Book contents
- Frontmatter
- Contents
- List of contributors
- Preface
- Part I Physiology and pathophysiology of nerve fibres
- Part II Pain
- Part III Control of central nervous system output
- 18 Synaptic transduction in neocortical neurones
- 19 Cortical circuits, synchronization and seizures
- 20 Physiologically induced changes of brain temperature and their effect on extracellular field potentials
- 21 Fusimotor control of the respiratory muscles
- 22 Cerebral accompaniments and functional significance of the long-latency stretch reflexes in human forearm muscles
- 23 The cerebellum and proprioceptive control of movement
- 24 Roles of the lateral nodulus and uvula of the cerebellum in cardiovascular control
- 25 Central actions of curare and gallamine: implications for reticular reflex myoclonus?
- 26 Pathophysiology of upper motoneurone disorders
- 27 Modulation of hypoglossal motoneurones by thyrotropin-releasing hormone and serotonin
- 28 Serotonin and central respiratory disorders in the newborn
- 29 Are medullary respiratory neurones multipurpose neurones?
- 30 Reflex control of expiratory motor output in dogs
- 31 Abnormal thoraco-abdominal movements in patients with chronic lung disease
- 32 Respiratory rhythms and apnoeas in the newborn
- 33 Cardiorespiratory interactions during apnoea
- 34 Impairment of respiratory control in neurological disease
- 35 The respiratory muscles in neurological disease
- Part IV Development, survival, regeneration and death
- Index
24 - Roles of the lateral nodulus and uvula of the cerebellum in cardiovascular control
from Part III - Control of central nervous system output
Published online by Cambridge University Press: 04 August 2010
- Frontmatter
- Contents
- List of contributors
- Preface
- Part I Physiology and pathophysiology of nerve fibres
- Part II Pain
- Part III Control of central nervous system output
- 18 Synaptic transduction in neocortical neurones
- 19 Cortical circuits, synchronization and seizures
- 20 Physiologically induced changes of brain temperature and their effect on extracellular field potentials
- 21 Fusimotor control of the respiratory muscles
- 22 Cerebral accompaniments and functional significance of the long-latency stretch reflexes in human forearm muscles
- 23 The cerebellum and proprioceptive control of movement
- 24 Roles of the lateral nodulus and uvula of the cerebellum in cardiovascular control
- 25 Central actions of curare and gallamine: implications for reticular reflex myoclonus?
- 26 Pathophysiology of upper motoneurone disorders
- 27 Modulation of hypoglossal motoneurones by thyrotropin-releasing hormone and serotonin
- 28 Serotonin and central respiratory disorders in the newborn
- 29 Are medullary respiratory neurones multipurpose neurones?
- 30 Reflex control of expiratory motor output in dogs
- 31 Abnormal thoraco-abdominal movements in patients with chronic lung disease
- 32 Respiratory rhythms and apnoeas in the newborn
- 33 Cardiorespiratory interactions during apnoea
- 34 Impairment of respiratory control in neurological disease
- 35 The respiratory muscles in neurological disease
- Part IV Development, survival, regeneration and death
- Index
Summary
The cerebellum is involved in the control of not only motor but also autonomic functions (Moruzzi, 1950; Ito, 1984). Blood pressure, heart rate and respiration have been shown to be affected by electrical stimulation of the anterior vermis and the fastigial nucleus (Moruzzi, 1950; Ban, Hilliard & Sawyer, 1960; Achari & Downman, 1970; Nisimaru & Kawaguchi, 1984). Previously, we reported that electrical stimulation of localized regions in the posterior lobe (lobules VII, VIII and X) produced inhibition of renal sympathetic nerve activity and a fall in blood pressure in anaesthetized rabbits (Nisimaru, Yamamoto & Shimoyama, 1984b; Nisimaru & Watanabe, 1985). More recently, Bradley et al., (1987a, b) also reported that electrical stimulation of the medial uvula (lobule IXb) induced cardiovascular responses in rabbits and cats. Interestingly, they showed that the effect of stimulation of the medial uvula was reversed when the anaesthesia wore off in decerebrate rabbits. However, little attention has been paid to the involvement of the lateral portion of the nodulus–uvula in cardiovascular function, on which I shall focus in this chapter. As an index of cardiovascular effects of cerebellar stimulation, we recorded, integrated and averaged efferent discharges from renal sympathetic nerves, which were affected by cerebellar stimulations with trains of only a few pulses. For stimulus mapping, a platinum–iridium needle electrode (diameter 200 μm, excluding the layer of insulation) was inserted into the cerebellum.
Stimulation of the lateral nodulus–uvula in anaesthetized rabbits.
In rabbits anaesthetized with α-chloralose plus urethane (30 and 600 mg/kg), lateral parts of the dorsal nodulus and the most ventral uvula were stimulated with a train of ten brief current pulses no stronger than 100 μA (200 Hz).
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- The Neurobiology of DiseaseContributions from Neuroscience to Clinical Neurology, pp. 257 - 265Publisher: Cambridge University PressPrint publication year: 1996
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