Skip to main content Accessibility help
×
Hostname: page-component-77c89778f8-vsgnj Total loading time: 0 Render date: 2024-07-19T11:20:21.956Z Has data issue: false hasContentIssue false

21 - Pathobiology of graft-versus-host disease

Published online by Cambridge University Press:  31 July 2009

Reinhold Munker
Affiliation:
Louisiana State University
Hillard M. Lazarus
Affiliation:
University Hospitals Case Medical Center
Kerry Atkinson
Affiliation:
University of Queensland
Get access
Type
Chapter
Information
The BMT Data Book , pp. 313 - 330
Publisher: Cambridge University Press
Print publication year: 2009

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Anasetti, C, Amos, D, PG, Beatty, et al. 1989. Effect of HLA compatibility on engraftment of bone marrow transplants in patients with leukemia or lymphoma. N Engl J Med 320(4): 197–204.CrossRefGoogle ScholarPubMed
BE, Anderson, J, Mcniff, J, Yan, et al. 2003. Memory CD4+ T cells do not induce graft-versus-host disease. J Clin Invest 112(1): 101–08.Google Scholar
JH, Antin, JL, Ferrara. 1992. Cytokine dysregulation and acute graft-versus-host disease. Blood 80(12): 2964–68.Google Scholar
F, Aosai, C, Ohlen, HG, Ljunggren, et al. 1991. Different types of allospecific CTL clones identified by their ability to recognize peptide loading-defective target cells. Eur J Immunol 21(11): 2767–74.Google Scholar
FR, Appelbaum. Haematopoietic cell transplantation as immunotherapy. 2001. Nature 411(6835): 385–89.Google Scholar
T, Banovic, KP, Macdonald, ES, Morris, et al. 2005. TGF-beta in allogeneic stem cell transplantation: friend or foe?Blood 106(6): 2206–14.Google Scholar
JN, Barker, JE, Wagner. 2003. Umbilical-cord blood transplantation for the treatment of cancer. Nat Rev Cancer 3(7): 526–32.Google Scholar
JN, Barker, DJ, Weisdorf, TE, Defor, et al. 2005. Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy. Blood 105(3): 1343–47.Google Scholar
RE, Billingham. 1966. The biology of graft-versus-host reactions. Harvey Lec. 62: 21–78.Google Scholar
M, Bleakley, SR, Riddell. 2004. Molecules and mechanisms of the graft-versus-leukaemia effect. Nat Rev Cancer 4(5): 371–80.Google Scholar
C, Bonini, G, Ferrari, S, Verzeletti, P, Servida, E, Zappone. 1997. HSV-TK Gene Transfer into Donor Lymphocytes for Control of Allogeneic Graft-Versus-Leukemia. Science 276: 1719–24.Google Scholar
GR, Brown, E, Lee, DL, Thiele. 2002. TNF-TNFR2 interactions are critical for the development of intestinal graft-versus-host disease in MHC class II-disparate (C57BL/6J – –>C57BL/6J x bm12)F1 mice. J Immunol 168(6): 3065–71.Google Scholar
J, Cavet, AM, Dickinson, J, Norden, PR, Taylor, GH, Jackson, PG, Middleton. 2001. Interferon-gamma and interleukin-6 gene polymorphisms associate with graft-versus-host disease in HLA-matched sibling bone marrow transplantation. Blood 98(5): 1594–600.Google Scholar
J, Cavet, PG, Middleton, M, Segall, H, Noreen, SM, Davies, AM, Dickinson. 1999. Recipient tumor necrosis factor-alpha and interleukin-10 gene polymorphisms associate with early mortality and acute graft-versus-host disease severity in HLA-matched sibling bone marrow transplants. Blood 94(11): 3941–46.Google Scholar
BJ, Chen, X, Cui, C, Liu, NJ, Chao. 2002. Prevention of graft-versus-host disease while preserving graft-versus-leukemia effect after selective depletion of host-reactive T cells by photodynamic cell purging process. Blood 99(9): 3083–38.Google Scholar
BJ, Chen, X, Cui, GD, Sempowski, C, Liu, NJ, Chao. 2004. Transfer of allogeneic CD62L- memory T cells without graft-versus-host disease. Blood 103(4): 1534–41.Google Scholar
