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Chapter 3 - Red Blood Cell Life Span, Senescence, and Destruction

from Section 1 - The Normal Human Red Blood Cell

Published online by Cambridge University Press:  18 April 2018

Edward J. Benz, Jr.
Affiliation:
Dana Farber Cancer Institute
Nancy Berliner
Affiliation:
Brigham and Women's Hospital, Boston
Fred J. Schiffman
Affiliation:
Children's Hospital, Boston
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Summary

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Type
Chapter
Information
Anemia
Pathophysiology, Diagnosis, and Management
, pp. 19 - 22
Publisher: Cambridge University Press
Print publication year: 2017

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References

Ney, PA. Normal and disordered reticulocyte maturation. Curr Opin Hematol. 2011; 18(3):152157.Google Scholar
Bosman, GJCGM, Werre, JM, Willekens, FLA, Novotný, VMJ. Erythrocyte ageing in vivo and in vitro: structural aspects and implications for transfusion. Transfus Med. 2008; 18(6):335347.Google Scholar
Gifford, SC, Derganc, J, Shevkoplyas, SS, Yoshida, T, Bitensky, MW. A detailed study of time-dependent changes in human red blood cells: from reticulocyte maturation to erythrocyte senescence. Br J Haematol. 2006; 135(3):395404.CrossRefGoogle ScholarPubMed
Liu, J, Guo, X, Mohandas, N, Chasis, JA, An, X. Membrane remodeling during reticulocyte maturation. Blood. 2010; 115(10):20212027.Google Scholar
Liu, J, Mohandas, N, An, X. Membrane assembly during erythropoiesis. Curr Opin Hematol. 2011; 18(3):133138.CrossRefGoogle ScholarPubMed
Schrier, SL. What does the spleen see? Blood. 2012; 120(2):242243.Google Scholar
Ashby, W. The determination of the length of life of transfused blood corpuscles in man. J Exp Med. 1919; 29(3):267281.CrossRefGoogle ScholarPubMed
Franco, RS. Measurement of red cell life span and aging. Transfus Med Hemother. 2012; 39(5):302307.Google Scholar
Bratosin, D, Mazurier, J, Tissier, JP, et al. Cellular and molecular mechanisms of senescent erythrocyte phagocytosis by macrophages. A review. Biochimie. 1998; 80(2):173195.CrossRefGoogle ScholarPubMed
Willekens, FLA, Werre, JM, Groenen-Döpp, YAM, Roerdinkholder-Stoelwinder, B, de Pauw, B, Bosman, GJCGM. Erythrocyte vesiculation: a self-protective mechanism? Br J Haematol. 2008; 141(4):549556.CrossRefGoogle ScholarPubMed
Low, PS, Waugh, SM, Zinke, K, Drenckhahn, D. The role of hemoglobin denaturation and band 3 clustering in red blood cell aging. Science. 1985; 227(4686):531533.CrossRefGoogle ScholarPubMed
Lutz, HU. Naturally occurring anti-band 3 antibodies in clearance of senescent and oxidatively stressed human red blood cells. Transfus Med Hemother. 2012; 39(5):321327.Google Scholar
Kay, M. Immunoregulation of cellular life span. Ann N Y Acad Sci. 2005; 1057(1):85111.CrossRefGoogle ScholarPubMed
Kay, MM. Isolation of the phagocytosis-inducing IgG-binding antigen on senescent somatic cells. Nature. 1981; 289(5797):491494.Google Scholar
Christian, JA, Rebar, AH, Boon, GD, Low, PS. Senescence of canine biotinylated erythrocytes: increased autologous immunoglobulin binding occurs on erythrocytes aged in vivo for 104 to 110 days. Blood. 1993; 82(11):34693473.Google Scholar
Freikman, I, Fibach, E. Distribution and shedding of the membrane phosphatidylserine during maturation and aging of erythroid cells. BBA – Biomembranes. 2011; 1808(12):27732780.Google Scholar
Schroit, AJ, Madsen, JW, Tanaka, Y. In vivo recognition and clearance of red blood cells containing phosphatidylserine in their plasma membranes. J Biol Chem. 1985; 260(8):51315138.Google Scholar
Lee, SJ, Park, SY, Jung, MY, Bae, SM, Kim, IS. Mechanism for phosphatidylserine-dependent erythrophagocytosis in mouse liver. Blood. 2011; 117(19):52155223.CrossRefGoogle ScholarPubMed
Boas, FE, Forman, L, Beutler, E. Phosphatidylserine exposure and red cell viability in red cell aging and in hemolytic anemia. Proc Natl Acad Sci USA. 1998; 95(6):30773081.Google Scholar
Oldenborg, PA. CD47: a cell surface glycoprotein which regulates multiple functions of hematopoietic cells in health and disease. ISRN Hematol. 2013; 2013(5):119.Google Scholar
Olsson, M, Oldenborg, PA. CD47 on experimentally senescent murine RBCs inhibits phagocytosis following Fc receptor-mediated but not scavenger receptor-mediated recognition by macrophages. Blood. 2008; 112(10):42594267.CrossRefGoogle Scholar
Burger, P, Hilarius-Stokman, P, de Korte, D, van den Berg, TK, van Bruggen, R. CD47 functions as a molecular switch for erythrocyte phagocytosis. Blood. 2012; 119(23):55125521.Google Scholar
Burger, P, De Korte, D, van den Berg, TK, van Bruggen, R. CD47 in erythrocyte ageing and clearance – the Dutch point of view. Transfus Med Hemother. 2012; 39(5):348352.Google Scholar
Mebius, RE, Kraal, G. Structure and function of the spleen. Nat Rev Immunol. 2005; 5(8):606616.Google Scholar
Safeukui, I, Buffet, PA, Deplaine, G, et al. Quantitative assessment of sensing and sequestration of spherocytic erythrocytes by the human spleen. Blood. 2012; 120(2):424430.Google Scholar

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