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Case 62 - Inclusion Body Myositis (IBM)

from Myopathies

Published online by Cambridge University Press:  aN Invalid Date NaN

Jessica E. Hoogendijk
Affiliation:
University Medical Center Utrecht
Marianne de Visser
Affiliation:
Amsterdam University Medical Center
Pieter A. van Doorn
Affiliation:
Erasmus MC, University Medical Center, Rotterdam
Erik H. Niks
Affiliation:
Leiden University Medical Center
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Summary

A 64-year-old man suffered from progressive swallowing difficulty, in particular of solid food. There was a feeling of food getting stuck. He needed to take small bites and coughed while he was eating. Choking occurred frequently, and sometimes food came out his nose. He lost 7 kg over the past year. Gradually, drinking also became difficult. His GP first referred him to an ENT specialist and subsequently to a gastroenterologist who referred him to a neuromuscular centre. He was treated with Botox injections in the cricopharyngeal muscle, and this ameliorated his swallowing problems for about a year. He did not complain about limb weakness, diplopia, drooping eyelids, slurring of speech, shortness of breath, or muscle twitching. Family history was unremarkable.

Type
Chapter
Information
Neuromuscular Disease
A Case-Based Approach
, pp. 256 - 259
Publisher: Cambridge University Press
Print publication year: 2024

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References

Suggested Reading

Cox, FM, Titulaer, MJ, Sont, JK, et al. A 12-year follow-up in sporadic inclusion body myositis: an end stage with major disabilities. Brain 2011;134:31673175.CrossRefGoogle ScholarPubMed
Greenberg, SA. Inclusion body myositis: clinical features and pathogenesis. Nat Rev Rheumatol 2019;15(5):257272.CrossRefGoogle ScholarPubMed
Lilleker, JB, Naddaf E, Saris CGJ, Schmidt J, de Visser M, Weihl CC; 272nd ENMC workshop participants. 272nd ENMC international workshop: 10 Years of progress - revision of the ENMC 2013 diagnostic criteria for inclusion body myositis and clinical trial readiness. 16-18 June 2023, Hoofddorp, The Netherlands. Neuromuscul Disord. 2024 Apr;37:36-51. doi: 10.1016/j.nmd.2024.03.001. Epub 2024 Mar 7. PMID: 38522330.CrossRefGoogle ScholarPubMed
Shelly, S, Mielke, MM, Mandrekar, J, et al. Epidemiology and natural history of inclusion body myositis: a 40-year population-based study. Neurology 2021;96(21):e2653e2661.CrossRefGoogle ScholarPubMed

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