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Chapter 10 - Tubulointerstitial Diseases with Crystal and Pigment Deposits

from Section 3 - Tubulointerstitial Diseases

Published online by Cambridge University Press:  10 August 2023

By
Joris J. Roelofs  and
Tri Q. Nguyen
Edited by
Helen Liapis
Helen Liapis
Affiliation:
Ludwig Maximilian University, Nephrology Center, Munich, Adjunct Professor and Washington University St Louis, Department of Pathology and Immunology, Retired Professor
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Summary

Tubulointerstitial diseases with crystal and pigment deposits are important histopathological disease entities that occur in pediatric patients and that are associated with acute and chronic kidney injury. Tubulointerstitial diseases with crystal deposits include oxalate nephropathy, nephrocalcinosis and 2,8-dihydroxyadenine (DHA) nephropathy. Tubulointerstitial diseases with pigment deposits include myoglobin cast nephropathy, hemoglobin cast nephropathy, red blood cell casts and bile cast nephropathy.

Although some of these tubulointerstitial diseases may show overlapping histopathological features, it is important to distinguish them as separate entities, since each of them is associated with distinct clinical symptoms, etiologies, therapies and prognosis.

Keywords

Oxalate nephropathynephrocalcinosisadenine phosphoribosyltransferase deficiencyDHA nephropathymyoglobin cast nephropathyhemoglobin cast nephropathyred blood cell castsbile cast nephropathypigment nephropathy
Type
Chapter
Information
Pediatric Nephropathology & Childhood Kidney Tumors , pp. 197 - 212
Publisher: Cambridge University Press
Print publication year: 2023

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References

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