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Optical Interferometric Biosensor with PMMA as Functional Layer

Published online by Cambridge University Press:  01 February 2011

Wenhui Wang ,
Xiaodong Ma ,
Lisa-Jo Clarizia ,
Xingwei Wang  and
Melisenda McDonald
Wenhui Wang
Affiliation:
wenhui_wang@uml.edu, UMass Lowell, ECE, Lowell, Massachusetts, United States
Xiaodong Ma
Affiliation:
xiaodong_ma@student.uml.edu, UMass Lowell, ECE, Lowell, Massachusetts, United States
Lisa-Jo Clarizia
Affiliation:
LisaJo_Clarizia@uml.edu, UMass Lowell, Chemistry, Lowell, Massachusetts, United States
Xingwei Wang
Affiliation:
xingwei_wang@uml.edu, UMass Lowell, ECE, Lowell, Massachusetts, United States
Melisenda McDonald
Affiliation:
Melisenda_McDonald@uml.edu, UMass Lowell, Chemistry, Lowell, Massachusetts, United States
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Abstract

Silica-on-silicon label-free biosensor with PMMA (Poly(methyl methacrylate), as the functional layer was designed, fabricated, and tested. The sensor is based on Fabry Perot (FP) interferometry. Specific binding was tested with Human IgG and anti-Human IgG. Non-specific binding was tested with Human IgG and Mouse IgG. The testing results show that the sensor has a nearly six-fold greater response upon specific binding than upon non specific binding. Thermal and long term stability experiments show that the sensor is insensitive to the environment fluctuation. The fabrication process is simple without special surface treatment. In addition, this biosensor is inexpensive and easy to use.

Keywords

opticalsensorpolymer
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1133: Symposium AA – Materials for Optical Sensors in Biomedical Applications , 2008 , 1133-AA03-02
Copyright
Copyright © Materials Research Society 2009

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References

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