Book contents
- Frontmatter
- Contents
- Preface
- Contributors
- Part I Clinical Syndromes – General
- Part II Clinical Syndromes – Head and Neck
- Part III Clinical Syndromes – Eye
- Part IV Clinical Syndromes – Skin and Lymph Nodes
- Part V Clinical Syndromes – Respiratory Tract
- Part VI Clinical Syndromes – Heart and Blood Vessels
- Part VII Clinical Syndromes – Gastrointestinal Tract, Liver, and Abdomen
- Part VIII Clinical Syndromes – Genitourinary Tract
- Part IX Clinical Syndromes – Musculoskeletal System
- Part X Clinical Syndromes – Neurologic System
- Part XI The Susceptible Host
- Part XII HIV
- Part XIII Nosocomial Infection
- Part XIV Infections Related to Surgery and Trauma
- Part XV Prevention of Infection
- Part XVI Travel and Recreation
- Part XVII Bioterrorism
- Part XVIII Specific Organisms – Bacteria
- 121 Actinomycosis
- 122 Anaerobic Infections
- 123 Anthrax and Other Bacillus Species
- 124 Bartonellosis (Carrión's Disease)
- 125 Cat Scratch Disease and Other Bartonella Infections
- 126 Bordetella
- 127 Moraxella (Branhamella) Catarrhalis
- 128 Brucellosis
- 129 Campylobacter
- 130 Clostridia
- 131 Corynebacteria
- 132 Enterobacteriaceae
- 133 Enterococcus
- 134 Erysipelothrix
- 135 HACEK
- 136 Helicobacter Pylori
- 137 Gonococcus: Neisseria Gonorrhoeae
- 138 Haemophilus
- 139 Legionellosis
- 140 Leprosy
- 141 Meningococcus and Miscellaneous Neisseriae
- 142 Listeria
- 143 Nocardia
- 144 Pasteurella Multocida
- 145 Pneumococcus
- 146 Pseudomonas, Stenotrophomonas, and Burkholderia
- 147 Rat-Bite Fevers
- 148 Salmonella
- 149 Staphylococcus
- 150 Streptococcus Groups A, B, C, D, and G
- 151 Viridans Streptococci
- 152 Poststreptococcal Immunologic Complications
- 153 Shigella
- 154 Tularemia
- 155 Tuberculosis
- 156 Nontuberculous Mycobacteria
- 157 Vibrios
- 158 Yersinia
- 159 Miscellaneous Gram-Positive Organisms
- 160 Miscellaneous Gram-Negative Organisms
- Part XIX Specific Organisms – Spirochetes
- Part XX Specific Organisms – Mycoplasma and Chlamydia
- Part XXI Specific Organisms – Rickettsia, Ehrlichia, and Anaplasma
- Part XXII Specific Organisms – Fungi
- Part XXIII Specific Organisms – Viruses
- Part XXIV Specific Organisms – Parasites
- Part XXV Antimicrobial Therapy – General Considerations
- Index
136 - Helicobacter Pylori
from Part XVIII - Specific Organisms – Bacteria
Published online by Cambridge University Press: 05 March 2013
- Frontmatter
- Contents
- Preface
- Contributors
- Part I Clinical Syndromes – General
- Part II Clinical Syndromes – Head and Neck
- Part III Clinical Syndromes – Eye
- Part IV Clinical Syndromes – Skin and Lymph Nodes
- Part V Clinical Syndromes – Respiratory Tract
- Part VI Clinical Syndromes – Heart and Blood Vessels
- Part VII Clinical Syndromes – Gastrointestinal Tract, Liver, and Abdomen
- Part VIII Clinical Syndromes – Genitourinary Tract
- Part IX Clinical Syndromes – Musculoskeletal System
- Part X Clinical Syndromes – Neurologic System
- Part XI The Susceptible Host
- Part XII HIV
- Part XIII Nosocomial Infection
- Part XIV Infections Related to Surgery and Trauma
- Part XV Prevention of Infection
- Part XVI Travel and Recreation
- Part XVII Bioterrorism
- Part XVIII Specific Organisms – Bacteria
- 121 Actinomycosis
- 122 Anaerobic Infections
- 123 Anthrax and Other Bacillus Species
- 124 Bartonellosis (Carrión's Disease)
- 125 Cat Scratch Disease and Other Bartonella Infections
- 126 Bordetella
- 127 Moraxella (Branhamella) Catarrhalis
- 128 Brucellosis
- 129 Campylobacter
- 130 Clostridia
- 131 Corynebacteria
- 132 Enterobacteriaceae
- 133 Enterococcus
- 134 Erysipelothrix
- 135 HACEK
- 136 Helicobacter Pylori
- 137 Gonococcus: Neisseria Gonorrhoeae
- 138 Haemophilus
- 139 Legionellosis
- 140 Leprosy
- 141 Meningococcus and Miscellaneous Neisseriae
- 142 Listeria
- 143 Nocardia
- 144 Pasteurella Multocida
- 145 Pneumococcus
- 146 Pseudomonas, Stenotrophomonas, and Burkholderia
- 147 Rat-Bite Fevers
- 148 Salmonella
- 149 Staphylococcus
- 150 Streptococcus Groups A, B, C, D, and G
- 151 Viridans Streptococci
- 152 Poststreptococcal Immunologic Complications
- 153 Shigella
- 154 Tularemia
- 155 Tuberculosis
- 156 Nontuberculous Mycobacteria
- 157 Vibrios
- 158 Yersinia
- 159 Miscellaneous Gram-Positive Organisms
- 160 Miscellaneous Gram-Negative Organisms
- Part XIX Specific Organisms – Spirochetes
- Part XX Specific Organisms – Mycoplasma and Chlamydia
- Part XXI Specific Organisms – Rickettsia, Ehrlichia, and Anaplasma
- Part XXII Specific Organisms – Fungi
- Part XXIII Specific Organisms – Viruses
- Part XXIV Specific Organisms – Parasites
- Part XXV Antimicrobial Therapy – General Considerations
- Index
Summary
INTRODUCTION
Helicobacter pylori are gram-negative spiral shaped bacteria that infect more than 50% of humans globally. Helicobacter pylori infection is a serious chronic transmissible infectious disease that causes damage to gastric structure and function and is a major cause of morbidity and mortality worldwide. The prevalence of H. pylori is inversely related to the general health and well-being of a society. However, as with other chronic infectious diseases, the infection remains clinically latent in most with about 20% of infected individuals developing clinically recognizable diseases. The natural niche for the organism is the human stomach, where it causes destructive inflammation (eg, gastritis). Helicobacter pylori is now accepted as the major cause of gastric and duodenal ulcer disease, gastric cancer, and primary B-cell gastric lymphoma. It is also responsible for some cases of nonulcer dyspepsia.
DISCOVERY OF H. PYLORI
In the early 1980s, Robin Warren, a pathologist in Perth, Western Australia, who had observed small curved bacteria in gastric biopsy specimens, teamed up with a young trainee in internal medicine, Barry Marshall, to further investigate the role of these bacteria in human disease. By 1982, with a bit of luck, Marshall successfully isolated the organism from biopsy specimens. The organism was initially named Campylobacter pyloridis based on the insight from Warren that the organism looked like a Campylobacter. That organism is now known as H. pylori and is a microaerophilic, gram-negative, spiral rod approximately 0.6 × 3.5 μ with approximately 7 unipolar flagellae.
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- Clinical Infectious Disease , pp. 969 - 976Publisher: Cambridge University PressPrint publication year: 2008