Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Hostname: page-component-848d4c4894-pftt2 Total loading time: 0 Render date: 2024-06-07T11:06:01.426Z Has data issue: false hasContentIssue false

Chapter 15 - Acute Myeloid Leukemia and Related Precursor Neoplasms

from Section IV - Precursor Hematopoietic Neoplasms and Related Neoplasms

Published online by Cambridge University Press:  25 November 2023

By
Virginia Knez ,
Xiayuan Liang ,
Billie Carstens  and
Silvia T Bunting
Edited by
Silvia Tse Bunting ,
Xiayuan Liang ,
Michele E. Paessler  and
Satheesh Chonat
Silvia Tse Bunting
Affiliation:
Cleveland Clinic Florida Weston
Xiayuan Liang
Affiliation:
University of Colorado
Michele E. Paessler
Affiliation:
University of Pennsylvania School of Medicine
Satheesh Chonat
Affiliation:
Emory University, Atlanta
Get access

Summary

Acute myeloid leukemia (AML) is a heterogeneous group of diseases representing a clonal expansion of immature, non-lymphoid, bone marrow-derived cells that involve the bone marrow, blood, and extramedullary tissues. In general, blood or bone marrow blast counts ≥ 20% () are required for diagnosing AML, except for AML with t (8;21) (q22; q22.1), AML with inv (16) (p13.1q22) or t (16;16) (p13.1; q22), and acute promyelocytic leukemia (APML) with PML-RARA [1–4]. The World Health Organization (WHO) classification incorporates morphologic, immunophenotypic, genetic, and clinical features to define prognostically significant disease [3–5].

Type
Chapter
Information
Atlas of Pediatric Hematopathology , pp. 147 - 175
Publisher: Cambridge University Press
Print publication year: 2023

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Arber, DA, Brunning, RD, Le Beau, MM, Falini, B, Vardiman, JW, Porwit, A, et al. Acute myeloid leukemia with recurrent genetic abnormalities. In Swerdlow, SH, Campo, E, Harris, NL, et al., eds. WHO classification of tumours of haematopoietic and lymphoid tissues. Revised 4th ed. Lyon: IARC Press; 2017:130–49.Google Scholar
Arber, DA, Brunning, RD, Orazi, A, Porwit, A, Peterson, LC, Thiele, J, et al. Acute myeloid leukemia, NOS. In Swerdlow, SH, Campo, E, Harris, NL, et al., eds. WHO classification of tumours of haematopoietic and lymphoid tissues. Revised 4th ed. Lyon: IARC Press; 2017:156–66.Google Scholar
Arber, DA, Brunning, RD, Orazi, A, Bain, BJ, Porwit, A, Le Beau, MM, Greenberg, PL. Acute myeloid leukemia with myelodysplasia-related changes. In Swerdlow, SH, Campo, E, Harris, NL, et al., eds. WHO classification of tumours of haematopoietic and lymphoid tissues. Revised 4th ed. Lyon: IARC Press; 2017:150–2.Google Scholar
Vardiman, JW, Arber, DA, Brunning, RD, Larson, RA, Matutes, E, Baumann, I, Kvasnicka, HM. Therapy-related myeloid neoplasms. In Swerdlow, SH, Campo, E, Harris, NL, et al., eds. WHO classification of tumours of haematopoietic and lymphoid tissues. Revised 4th ed. Lyon: IARC Press; 2017:153–5.Google Scholar
Pileri, SA, Orazi, A, Falini, B. Myeloid sarcoma. In Swerdlow, SH, Campo, E, Harris, NL, et al., eds. WHO classification of tumours of haematopoietic and lymphoid tissues. Revised 4th ed.Lyon: IARC Press; 2017:167–8.Google Scholar
Matynia, AP, Szankasi, P, Shen, W, Kelley, TW. Molecular genetic biomarkers in myeloid malignancies. Arch Pathol Lab Med. 2015 May; 139(5): 594–601.CrossRefGoogle ScholarPubMed
Greenberg, PL, Stone, RM, Bejar, R, Bennett, JM, Bloomfield, CD, Borate, U, et al. Myelodysplastic syndromes, version 2.2015. J Natl Compr Canc Netw. 2015 Mar 1; 13(3): 261–72.CrossRefGoogle ScholarPubMed
Wang, SA. Myelodysplastic syndromes and therapy-related myeloid neoplasms. In Proytcheva, MA, ed. Diagnostic pediatric hematopathology. Cambridge: Cambridge University Press; 2011:253–71.Google Scholar
Coenen, EA, Zwaan, CM, Reinhardt, D, Harrison, CJ, Haas, OA, de Haas, V, et al. Pediatric acute myeloid leukemia with t (8; 16) (p11; p13), a distinct clinical and biological entity: A collaborative study by the International-Berlin-Frankfurt-Münster AML-study group. Blood. 2013 Oct 10;122(15): 2704–13.CrossRefGoogle Scholar
Borowitz, MJ, Bene, MC, Harris, NL, Porwit, A, Matutes, E, Arber, DA. Acute leukemias of ambiguous lineage. In Swerdlow, SH, Campo, E, Harris, NL, et al., eds. WHO classification of tumours of haematopoietic and lymphoid tissues. Revised 4th ed. Lyon: IARC Press; 2017:180–7.Google Scholar
Döhner, H, Estey, E, Grimwade, D, Amadori, S, Appelbaum, FR, Büchner, T, et al. Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel. Blood. 2017 Jan 26; 129(4): 424–47.CrossRefGoogle ScholarPubMed
Alexander, TB, Gu, Z, Iacobucci, I, Dickerson, K, Choi, JK, Xu, B, et al. The genetic basis and cell of origin of mixed phenotype acute leukaemia. Nature. 2018 Oct; 562(7727): 373–9.CrossRefGoogle ScholarPubMed

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×