EY, Choi, GJ, Christianson, Y, Yoshimura, et al. 2002a. Real-time T-cell profiling identifies H60 as a major minor histocompatibility antigen in murine graft-versus-host disease. Blood 100(13): 4259–65.Google Scholar
EY, Choi, GJ, Christianson, Y, Yoshimura, et al. 2002b. Immunodominance of H60 is caused by an abnormally high precursor T cell pool directed against its unique minor histocompatibility antigen peptide. Immunity 17(5): 593–603.Google Scholar
JL, Cohen, O, Boyer. 2006. The role of CD4(+)CD25(hi) regulatory T cells in the physiopathogeny of graft-versus-host disease. Curr Opin Immunol 18: 580–5.Google Scholar
KL, Csencsits, DK, Bishop. 2003. Contrasting alloreactive CD4+ and CD8+ T cells: there's more to it than MHC restriction. Am J Transplant 3(2): 107–15.Google Scholar
SM, Davies, L, Ruggieri, T, DeFor, et al. 2002. Evaluation of KIR ligand incompatibility in mismatched unrelated donor hematopoietic transplants. Killer immunoglobulin-like receptor. Blood 100(10): 3825–27.Google Scholar
M, Bueger, A, Bakker, H, Bontkes, JJ, Rood, E, Goulmy. 1993. High frequencies of cytotoxic T cell precursors against minor histocompatibility antigens after HLA-identical BMT: absence of correlation with GVHD. Bone Marrow Transplant 11: 363–68.Google Scholar
M, Bueger, A, Bakker, JJ, Rood, F, Woude, E, Goulmy. 1992. Tissue distribution of human minor histocompatibility antigens. Ubiquitous versus restricted tissue distribution indicates heterogeneity among human cytotoxic T lymphocyte-defined non-MHC antigens. J Immunol 149(5): 1788–94.Google Scholar
M, Bueger, E, Goulmy. 1993. Human minor histocompatibility antigens. Transpl Immunol 1(1): 28–38.Google Scholar
HJ, Deeg. 2007. How I treat refractory acute GVHD. Blood.Google Scholar
JM, Haan, NE, Sherman, E, Blokland, et al. 1995. Identification of a graft versus host disease-associated human minor histocompatibility antigen. Science 268: 1476–1480.Google Scholar
AM, Dickinson, D, Charron. 2005. Non-HLA immunogenetics in hematopoietic stem cell transplantation. Curr Opin Immunol 17(5): 517–25.Google Scholar
AM, Dickinson, XN, Wang, L, Sviland, et al. 2002. In situ dissection of the graft-versus-host activities of cytotoxic T cells specific for minor histocompatibility antigens. Nat Med 8(4): 410–14.Google Scholar
UA, Duffner, Y, Maeda, KR, Cooke, et al. 2004. Host dendritic cells alone are sufficient to initiate acute graft-versus-host disease. J Immunol 172(12): 7393–98.Google Scholar
ML, Dustin. 2001. Role of adhesion molecules in activation signaling in T lymphocytes. J Clin Immunol 21(4): 258–63.Google Scholar
JLM, Ferrara, HJ, Deeg. 1991. Graft versus host disease. N. Engl. J. Med. 324: 667–674.Google Scholar
JL, Ferrara, P, Reddy. 2006. Pathophysiology of graft-versus-host disease. Semin Hematol 43(1): 3–10.Google Scholar
N, Flomenberg, LA, Baxter-Lowe, D, Confer, et al. 2004. Impact of HLA class I and class II high-resolution matching on outcomes of unrelated donor bone marrow transplantation: HLA-C mismatching is associated with a strong adverse effect on transplantation outcome. Blood 104(7): 1923–30.Google Scholar
P, Fontaine, G, Roy-Proulx, L, Knafo, C, Baron, DC, Roy, C, Perreault. 2001. Adoptive transfer of minor histocompatibility antigen-specific T lymphocytes eradicates leukemia cells without causing graft-versus-host disease. Nat Med 7(7): 789–94.Google Scholar
DH, Fowler, K, Kurasawa, R, Smith, MA, Eckhaus, RE, Gress. 1994. Donor CD4-enriched cells of Th2 cytokine phenotype regulate graft-versus-host disease without impairing allogeneic engraftment in sublethally irradiated mice. Blood 84: 3540.Google Scholar
