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Chapter 9 - A Neuroimaging Network-Level Approach to Drug-Resistant Epilepsy

Published online by Cambridge University Press:  06 January 2023

By
Niels Alexander Foit ,
Fatemeh Fadaie ,
Andrea Bernasconi  and
Neda Bernasconi
Edited by
Rod C. Scott  and
J. Matthew Mahoney
Rod C. Scott
Affiliation:
University of Vermont
J. Matthew Mahoney
Affiliation:
University of Vermont
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Summary

Epilepsy affects approximately 1% of the population [1]. Although generally treatable, up to 30% of patients do not achieve seizure freedom from anticonvulsive medication alone. Due to its relationship with cognitive abilities [2], quality of life [3], and the associated risk of premature death [4], drug-refractory epilepsy should be treated promptly. Temporal lobe epilepsy (TLE) associated with mesiotemporal sclerosis [5] and extra-temporal lobe epilepsy related to focal cortical dysplasia (FCD) [6] constitute the most common refractory epilepsy syndromes. Surgical resection of these lesions remains the treatment of choice [7], with success rates approaching 80% [8]. By allowing the detection of epileptogenic lesions and offering system-level mechanisms of the disease process, MRI has shifted the field from electro-clinical correlations toward a multidisciplinary approach.

Type
Chapter
Information
A Complex Systems Approach to Epilepsy
Concept, Practice, and Therapy
 , pp. 127 - 134
Publisher: Cambridge University Press
Print publication year: 2023

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