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7 - Circadian Rhythm Disruption in Aging and Alzheimer’s Disease

Published online by Cambridge University Press:  07 October 2023

By
Marilyn J. Duncan
Edited by
Laura K. Fonken  and
Randy J. Nelson
Laura K. Fonken
Affiliation:
University of Texas, Austin
Randy J. Nelson
Affiliation:
West Virginia University
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Summary

Circadian rhythms exhibit many alterations during the normal aging process and more severe disruptions are evident in age-related neurological conditions such as Alzheimer’s disease (AD). Indeed, evidence suggests that circadian rhythm alterations increase susceptibility to AD and conversely that the progressive neuropathological features of AD such as amyloid-beta accumulation further exacerbate circadian rhythm disruption. Impairments in neural function in the master circadian pacemaker in the hypothalamic suprachiasmatic nucleus underlie age- and AD-related alterations in circadian rhythms. Deficits in expression of the clock genes constituting the molecular pathways controlling circadian rhythms also contribute to circadian rhythm impairments and neurodegeneration in senescence and AD. This chapter describes the mechanisms underlying age- and AD-related alterations in circadian rhythms as well as their possible causes and potential strategies for their amelioration.

Keywords

circadian clocksuprachiasmatic nucleusaged
Type
Chapter
Information
Biological Implications of Circadian Disruption
A Modern Health Challenge
 , pp. 165 - 182
Publisher: Cambridge University Press
Print publication year: 2023

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