E, Goulmy, R, Schipper, J, Pool, E, Blokland, F, Falkenburg. 1996. Mismatches of Minor Histocompatibility Antigens Between HLA-Identical Donors and Recipients and the Development of Graft-Versus-Host Disease After Bone Marrow Transplantation. N Eng J Med 334(5): 281–85.Google Scholar
E, Goulmy. 2006. Minor histocompatibility antigens: from transplantation problems to therapy of cancer. Hum Immunol 67(6): 433–38.Google Scholar
G, Hill, J, Ferrara. 2000. The primacy of the gastrointestinal tract as a target organ of acute graft-versus-host disease: rationale for the use of cytokine shields in allogeneic bone marrow transplantation. Blood 95(9): 2754–59.Google Scholar
GR, Hill, JM, Crawford, KR, Cooke, YS, Brinson, L, Pan, JL, Ferrara. 1997. Total body irradiation and acute graft-versus-host disease: the role of gastrointestinal damage and inflammatory cytokines. Blood 90(8): 3204–13.Google Scholar
GR, Hill, JL, Ferrara. 2000. The primacy of the gastrointestinal tract as a target organ of acute graft-versus-host disease: rationale for the use of cytokine shields in allogeneic bone marrow transplantation. Blood 95(9): 2754–59.Google Scholar
GR, Hill, T, Teshima, VI, Rebel, et al. 2000. The p55 TNF-alpha receptor plays a critical role in T cell alloreactivity. J Immunol 164(2): 656–63.Google Scholar
E, Holler, G, Rogler, J, Brenmoehl, et al. 2006. Prognostic significance of NOD2/CARD15 variants in HLA-identical sibling hematopoietic stem cell transplantation: effect on long-term outcome is confirmed in 2 independent cohorts and may be modulated by the type of gastrointestinal decontamination. Blood 107(10): 4189–93.Google Scholar
KC, Hsu, T, Gooley, M, Malkki, et al. 2006. KIR Ligands and Prediction of Relapse after Unrelated Donor Hematopoietic Cell Transplantation for Hematologic Malignancy. Biol Blood Marrow Transplant 12(8): 828–36.Google Scholar
KC, Hsu, CA, Keever-Taylor, A, Wilton, et al. 2005. Improved outcome in HLA-identical sibling hematopoietic stem-cell transplantation for acute myelogenous leukemia predicted by KIR and HLA genotypes. Blood 105(12): 4878–84.Google Scholar
A, Iwasaki, R, Medzhitov. 2004. Toll-like receptor control of the adaptive immune responses. Nat Immunol 5(10): 987–95.Google Scholar
NA, Kernan, NH, Collins, L, Juliano, T, Cartagena, B, Dupont, RJ, O'Reilley. 1986. Clonable T lymphocytes in T cell-depleted bone marrow transplants correlate with development of graft-v-host disease. Blood 68: 770–3.Google Scholar
R, Korngold, J, Sprent. 1982. Features of T cells causing H-2-restricted lethal graft-vs.-host disease across minor histocompatibility barriers. J Exp Med 155(3): 872–83.Google Scholar
R, Korngold, J, Sprent. Purified T Cell subsets and lethal graft-versus-host disease In Mice. 1987. In: RP, Gale, R, Champlin, eds. Progress in Bone Marrow Transplantation. New York: Alan R. Liss, Inc., 213–218.Google Scholar
R, Korngold, J, Sprent. 1985. Surface markers of T cells causing lethal graft-vs-host disease to class I vs class II H-2 differences. J Immuno 135: 3004–3010.Google Scholar
AM, Krensky, A, Weiss, G, Crabtree, MM, Davis, P, Parham. 1990. T-lymphocyte-antigen interactions in transplant rejection. N Engl J Med 322(8): 510–17.Google Scholar
MJ, Laughlin, M, Eapen, P, Rubinstein, et al. 2004. Outcomes after transplantation of cord blood or bone marrow from unrelated donors in adults with leukemia. N Engl J Med 351(22): 2265–75.Google Scholar
SJ, Lee. 2005. New approaches for preventing and treating chronic graft-versus-host disease. Blood 105(11): 4200–06.Google Scholar
