona-Sanjulian, MC (2021) Telomere length and pediatric obesity: a review. Genes 12, 946.CrossRefGoogle ScholarPubMed
Kang, H (2021) Sample size determination and power analysis using the G * Power software. J Educ Eval Health Prof 30, 17.CrossRefGoogle Scholar
Erel, O (2004) A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clin Biochem 37, 277.CrossRefGoogle ScholarPubMed
Kotur-Stevuljević, J, Bogavac-Stanojević, N, Jelić-Ivanović, Z, et al. (2015) Oxidative stress and paraoxonase 1 status in acute ischemic stroke patients. Atherosclerosis 241, 192.CrossRefGoogle ScholarPubMed
Paripović, D, Kotur-Stevuljević, J, Vukašinović, A, et al. (2018) The influence of oxidative stress on cardiac remodeling in obese adolescents. Scand J Clin Lab Invest 78, 595–600.CrossRefGoogle ScholarPubMed
Kostić, K, Brborić, J, Delogum, G, et al. (2023) Antioxidant activity of natural phenols and derived hydroxylated biphenyls. Molecules 28, 2646.CrossRefGoogle ScholarPubMed
Erel, O (2005) A new automated colorimetric method for measuring total oxidant status. Clin Biochem 38, 1103.CrossRefGoogle ScholarPubMed
Conti, G, Caccamo, D, Siligato, R, et al. (2019) Association of higher advanced oxidation protein products (AOPPs) levels in patients with diabetic and hypertensive nephropathy. Medicina 10, 675.CrossRefGoogle Scholar
Bar-Or, D, Lau, E & Winkler, J (2000) A novel assay for cobalt-albumin binding and its potential as a marker for myocardial ischemia–a preliminary report1. J Emerg Med 19, 311–315.CrossRefGoogle Scholar
Alamdari, DH, Paletas, K, Pegiou, T, et al. (2007) A novel assay for the evaluation of the prooxidant-antioxidant balance, before and after antioxidant vitamin administration in type II diabetes patients. Clin Biochem 40, 248–254.CrossRefGoogle ScholarPubMed
Fuss, J, Kanof, E, Smith, D, et al. (2009) Isolation of whole mononuclear cells from peripheral blood and cord blood. Curr Protoc Immunol 7, 711–718.Google Scholar
Vukašinović, A, Klisic, A, Ostanek, B, et al. (2023) Redox status and telomere-telomerase system biomarkers in patients with acute myocardial infarction using a principal component analysis: is there a link? Int J Mol Sci 18, 14308.CrossRefGoogle Scholar
Bacha, F, Saad, R, Gungor, N, et al. (2006) Are obesity-related metabolic risk factors modulated by the degree of insulin resistance in adolescents? Diabetes Care 29, 1599–1604.CrossRefGoogle ScholarPubMed
Martinović, M, Belojević, G, Jakšić, M, et al. (2021) Cardiometabolic risk among montenegrin urban children in relation to obesity and gender. Acta Clin Croat 1, 3–9.Google Scholar
Tanti, JF, Ceppo, F, Jager, J, et al. (2013) Implication of inflammatory signaling pathways in obesity-induced insulin resistance. Front Endocrinol 3, 181.CrossRefGoogle ScholarPubMed
Fabbrini, E, Sullivan, S & Klein, S (2010) Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications. Hepatology 51, 679–689.CrossRefGoogle ScholarPubMed
Klisic, A, Kavaric, N, Ninic, A, et al. (2021) Oxidative stress and cardiometabolic biomarkers in patients with non-alcoholic fatty liver disease. Sci Rep 1, 18455.CrossRefGoogle Scholar
Hussain, S, Men, KK & Majid, NA (2017) Comparison of the clinical and biochemical profile of metabolic syndrome between obese children below and above 10 years old attending pediatric clinic hospital Universiti Sains Malaysia from 2006 to 2015. J Asean Fed Endocr Soc 32, 132–138.Google ScholarPubMed
Lingaraja, P & Srinivas, S (2018) Comparison of clinical and biochemical profile of obese and nonobese children. Int J Contemp Pediatr 6, 185.Google Scholar
Friedland, O, Nemet, D, Gorodnitsky, N, et al. (2002) Obesity and lipid profiles in children and adolescents. J Pediatr Endocrinol Metab 15, 1011–1016.CrossRefGoogle ScholarPubMed
Simmonds, M, Llewellyn, A, Owen, CG, et al. (2016) Predicting adult obesity from childhood obesity: a systematic review and meta-analysis. Obes Rev 17, 95–107.CrossRefGoogle ScholarPubMed
Brzeziński, M, Metelska, P, Myśliwiec, M, et al. (2020) Lipid disorders in children living with overweight and obesity- large cohort study from Poland. Lipids Health Dis 19, 47.CrossRefGoogle ScholarPubMed
Marseglia, L, Manti, S, D’Angelo, G, et al. (2014) Oxidative stress in obesity: a critical component in human diseases. Int J Mol Sci 16, 378–400.CrossRefGoogle ScholarPubMed
Li, S, Tan, HY, Wang, N, et al. (2015) The role of oxidative stress and antioxidants in liver diseases. Int J Mol Sci 16, 26087–26124.CrossRefGoogle ScholarPubMed
