Book contents
- Frontmatter
- CONTENTS
- Acknowledgements
- List of Contributors
- List of Figures
- Biologics: An Introduction
- Part I Producing Nature
- Part II The Body Politics of Biologics
- Part III The Making of Contested Biologics
- Commentary: Biologics, Medicine and the Therapeutic Revolution: Towards Understanding the History of Twentieth-Century Medicine
- Notes
- Index
Biologics: An Introduction
- Frontmatter
- CONTENTS
- Acknowledgements
- List of Contributors
- List of Figures
- Biologics: An Introduction
- Part I Producing Nature
- Part II The Body Politics of Biologics
- Part III The Making of Contested Biologics
- Commentary: Biologics, Medicine and the Therapeutic Revolution: Towards Understanding the History of Twentieth-Century Medicine
- Notes
- Index
Summary
Over the past century, our bodies have increasingly become exposed to the pharmaceutical action of incorporated biological substances. Some of these have become so ubiquitous that we have even stopped thinking about them as ‘biologics’. We swallow our daily vitamin pills; we rely on vaccines and antibiotics when microbes proliferate; we account for the adverse effects of cortisone; we live a more-or-less normal life thanks to regular injections of insulin or an organ transplant; and we place our faith in monoclonal antibodies when a tumour has been diagnosed. One recent textbook definition of biologics provides us with still more examples:
By definition biologics are proteins and/or derivatives thereof that modulate the immune system, down regulate the inflammatory response or support tumor specific defence. Biologics – also known as ‘biologicals’ or ‘recombinant therapeutics’ – do not represent one homogeneous group of drugs. Monoclonal antibodies, fusion proteins (along with other proteins, toxins and radionucleotides) and recombinant proteins, growth factors, anti- and pro-angiogenic factors, and expression vectors generating proteins in situ may all be included as members of this class of pharmaceuticals.
This recent definition does not include vitamins, hormones, antibiotics or vaccines, although they have been and sometimes still are categorized as ‘biologics’ or ‘biologicals’.
The term ‘biologics’ first emerged in connection with national health-care legislation and the control of vaccine production in the US more than a hundred years ago.
- Type
- Chapter
- Information
- Publisher: Pickering & ChattoFirst published in: 2014