Chapter four introduces the figure of the medical Creole. Renowned for being avaricious, extravagant, oversexed and slothful, white West Indian planters were vilified as cartoonish slobs in the anti-slavery press. While the British-Caribbean use of the term ‘Creole’ both during the Romantic period and in postcolonial studies today usually denotes a non-indigenous individual born in the Caribbean, the ‘Creole’ within colonial medical discourse referred to another type of body: an individual who had become ‘creolized’ through the medical process of ‘seasoning’ or acclimatization to the tropics. Recovering the medical etymology of the term ‘Creole’ supports a reconfigured postcolonial model of the Creole as hybrid through the lens of colonial medical discourse. Situating this unique category of colonial identity within the history of American, British and Caribbean scientific knowledge, this chapter also maps the contours of a specifically Creole medical empiricism which emerges from the white West Indian’s liminal social position between European and other, colonizer and colonized. The texts examined in this chapter—George Pinckard’s medical epistolary collection Notes on the West Indies (1806) and John Thelwall’s Haitian Revolution novel The Daughter of Adoption (1801)—also reveal the West Indian as not just a figure of fun, but of reform.