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18 - Cell Death in the Olfactory System

from Part II - Cell Death in Tissues and Organs

Published online by Cambridge University Press:  07 September 2011

Douglas R. Green
By
Pawel Kermer
Edited by
John C. Reed
Douglas R. Green
Affiliation:
St. Jude Children's Research Hospital, Memphis, Tennessee
Pawel Kermer
Affiliation:
DFG Research Center “Molecular Physiology of the Brain” (CMPB), Germany
John C. Reed
Affiliation:
Sanford-Burnham Medical Research Institute, La Jolla, California
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Summary

Introduction

The olfactory system is one of the most plastic regions in the brain, where neurons are continuously replaced and neuronal circuits are modulated throughout life. Although there is a constant replacement of receptor neurons in the adult olfactory epithelium, there is a perpetual integration of new neurons into the adult olfactory bulb. Hence a fine-tuned program to balance neuronal apoptosis and survival is necessary. This chapter summarizes current knowledge about life and death in the adult olfactory epithelium and olfactory bulb after illustrating normal olfactory anatomy. Finally, olfactory neuronal death is revisited in the context of neurodegenerative diseases.

Type
Chapter
Information
Apoptosis
Physiology and Pathology
 , pp. 194 - 200
Publisher: Cambridge University Press
Print publication year: 2011

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