MT, Lin, B, Storer, PJ, Martin, et al. 2003. Relation of an interleukin-10 promoter polymorphism to graft-versus-host disease and survival after hematopoietic-cell transplantation. N Engl J Med 349(23): 2201–10.Google Scholar
R, Lowsky, T, Takahashi, YP, Liu, et al. 2005. Protective conditioning for acute graft-versus-host disease. N Engl J Med 353(13): 1321–31.Google Scholar
Y, Maeda, I, Tawara, T, Teshima, et al. 2007. Lymphopenia-induced proliferation of donor T cells reduces their capacity for causing acute graft-versus-host disease. Exp Hematol 35(2): 274–86.Google Scholar
S, Malarkannan, PP, Shih, PA, Eden, et al. 1998. The molecular and functional characterization of a dominant minor H antigen, H60. J Immunol 161(7): 3501–09.Google Scholar
S, Man, RD, Salter, VH, Engelhard. 1992. Role of endogenous peptide in human alloreactive cytotoxic T cell responses. Int Immunol 4(3): 367–75.Google Scholar
P, Matzinger. 2002. The danger model: a renewed sense of self. Science 296(5566): 301–5.Google Scholar
JS, Miller, S, Cooley, P, Parham, et al. 2007. Missing KIR-ligands is associated with less relapse and increased graft versus host disease (GVHD) following unrelated donor allogeneic HCT. Blood 109: 5058–61.Google Scholar
JS, Miller, Y, Soignier, A, Panoskaltsis-Mortari, et al. 2005. Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer. Blood 105(8): 3051–57.Google Scholar
CG, Mullighan, PG, Bardy. 2007. New directions in the genomics of allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 13(2): 127–44.Google Scholar
M, Murai, H, Yoneyama, T, Ezaki, et al. 2003. Peyer's patch is the essential site in initiating murine acute and lethal graft-versus-host reaction. Nat Immunol 4(2): 154–60.Google Scholar
M, Murata, EH, Warren, SR, Riddell. 2003. A human minor histocompatibility antigen resulting from differential expression due to a gene deletion. J Exp Med 197(10): 1279–89.Google Scholar
F, Paris, Z, Fuks, A, Kang, et al. 2001. Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice. Science 293(5528): 293–7.Google Scholar
EW, Petersdorf, GM, Longton, C, Anasetti, Em, Mickelson, SK, Mckinney. 1997. Association of HLA-C Disparity with Great Failure After Marrow Transplantation from Unrelated Donors. Blood 89(5): 1818–1823.Google Scholar
EW, Petersdorf, G, Longton, C, Anasetti, et al. 1995. Donor-recipient disparities for HLA-C genes is a risk factor for graft failure following marrow transplantation from unrelated donors. Blood 86, Suppl. 1: 291a.Google Scholar
EW, Petersdorf, M, Malkki. 2006. Genetics of risk factors for graft-versus-host disease. Semin Hematol 43(1): 11–23.Google Scholar
EW, Petersdorf. 2006. Immunogenomics of unrelated hematopoietic cell transplantation. Curr Opin Immunol 18: 559–64.Google Scholar
PF, Piguet, GE, Grau, B, Allet, PJ, Vassalli. 1987. Tumor necrosis factor/cachectin is an effector of skin and gut lesions of the acute phase of graft-versus-host disease. J Exp Med 166: 1280–89.Google Scholar
V, Ratanatharathorn, RA, Nash, D, Przepiorka, et al. 1998. Phase III study comparing methotrexate and tacrolimus (prograf, FK506) with methotrexate and cyclosporine for graft-versus-host disease prophylaxis after HLA-identical sibling bone marrow transplantation. Blood 92(7): 2303–14.Google Scholar
SR, Riddell, M, Bleakley, T, Nishida, C, Berger, EH, Warren. 2006. Adoptive transfer of allogeneic antigen-specific T cells. Biol Blood Marrow Transplant 12(1 Suppl 1): 9–12.Google Scholar
L, Ruggeri, M, Capanni, E, Urbani, et al. 2002. Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants. Science 295(5562): 2097–100.Google Scholar
