Sanderson (Canad. Math. Bull., 8 (1965), 505–513), considering a nonempty collection Σ of left ideals of a ring R, with unity, defined the concepts of “Σ-injective module” and “Σ-essential extension” for unital left modules. Letting Σ be an idempotent topologizing set (called a σ-set below) Σanderson proved the existence of a “Σ-injective hull” for any unital left module and constructed an Utumi Σ-quotient ring of R as the bicommutant of the Σ-injective hull of RR. In this paper, we extend the concepts of “Σinjective module”, “Σ-essentialextension”, and “Σ-injective hull” to modules over arbitrary rings. An overring Σ of a ring R is a Johnson (Utumi) left Σ-quotient ring of R if RR is Σ-essential (Σ-dense) in RS. The maximal Johnson and Utumi Σ-quotient rings of R are constructed similar to the original method of Johnson, and conditions are given to insure their equality. The maximal Utumi Σquotient ring U of R is shown to be the bicommutant of the Σ-injective hull of RR when R has unity. We also obtain a σ-set UΣ of left ideals of U, generated by Σ, and prove that Uis its own maximal Utumi UΣ-quotient ring. A Σ-singular left ideal ZΣ(R) of R is defined and U is shown to be UΣ-injective when Z Σ(R) = 0. The maximal Utumi Σ-quotient rings of matrix rings and direct products of rings are discussed, and the quotient rings of this paper are compared with these of Gabriel (Bull. Soc. Math. France, 90 (1962), 323–448) and Mewborn (Duke Math. J. 35 (1968), 575–580). Our results reduce to those of Johnson and Utumi when 1 ∊ R and Σ is taken to be the set of all left ideals of R.