Ozata, M, Mergen, M, Oktenli, C, et al. (2002) Increased oxidative stress and hypozincemia in male obesity. Clin Biochem 35, 627–631.CrossRefGoogle ScholarPubMed
Horsandi, H, Nikpayam, O, Yousefi, R, et al. (2019) Zinc supplementation improves body weight management, inflammatory biomarkers and insulin resistance in individuals with obesity: a randomized, placebo-controlled, double-blind trial. Diabetol Metab Syndr 11, 101.CrossRefGoogle Scholar
Ogura, T, Matsuura, K, Matsumoto, Y, et al. (2004) Recent trends of hyperuricemia and obesity in Japanese male adolescents, 1991 through 2002. Metabolism 4, 448–453.CrossRefGoogle Scholar
Obeidat, A, Ahmad, N, Haddad, H, et al. (2016) Leptin and uric acid as predictors of metabolic syndrome in Jordanian adults. Nutr Res Pract 4, 411–417.CrossRefGoogle Scholar
Bedir, A, Topbas, M, Tanyeri, F, et al. (2003) Leptin might be a regulator of serum uric acid concentrations in humans. Jpn Heart J 4, 527–536.CrossRefGoogle Scholar
Jørgensen, RM, Bøttger, B, Vestergaard, ET, et al. (2022) Uric acid is elevated in children with obesity and decreases after weight loss. Front Pediatr 9, 814166.CrossRefGoogle ScholarPubMed
Giaccom, F & Brownlee, M (2010) Oxidative stress and diabetic complications. Circ Res 107, 1058–1070.CrossRefGoogle Scholar
Nikooyeh, B & Neyestani, TR (2016) Oxidative stress, type 2 diabetes and vitamin D: past, present and future. Diabetes Metab Res Rev 32, 260–267.CrossRefGoogle ScholarPubMed
Mengen, E, Uçaktürk, SA, Kocaay, P, et al. (2020) The significance of thiol/disulfide homeostasis and ischemia-modified albumin levels in assessing oxidative stress in obese children and adolescents. J Clin Res Pediatr Endocrinol 19, 45–54.CrossRefGoogle Scholar
Ucar, F, Sezer, S, Erdogan, S, et al. (2013) The relationship between oxidative stress and nonalcoholic fatty liver disease: its effects on the development of nonalcoholic steatohepatitis. Redox Rep 18, 127–133.CrossRefGoogle Scholar
Sun, L, Wang, Q, Liu, M, et al. (2020) Albumin binding function is a novel biomarker for early liver damage and disease progression in non-alcoholic fatty liver disease. Int J Mol Sci 69, 294–302.Google ScholarPubMed
Cristani, M, Speciale, A, Saija, A, et al. (2016) Circulating advanced Oxidation protein products as oxidative stress biomarkers and progression mediators in pathological conditions related to inflammation and immune dysregulation. Curr Med Chem 23, 3862–3882.CrossRefGoogle ScholarPubMed
Shammas, MA (2011) Telomeres, lifestyle, cancer, and aging. Curr Opin Clin Nutr Metab Care 14, 28–34.CrossRefGoogle ScholarPubMed
Barrett, JH, Iles, MM, Dunning, AM, et al. (2015) Telomere length and common disease: study design and analytical challenges. Hum Genet 134, 679–689.CrossRefGoogle ScholarPubMed
Wolkowitz, OM, Mellon, SH, Epel, ES, et al. (2011) Leukocyte telomere length in major depression: correlations with chronicity, inflammation and oxidative stress – preliminary findings. PLoS ONE 3, e17837.CrossRefGoogle Scholar
Buxton, L, Walters, G, Visvikis-Siest, S, et al. (2011) Childhood obesity is associated with shorter leukocyte telomere length. J Clin Endocrinol Metab 96, 1500–1505.CrossRefGoogle ScholarPubMed
Morell-Azanza, L, Ojeda-Rodríguez, A, Azcona-SanJulián, M, et al. (2020) Associations of telomere length with anthropometric and glucose changes after a lifestyle intervention in abdominal obese children. Nutr Metab Cardiovasc Dis 30, 694–700.CrossRefGoogle ScholarPubMed
Lansdorp, M (2022) Sex differences in telomere length, lifespan, and embryonic dyskerin levels. Aging Cell 21, 13614.CrossRefGoogle ScholarPubMed
Hin, YA (2019) How does obesity and physical activity affect aging? Focused on telomere as a biomarker of aging. J Obes Metab Syndr 28, 92–104.Google Scholar
Dejanović, VV, Stevuljević, JK, Vukašinović, A, et al. (2020) Oxidative stress and inflammatory markers PTX3, CypA, and HB-EGF: how are they linked in patients with STEMI? Angiology 71, 713–720.CrossRefGoogle ScholarPubMed
Tuğçe, D & Şima, Ş (2021) Measurement of paraoxonase and telomerase enzymes and HDL (high density lipoprotein) values and research of their possible relationships with each other in blood serum of obese cats. MAEU Vet Fak Derg 6, 104–108.Google Scholar
Subošić et al. supplementary material
Subošić et al. supplementary material
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