K, Sato, N, Yamashita, M, Baba, T, Matsuyama. 2003. Regulatory dendritic cells protect mice from murine acute graft-versus-host disease and leukemia relapse. Immunity 18(3): 367–79.Google Scholar
C, Traversari, S, Marktel, Z, Magnani, et al. 2007. The potential immunogenicity of the TK suicide gene does not prevent full clinical benefit associated with the use of TK-transduced donor lymphocytes in HSCT for hematologic malignancies. Blood 109: 4708–15.Google Scholar
DW, Bekkum, MJ, Vries. 1967. Radiation chimaeras. London: Logos Press.Google Scholar
MR, Brink, SJ, Burakoff. 2002. Cytolytic pathways in haematopoietic stem-cell transplantation. Nat Rev Immunol 2(4): 273–81.Google Scholar
A, Velardi, L, Ruggeri, Moretta, A, Moretta, L. 2002. NK cells: a lesson from mismatched hematopoietic transplantation. Trends Immunol 23(9): 438–44.Google Scholar
E, Waldman, SX, Lu, VM, Hubbard, et al. 2006. Absence of beta7 integrin results in less graft-versus-host disease because of decreased homing of alloreactive T cells to intestine. Blood 107(4): 1703–11.Google Scholar
Wang, W, Man, S, Gulden, PH, Hunt, DF, Engelhard, VH. 1998. Class I-restricted alloreactive cytotoxic T lymphocytes recognize a complex array of specific MHC-associated peptides. J Immunol 160(3): 1091–97.Google ScholarPubMed
Weiden, PL, Flournoy, N, Thomas, ED, et al. 1979. Antileukemic effect of graft-versus-host disease in human recipients of allogeneic-marrow grafts. N Engl J Med 300(19): 1068–73.CrossRefGoogle ScholarPubMed
Weiden, PL, Sullivan, KM, Flournoy, N, Storb, R, Thomas, ED. 1981. Antileukemic effect of chronic graft-versus-host disease: Contribution to improved survival after allogeneic marrow transplantation. N Engl J Med 304: 1529–33.CrossRefGoogle ScholarPubMed
Welniak, , Blazar, BR, Murphy, WJ. 2007. Immunobiology of Allogeneic Hematopoietic Stem Cell Transplantation. Annu Rev Immunol 25: 139–70.CrossRefGoogle ScholarPubMed
Welniak, , Kuprash, DV, Tumanov, AV, et al. 2005. Peyer's patches are not required for acute graft-versus-host disease after myeloablative conditioning and murine allogeneic bone marrow transplantation. Blood 107: 410–12.CrossRefGoogle Scholar
Wysocki, CA, Panoskaltsis-Mortari, A, Blazar, BR, Serody, JS. 2005. Leukocyte migration and graft-versus-host disease. Blood 105(11): 4191–99.CrossRefGoogle ScholarPubMed
Xun, CQ, Thompson, JS, Jennings, CD, Brown, SA, Widmer, MB. 1994. Effect of total body irradiation, busulfan-cyclophosphamide, or cyclophosphamide conditioning on inflammatory cytokine release and development of acute and chronic graft-versus-host disease in H-2-incompatible transplanted SCID mice. Blood 83: 2360–67.Google ScholarPubMed
Yang, YG, Dey, BR, Sergio, JJ, Pearson, DA, Sykes, M. 1998. Donor-derived interferon gamma is required for inhibition of acute graft-versus-host disease by interleukin 12. J Clin Invest 102(12): 2126–35.CrossRefGoogle ScholarPubMed
Zeiser, R, Nguyen, VH, Beilhack, A, et al. 2006. Inhibition of CD4+CD25+ regulatory T-cell function by calcineurin-dependent interleukin-2 production. Blood 108(1): 390–99.CrossRefGoogle ScholarPubMed
Zeng, D, Lewis, D, Dejbakhsh-Jones, S, et al. 1999. Bone marrow NK1.1(-) and NK1.1(+) T cells reciprocally regulate acute graft versus host disease. J Exp Med 189(7): 1073–81.CrossRefGoogle ScholarPubMed
Zhang, Y, Joe, G, Hexner, E, Zhu, J, Emerson, SG. 2005. Host-reactive CD8+ memory stem cells in graft-versus-host disease. Nat Med 11(12): 1299–305.CrossRefGoogle ScholarPubMed

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×